Interleukin-18 induces transferrin expression in breast cancer cell line MCF-7

Sunyoung Park, Sun Young Yoon, Kyung Eun Kim, Ha Reum Lee, Dae Young Hur, Hyunkeun Song, Daejin Kim, Sa Ik Bang, Dae Ho Cho

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Interleukin-18 (IL-18) has recently been shown to have a pro-cancer effect in various cancers. Increased serum levels of both IL-18 and transferrin in cancer patients are correlated with its malignancy. However, the relationship between transferrin and IL-18 is not well understood. Here, we show that exogenous transferrin enhanced breast cancer cell proliferation and the proliferation rate was reduced when endogenous transferrin expression was inhibited by transferrin siRNA. The expression of endogenous transferrin was found to be regulated by IL-18. Furthermore, we found that the MAPK pathway is involved in IL-18-induced transferrin production. In conclusion, IL-18 is suggested as an inducer of endogenous transferrin expression in breast cancer cells.

Original languageEnglish
Pages (from-to)189-195
Number of pages7
JournalCancer letters
Volume286
Issue number2
DOIs
Publication statusPublished - 2009 Dec 28
Externally publishedYes

Fingerprint

Interleukin-18
Transferrin
Breast Neoplasms
Cell Line
Neoplasms
Small Interfering RNA
Cell Proliferation
Serum

Keywords

  • Breast cancer
  • Interleukin-18 (IL-18)
  • Proliferation
  • Transferrin

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Interleukin-18 induces transferrin expression in breast cancer cell line MCF-7. / Park, Sunyoung; Yoon, Sun Young; Kim, Kyung Eun; Lee, Ha Reum; Hur, Dae Young; Song, Hyunkeun; Kim, Daejin; Bang, Sa Ik; Cho, Dae Ho.

In: Cancer letters, Vol. 286, No. 2, 28.12.2009, p. 189-195.

Research output: Contribution to journalArticle

Park, S, Yoon, SY, Kim, KE, Lee, HR, Hur, DY, Song, H, Kim, D, Bang, SI & Cho, DH 2009, 'Interleukin-18 induces transferrin expression in breast cancer cell line MCF-7', Cancer letters, vol. 286, no. 2, pp. 189-195. https://doi.org/10.1016/j.canlet.2009.05.025
Park, Sunyoung ; Yoon, Sun Young ; Kim, Kyung Eun ; Lee, Ha Reum ; Hur, Dae Young ; Song, Hyunkeun ; Kim, Daejin ; Bang, Sa Ik ; Cho, Dae Ho. / Interleukin-18 induces transferrin expression in breast cancer cell line MCF-7. In: Cancer letters. 2009 ; Vol. 286, No. 2. pp. 189-195.
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