Intraarticular pretreatment with ketamine and memantine could prevent arthritic pain

Relevance to the decrease of spinal c-Fos expression in rats

Guo Hua Zhang, Sun Seek Min, Kyu Sang Lee, Seung Keun Back, Seong Jun Yoon, Young Wook Yoon, Yang In Kim, Heung Sik Na, Seung Kil Hong, Hee Chul Han

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

To determine whether intraarticular pretreatment with N-methyl-D-aspartic (NMDA) receptor antagonist ketamine or memantine currently used in humans has prophylactic analgesia in arthritic pain, we examined the effects of their intraarticular injection before carrageenan injection into the knee joint on pain-related behavior and spinal c-Fos expression in rats. Injection of ketamine (0.2 mg and 1 mg) or memantine (0.1 mg, 0.2 mg, and 1 mg) into the knee joint, but not the abdominal cavity, immediately before carrageenan injection (2%, 40 μL) significantly prevented pain-related behavior. The intraarticular injection of ketamine (1 mg) or memantine (0.2 mg) also suppressed c-Fos expression in the laminae I-II and laminae V-VI at the L3-4 spinal level. Subsequent statistical analyses revealed that the degree of the spinal c-Fos expression was correlated with the extent of the pain-related behavior. These results suggest that peripheral administration of NMDA receptor antagonists has prophylactic analgesic effects in arthritic pain, which might be associated with the decrease of central nociceptive signaling. Because ketamine and memantine are currently used in humans and considered clinically safe, they may have therapeutic value in the treatment of joint pain.

Original languageEnglish
Pages (from-to)152-158
Number of pages7
JournalAnesthesia and Analgesia
Volume99
Issue number1
Publication statusPublished - 2004 Jul 1

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Memantine
Ketamine
Arthritis
Rats
Pain
Intra-Articular Injections
Carrageenan
Arthralgia
Knee Joint
Injections
Abdominal Cavity
Analgesia
Analgesics
Therapeutics

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Intraarticular pretreatment with ketamine and memantine could prevent arthritic pain : Relevance to the decrease of spinal c-Fos expression in rats. / Zhang, Guo Hua; Min, Sun Seek; Lee, Kyu Sang; Back, Seung Keun; Yoon, Seong Jun; Yoon, Young Wook; Kim, Yang In; Na, Heung Sik; Hong, Seung Kil; Han, Hee Chul.

In: Anesthesia and Analgesia, Vol. 99, No. 1, 01.07.2004, p. 152-158.

Research output: Contribution to journalArticle

Zhang, Guo Hua ; Min, Sun Seek ; Lee, Kyu Sang ; Back, Seung Keun ; Yoon, Seong Jun ; Yoon, Young Wook ; Kim, Yang In ; Na, Heung Sik ; Hong, Seung Kil ; Han, Hee Chul. / Intraarticular pretreatment with ketamine and memantine could prevent arthritic pain : Relevance to the decrease of spinal c-Fos expression in rats. In: Anesthesia and Analgesia. 2004 ; Vol. 99, No. 1. pp. 152-158.
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