Interobservervariabilität in Abgrenzung zum makroskopischen Tumorvolumen für hepatozelluläre Karzinome: Ergebnisse der Korean Radiation Oncology Group 1207 Study

Translated title of the contribution: Interobserver variability in gross tumor volume delineation for hepatocellular carcinoma: Results of Korean Radiation Oncology Group 1207 study

Young Suk Kim, Jun Won Kim, Won Sup Yoon, Min Kyu Kang, Ik Jae Lee, Tae Hyun Kim, Jin Hee Kim, Hyung Sik Lee, Hee Chul Park, Hong Seok Jang, Chul Seung Kay, Sang Min Yoon, Mi Sook Kim, Jinsil Seong

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Purpose: There has been increasing use of external beam radiotherapy for localized treatment of hepatocellular carcinoma (HCC) with both palliative and curative intent. Quality control of target delineation in primary HCC is essential to deliver adequate doses of radiation to the primary tumor while preserving adjacent healthy organs. We analyzed interobserver variability in gross tumor volume (GTV) delineation for HCC. Patients and methods: Twelve radiation oncologists specializing in liver malignancy participated in a multi-institutional contouring dummy-run study of nine HCC cases and independently delineated GTV on the same set of provided computed tomography images. Quantitative analysis was performed using an expectation maximization algorithm for simultaneous truth and performance level estimation (STAPLE) with kappa statistics calculating agreement between physicians. To quantify the interobserver variability of GTV delineations, the ratio of the actual delineated volume to the estimated consensus volume (STAPLE), the ratio of the common and encompassing volumes, and the coefficient of variation were calculated. Results: The median kappa agreement level was 0.71 (range 0.28–0.86). The ratio of the actual delineated volume to the estimated consensus volume ranged from 0.19 to 1.93 (median 0.94) for all cases. The ratio of the common and encompassing volumes ranged from 0.001 to 0.56 (median 0.25). The coefficient of variation for GTV delineation ranged from 8 to 57 % (median 26 %). Conclusion: The interobserver variability in target delineation of HCC GTV in this study is noteworthy. Multi-institution studies involving radiotherapy for HCC require appropriate quality assurance programs for target delineation.

Translated title of the contributionInterobserver variability in gross tumor volume delineation for hepatocellular carcinoma: Results of Korean Radiation Oncology Group 1207 study
Original languageGerman
Pages (from-to)714-721
Number of pages8
JournalStrahlentherapie und Onkologie
Volume192
Issue number10
DOIs
Publication statusPublished - 2016 Oct 1

Keywords

  • Chemoembolization
  • Organs at risk
  • Quality assurance
  • Radiofrequency ablation
  • Radiotherapy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Oncology

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    Kim, Y. S., Kim, J. W., Yoon, W. S., Kang, M. K., Lee, I. J., Kim, T. H., Kim, J. H., Lee, H. S., Park, H. C., Jang, H. S., Kay, C. S., Yoon, S. M., Kim, M. S., & Seong, J. (2016). Interobservervariabilität in Abgrenzung zum makroskopischen Tumorvolumen für hepatozelluläre Karzinome: Ergebnisse der Korean Radiation Oncology Group 1207 Study. Strahlentherapie und Onkologie, 192(10), 714-721. https://doi.org/10.1007/s00066-016-1028-2