Intra-mitochondrial self-assembly to overcome the intracellular enzymatic degradation ofl-peptides

M. T. Jeena, Seokyoung Lee, Ayan Kumar Barui, Seongeon Jin, Yuri Cho, Suk Won Hwang, Sehoon Kim, Ja Hyoung Ryu

Research output: Contribution to journalArticle

Abstract

The design of peptide-based therapeutics is generally based on the replacement ofl-amino acids withd-isomers to obtain improved therapeutic efficiency. However,d-isomers are expensive and frequently induce undesirable immune responses. In the present work, we demonstrate that an intra-mitochondrially self-assembling amphiphilic peptide exhibits analogous activity in bothd- andl-isomeric forms. This outcome is in contrast to the general observation considering higher therapeutic efficiencies ofd-isomers compared withl-analogues. This suggests thatl-peptides overcome proteolytic degradation during intra-mitochondrial self-assembly bothin vitroandin vivo.

Original languageEnglish
Pages (from-to)6265-6268
Number of pages4
JournalChemical Communications
Volume56
Issue number46
DOIs
Publication statusPublished - 2020 Jun 11

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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