Interrelationship between secondary metabolites and antioxidant capacities of Centella asiatica using bivariate and multivariate correlation analyses

Hyun Young Shin, Hoon Kim, Soontag Jung, Eun Jin Jeong, Kyung Haeng Lee, Yun Jung Bae, Hyung Joo Suh, Keum Il Jang, Kwang Won Yu

Research output: Contribution to journalArticlepeer-review

Abstract

Centella asiatica L. Urban (CA) is a valuable medicinal herb that contains various bioactive secondary metabolites. In the present study, the harvested CA was divided into whole plant and leaf parts, and were heated-air-dried or freeze-dried. The dried CA was extracted under various extraction conditions to obtain 16 extracts, and their antioxidant activities were examined. Twelve types of secondary metabolites (five polyphenolic acids, four triterpenoids, and three flavonoids) were quantified in each extract. Finally, the intercorrelations between secondary metabolites and antioxidant activities were analyzed through statistical analyses, such as Pearson correlation coefficient, scatter plotting, and principal component analysis. The antioxidant capacities of CA might be primarily influenced by major triterpenoids such as madecassoside and asiaticoside, which showed high content in the ethanol extracts of freeze-dried leaf parts. The present study provides a valuable groundwork for the development of optimal extraction processes for C. asiatica L. as an antioxidant material.

Original languageEnglish
Article number82
JournalApplied Biological Chemistry
Volume64
Issue number1
DOIs
Publication statusPublished - 2021 Dec

Keywords

  • Antioxidant activity
  • Centella asiatica
  • Component-activity relationship
  • Drying method
  • Principal component analysis
  • Triterpenoid

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Organic Chemistry

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