Internal interaction changes within the mutation of SLC26A4 STAS domain

Jae In Kim, Hyunjoon Chang, Myeongsang Lee, Sung Soo Na

Research output: Contribution to journalArticle

Abstract

Pendrin (SLC26A4) is a protein associated with the auditory system. Pendred syndrome (PDS) and DFNB4 are typical auditory disorders caused by mutations in the SLC26A4 STAS domain. We generated an SLC26A4 STAS domain model and six mutated STAS domain models related to PDS, DFNB4, and PDS/DFNB4 by homology modeling. Molecular dynamics simulation was performed to find the equilibration conformation and fluctuation information. Using fluctuation information, we calculated betweenness centrality and edge betweenness to reveal communication between secondary structures of STAS domain. The edge betweenness results showed that mutated models generate communication signals that are less clear than WT models.

Original languageEnglish
Pages (from-to)226-233
Number of pages8
JournalChemical Physics Letters
Volume710
DOIs
Publication statusPublished - 2018 Oct 16

Keywords

  • DFNB4
  • Molecular dynamics
  • Network analysis
  • PDS
  • Pendrin (SLC26A4)

ASJC Scopus subject areas

  • Physics and Astronomy(all)
  • Physical and Theoretical Chemistry

Fingerprint Dive into the research topics of 'Internal interaction changes within the mutation of SLC26A4 STAS domain'. Together they form a unique fingerprint.

  • Cite this