Intracerebroventricular infusion of the galanin antagonist M40 attenuates heterosexual partner preference in ferrets

Joong Jean Park, Michael J. Baum

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Gonadectomized, estradiol-treated male and female ferrets (Mustela furo) received intracerebroventricular (icv) infusions of 4 doses of the galanin receptor antagonist M40 or galanin and were allowed to approach breeding male or female ferrets that were placed behind wire mesh barriers in the goal boxes of a T maze. After icv infusion of saline, subjects strongly preferred to approach stimulus ferrets of the opposite sex. Male and female subjects approached these preferred stimulus animals on significantly fewer trials after icy infusion of the 2 highest doses of M40, whereas this drug failed to affect males' coital behavior in separate tests with an estrous female. Endogenous galanin may facilitate neural reward mechanisms that control heterosexual partner preference in both sexes.

Original languageEnglish
Pages (from-to)391-400
Number of pages10
JournalBehavioral Neuroscience
Volume113
Issue number2
DOIs
Publication statusPublished - 1999

ASJC Scopus subject areas

  • Behavioral Neuroscience

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