Internal chelation-guided regio- and stereoselective Pauson-Khand-type reaction by chiral Rhodium(I) catalysis

Dong Eun Kim, Sang Hee Park, Yun Hee Choi, Sueg Geun Lee, Dohyun Moon, Jungju Seo, Nakcheol Jeong

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Touch, Pauson, engage: To explain the unique superior reactivity and stereoselectivity of O-tethered enynes in asymmetric Pauson-Khand type reaction (APKR) than their congeners, the internal-chelation to metal of oxygen atom of the substrate in the transition state was proposed. This proposition was well supported by APKR with several different substrates.

Original languageEnglish
Pages (from-to)2009-2014
Number of pages6
JournalChemistry - An Asian Journal
Volume6
Issue number8
DOIs
Publication statusPublished - 2011 Aug 1

Keywords

  • Pauson-Khand reaction
  • chelation effects
  • enantioselectivity
  • kinetic resolution
  • rhodium

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry

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