Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo

Hongki Yoo, Jin Won Kim, Milen Shishkov, Eman Namati, Theodore Morse, Roman Shubochkin, Jason R. McCarthy, Vasilis Ntziachristos, Brett E. Bouma, Farouc A. Jaffer, Guillermo J. Tearney

    Research output: Contribution to journalArticlepeer-review

    223 Citations (Scopus)

    Abstract

    Advancing understanding of human coronary artery disease requires new methods that can be used in patients for studying atherosclerotic plaque microstructure in relation to the molecular mechanisms that underlie its initiation, progression and clinical complications, including myocardial infarction and sudden cardiac death. Here we report a dual-modality intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo using a combination of optical frequency domain imaging (OFDI) and near-infrared fluorescence (NIRF) imaging. By providing simultaneous molecular information in the context of the surrounding tissue microstructure, this new catheter could provide new opportunities for investigating coronary atherosclerosis and stent healing and for identifying high-risk biological and structural coronary arterial plaques in vivo.

    Original languageEnglish
    Pages (from-to)1680-1684
    Number of pages5
    JournalNature Medicine
    Volume17
    Issue number12
    DOIs
    Publication statusPublished - 2011 Dec

    ASJC Scopus subject areas

    • Biochemistry, Genetics and Molecular Biology(all)

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