Interleukin-4 induces senescence in human renal carcinoma cell lines through STAT6 and p38 MAPK

Hag Dong Kim, Su Jin Yu, Hee Suk Kim, Yong Jin Kim, Jeong Min Choe, Yun Gyu Park, Joon Kim, Jeongwon Sohn

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background:IL-4 can directly inhibit growth of several tumor cell types, but the molecular mechanism is not known. Results:IL-4 induces senescence by increasing p21 WAF1/CIP1 expression through STAT6 and p38 MAPK. Conclusion:STAT6 and p38 MAPK play important roles in senescence induction by IL-4. Significance:This is the first report of cellular senescence induction by IL-4 and the responsible mechanism.

Original languageEnglish
Pages (from-to)28743-28754
Number of pages12
JournalJournal of Biological Chemistry
Volume288
Issue number40
DOIs
Publication statusPublished - 2013 Oct 4

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ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

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