Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo

Hongki Yoo; Jin Won Kim; Milen Shishkov; Eman Namati; Theodore Morse; Roman Shubochkin; Jason R. McCarthy; Vasilis Ntziachristos; Brett E. Bouma; Farouc A. Jaffer; Guillermo J. Tearney

doi:10.1038/nm.2555

Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo

Hongki Yoo, Jin Won Kim, Milen Shishkov, Eman Namati, Theodore Morse, Roman Shubochkin, Jason R. McCarthy, Vasilis Ntziachristos, Brett E. Bouma, Farouc A. Jaffer, Guillermo J. Tearney

Research output: Contribution to journal › Article › peer-review

248 Citations (Scopus)

Abstract

Advancing understanding of human coronary artery disease requires new methods that can be used in patients for studying atherosclerotic plaque microstructure in relation to the molecular mechanisms that underlie its initiation, progression and clinical complications, including myocardial infarction and sudden cardiac death. Here we report a dual-modality intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo using a combination of optical frequency domain imaging (OFDI) and near-infrared fluorescence (NIRF) imaging. By providing simultaneous molecular information in the context of the surrounding tissue microstructure, this new catheter could provide new opportunities for investigating coronary atherosclerosis and stent healing and for identifying high-risk biological and structural coronary arterial plaques in vivo.

Original language	English
Pages (from-to)	1680-1684
Number of pages	5
Journal	Nature Medicine
Volume	17
Issue number	12
DOIs	https://doi.org/10.1038/nm.2555
Publication status	Published - 2011 Dec

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo",

abstract = "Advancing understanding of human coronary artery disease requires new methods that can be used in patients for studying atherosclerotic plaque microstructure in relation to the molecular mechanisms that underlie its initiation, progression and clinical complications, including myocardial infarction and sudden cardiac death. Here we report a dual-modality intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo using a combination of optical frequency domain imaging (OFDI) and near-infrared fluorescence (NIRF) imaging. By providing simultaneous molecular information in the context of the surrounding tissue microstructure, this new catheter could provide new opportunities for investigating coronary atherosclerosis and stent healing and for identifying high-risk biological and structural coronary arterial plaques in vivo.",

author = "Hongki Yoo and Kim, {Jin Won} and Milen Shishkov and Eman Namati and Theodore Morse and Roman Shubochkin and McCarthy, {Jason R.} and Vasilis Ntziachristos and Bouma, {Brett E.} and Jaffer, {Farouc A.} and Tearney, {Guillermo J.}",

note = "Funding Information: We thank J. Gardecki for preparation of the cadaver coronary artery and CVPath for pathology of the stented artery. We also thank A. Rosenthal and G. Mallas for their technical support and A. Mauskapf for preparing and assisting in animal procedures. We thank Y. Iwamoto, Y. Yagi and E. Salomatina for assistance in histopathology. This research was supported in part by the US National Institutes of Health (R01HL076398 and R01HL093717 to G.J.T. and R01HL108229-01A1 to F.A.J.), the Center for Integration of Medicine and Innovative Technology (DAMD17-02-2-0006 to G.J.T. and F.A.J.), an American Heart Association Scientist Development grant (#0830352N to F.A.J.), a Howard Hughes Medical Institute Early Career Award (F.A.J.) and the CardioVascular Research Foundation (CVRF, J.W.K.).",

year = "2011",

month = dec,

doi = "10.1038/nm.2555",

language = "English",

volume = "17",

pages = "1680--1684",

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T1 - Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo

AU - Yoo, Hongki

AU - Kim, Jin Won

AU - Shishkov, Milen

AU - Namati, Eman

AU - Morse, Theodore

AU - Shubochkin, Roman

AU - McCarthy, Jason R.

AU - Ntziachristos, Vasilis

AU - Bouma, Brett E.

AU - Jaffer, Farouc A.

AU - Tearney, Guillermo J.

N1 - Funding Information: We thank J. Gardecki for preparation of the cadaver coronary artery and CVPath for pathology of the stented artery. We also thank A. Rosenthal and G. Mallas for their technical support and A. Mauskapf for preparing and assisting in animal procedures. We thank Y. Iwamoto, Y. Yagi and E. Salomatina for assistance in histopathology. This research was supported in part by the US National Institutes of Health (R01HL076398 and R01HL093717 to G.J.T. and R01HL108229-01A1 to F.A.J.), the Center for Integration of Medicine and Innovative Technology (DAMD17-02-2-0006 to G.J.T. and F.A.J.), an American Heart Association Scientist Development grant (#0830352N to F.A.J.), a Howard Hughes Medical Institute Early Career Award (F.A.J.) and the CardioVascular Research Foundation (CVRF, J.W.K.).

PY - 2011/12

Y1 - 2011/12

N2 - Advancing understanding of human coronary artery disease requires new methods that can be used in patients for studying atherosclerotic plaque microstructure in relation to the molecular mechanisms that underlie its initiation, progression and clinical complications, including myocardial infarction and sudden cardiac death. Here we report a dual-modality intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo using a combination of optical frequency domain imaging (OFDI) and near-infrared fluorescence (NIRF) imaging. By providing simultaneous molecular information in the context of the surrounding tissue microstructure, this new catheter could provide new opportunities for investigating coronary atherosclerosis and stent healing and for identifying high-risk biological and structural coronary arterial plaques in vivo.

AB - Advancing understanding of human coronary artery disease requires new methods that can be used in patients for studying atherosclerotic plaque microstructure in relation to the molecular mechanisms that underlie its initiation, progression and clinical complications, including myocardial infarction and sudden cardiac death. Here we report a dual-modality intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo using a combination of optical frequency domain imaging (OFDI) and near-infrared fluorescence (NIRF) imaging. By providing simultaneous molecular information in the context of the surrounding tissue microstructure, this new catheter could provide new opportunities for investigating coronary atherosclerosis and stent healing and for identifying high-risk biological and structural coronary arterial plaques in vivo.

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Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo

Abstract

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