Intermodality comparison between 3D perfusion CT and 18F-FDG PET/CT imaging for predicting early tumor response in patients with liver metastasis after chemotherapy: Preliminary results of a prospective study

Dong Hyun Kim, Se Hyung Kim, Seock Ah Im, Sae Won Han, Jin Mo Goo, Jürgen K. Willmann, Eun Seong Lee, Jae Seon Eo, Jin Chul Paeng, Joon Koo Han, Byung Ihn Choi

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objectives: To evaluate the feasibility of 3D perfusion CT for predicting early treatment response in patients with liver metastasis from colorectal cancer. Methods: Seventeen patients with colon cancer and liver metastasis were prospectively enroled to undergo perfusion CT and 18F-FDG-PET/CT before and after one-cycle of chemotherapy. Two radiologists and three nuclear medicine physicians measured various perfusion CT and PET/CT parameters, respectively from the largest hepatic metastasis. Baseline values and reduction rates of the parameters were compared between responders and nonresponders. Spearman correlation test was used to correlate perfusion CT and PET/CT parameters, using RECIST criteria as reference standard. Results: Nine patients responded to treatment, eight patients were nonresponders. Baseline SUVmean30 on PET/CT, reduction rates of 30% metabolic volume and 30% lesion glycolysis (LG30) on PET/CT and blood flow (BF) and flow extraction product (FEP) on perfusion CT after chemotherapy were significantly different between responders and nonresponders (P = 0.008-0.046). Reduction rates of BF (correlation coefficient = 0.630) and FEP (correlation coefficient = 0.578) significantly correlated with that of LG30 on PET/CT (P < 0.05). Conclusion: CT perfusion parameters including BF and FEP may be used as early predictors of tumor response in patients with liver metastasis from colorectal cancer.

Original languageEnglish
Pages (from-to)3542-3550
Number of pages9
JournalEuropean Journal of Radiology
Volume81
Issue number11
DOIs
Publication statusPublished - 2012 Nov 1
Externally publishedYes

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Fluorodeoxyglucose F18
Perfusion
Prospective Studies
Neoplasm Metastasis
Drug Therapy
Liver
Neoplasms
Colorectal Neoplasms
Nuclear Medicine
Glycolysis
Liver Neoplasms
Colonic Neoplasms
Physicians
Therapeutics

Keywords

  • Angiogenesis
  • Colon cancer
  • CT
  • CT perfusion
  • Liver metastasis
  • PET

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Intermodality comparison between 3D perfusion CT and 18F-FDG PET/CT imaging for predicting early tumor response in patients with liver metastasis after chemotherapy : Preliminary results of a prospective study. / Kim, Dong Hyun; Kim, Se Hyung; Im, Seock Ah; Han, Sae Won; Goo, Jin Mo; Willmann, Jürgen K.; Lee, Eun Seong; Eo, Jae Seon; Paeng, Jin Chul; Han, Joon Koo; Choi, Byung Ihn.

In: European Journal of Radiology, Vol. 81, No. 11, 01.11.2012, p. 3542-3550.

Research output: Contribution to journalArticle

Kim, Dong Hyun ; Kim, Se Hyung ; Im, Seock Ah ; Han, Sae Won ; Goo, Jin Mo ; Willmann, Jürgen K. ; Lee, Eun Seong ; Eo, Jae Seon ; Paeng, Jin Chul ; Han, Joon Koo ; Choi, Byung Ihn. / Intermodality comparison between 3D perfusion CT and 18F-FDG PET/CT imaging for predicting early tumor response in patients with liver metastasis after chemotherapy : Preliminary results of a prospective study. In: European Journal of Radiology. 2012 ; Vol. 81, No. 11. pp. 3542-3550.
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abstract = "Objectives: To evaluate the feasibility of 3D perfusion CT for predicting early treatment response in patients with liver metastasis from colorectal cancer. Methods: Seventeen patients with colon cancer and liver metastasis were prospectively enroled to undergo perfusion CT and 18F-FDG-PET/CT before and after one-cycle of chemotherapy. Two radiologists and three nuclear medicine physicians measured various perfusion CT and PET/CT parameters, respectively from the largest hepatic metastasis. Baseline values and reduction rates of the parameters were compared between responders and nonresponders. Spearman correlation test was used to correlate perfusion CT and PET/CT parameters, using RECIST criteria as reference standard. Results: Nine patients responded to treatment, eight patients were nonresponders. Baseline SUVmean30 on PET/CT, reduction rates of 30{\%} metabolic volume and 30{\%} lesion glycolysis (LG30) on PET/CT and blood flow (BF) and flow extraction product (FEP) on perfusion CT after chemotherapy were significantly different between responders and nonresponders (P = 0.008-0.046). Reduction rates of BF (correlation coefficient = 0.630) and FEP (correlation coefficient = 0.578) significantly correlated with that of LG30 on PET/CT (P < 0.05). Conclusion: CT perfusion parameters including BF and FEP may be used as early predictors of tumor response in patients with liver metastasis from colorectal cancer.",
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AU - Im, Seock Ah

AU - Han, Sae Won

AU - Goo, Jin Mo

AU - Willmann, Jürgen K.

AU - Lee, Eun Seong

AU - Eo, Jae Seon

AU - Paeng, Jin Chul

AU - Han, Joon Koo

AU - Choi, Byung Ihn

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N2 - Objectives: To evaluate the feasibility of 3D perfusion CT for predicting early treatment response in patients with liver metastasis from colorectal cancer. Methods: Seventeen patients with colon cancer and liver metastasis were prospectively enroled to undergo perfusion CT and 18F-FDG-PET/CT before and after one-cycle of chemotherapy. Two radiologists and three nuclear medicine physicians measured various perfusion CT and PET/CT parameters, respectively from the largest hepatic metastasis. Baseline values and reduction rates of the parameters were compared between responders and nonresponders. Spearman correlation test was used to correlate perfusion CT and PET/CT parameters, using RECIST criteria as reference standard. Results: Nine patients responded to treatment, eight patients were nonresponders. Baseline SUVmean30 on PET/CT, reduction rates of 30% metabolic volume and 30% lesion glycolysis (LG30) on PET/CT and blood flow (BF) and flow extraction product (FEP) on perfusion CT after chemotherapy were significantly different between responders and nonresponders (P = 0.008-0.046). Reduction rates of BF (correlation coefficient = 0.630) and FEP (correlation coefficient = 0.578) significantly correlated with that of LG30 on PET/CT (P < 0.05). Conclusion: CT perfusion parameters including BF and FEP may be used as early predictors of tumor response in patients with liver metastasis from colorectal cancer.

AB - Objectives: To evaluate the feasibility of 3D perfusion CT for predicting early treatment response in patients with liver metastasis from colorectal cancer. Methods: Seventeen patients with colon cancer and liver metastasis were prospectively enroled to undergo perfusion CT and 18F-FDG-PET/CT before and after one-cycle of chemotherapy. Two radiologists and three nuclear medicine physicians measured various perfusion CT and PET/CT parameters, respectively from the largest hepatic metastasis. Baseline values and reduction rates of the parameters were compared between responders and nonresponders. Spearman correlation test was used to correlate perfusion CT and PET/CT parameters, using RECIST criteria as reference standard. Results: Nine patients responded to treatment, eight patients were nonresponders. Baseline SUVmean30 on PET/CT, reduction rates of 30% metabolic volume and 30% lesion glycolysis (LG30) on PET/CT and blood flow (BF) and flow extraction product (FEP) on perfusion CT after chemotherapy were significantly different between responders and nonresponders (P = 0.008-0.046). Reduction rates of BF (correlation coefficient = 0.630) and FEP (correlation coefficient = 0.578) significantly correlated with that of LG30 on PET/CT (P < 0.05). Conclusion: CT perfusion parameters including BF and FEP may be used as early predictors of tumor response in patients with liver metastasis from colorectal cancer.

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