Abstract
Gonadectomized, estradiol-treated male and female ferrets (Mustela furo) received intracerebroventricular (icv) infusions of 4 doses of the galanin receptor antagonist M40 or galanin and were allowed to approach breeding male or female ferrets that were placed behind wire mesh barriers in the goal boxes of a T maze. After icv infusion of saline, subjects strongly preferred to approach stimulus ferrets of the opposite sex. Male and female subjects approached these preferred stimulus animals on significantly fewer trials after icy infusion of the 2 highest doses of M40, whereas this drug failed to affect males' coital behavior in separate tests with an estrous female. Endogenous galanin may facilitate neural reward mechanisms that control heterosexual partner preference in both sexes.
| Original language | English |
|---|---|
| Pages (from-to) | 391-400 |
| Number of pages | 10 |
| Journal | Behavioral Neuroscience |
| Volume | 113 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1999 May 26 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Behavioral Neuroscience
- Clinical Psychology
Cite this
Intracerebroventricular infusion of the galanin antagonist M40 attenuates heterosexual partner preference in ferrets. / Park, Joong Jean; Baum, Michael J.
In: Behavioral Neuroscience, Vol. 113, No. 2, 26.05.1999, p. 391-400.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Intracerebroventricular infusion of the galanin antagonist M40 attenuates heterosexual partner preference in ferrets
AU - Park, Joong Jean
AU - Baum, Michael J.
PY - 1999/5/26
Y1 - 1999/5/26
N2 - Gonadectomized, estradiol-treated male and female ferrets (Mustela furo) received intracerebroventricular (icv) infusions of 4 doses of the galanin receptor antagonist M40 or galanin and were allowed to approach breeding male or female ferrets that were placed behind wire mesh barriers in the goal boxes of a T maze. After icv infusion of saline, subjects strongly preferred to approach stimulus ferrets of the opposite sex. Male and female subjects approached these preferred stimulus animals on significantly fewer trials after icy infusion of the 2 highest doses of M40, whereas this drug failed to affect males' coital behavior in separate tests with an estrous female. Endogenous galanin may facilitate neural reward mechanisms that control heterosexual partner preference in both sexes.
AB - Gonadectomized, estradiol-treated male and female ferrets (Mustela furo) received intracerebroventricular (icv) infusions of 4 doses of the galanin receptor antagonist M40 or galanin and were allowed to approach breeding male or female ferrets that were placed behind wire mesh barriers in the goal boxes of a T maze. After icv infusion of saline, subjects strongly preferred to approach stimulus ferrets of the opposite sex. Male and female subjects approached these preferred stimulus animals on significantly fewer trials after icy infusion of the 2 highest doses of M40, whereas this drug failed to affect males' coital behavior in separate tests with an estrous female. Endogenous galanin may facilitate neural reward mechanisms that control heterosexual partner preference in both sexes.
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U2 - 10.1037/0735-7044.113.2.391
DO - 10.1037/0735-7044.113.2.391
M3 - Article
C2 - 10357463
AN - SCOPUS:0032895747
VL - 113
SP - 391
EP - 400
JO - Behavioral Neuroscience
JF - Behavioral Neuroscience
SN - 0735-7044
IS - 2
ER -