Intracerebroventricular infusion of the galanin antagonist M40 attenuates heterosexual partner preference in ferrets

Joong Jean Park, Michael J. Baum

    Research output: Contribution to journalArticlepeer-review

    16 Citations (Scopus)

    Abstract

    Gonadectomized, estradiol-treated male and female ferrets (Mustela furo) received intracerebroventricular (icv) infusions of 4 doses of the galanin receptor antagonist M40 or galanin and were allowed to approach breeding male or female ferrets that were placed behind wire mesh barriers in the goal boxes of a T maze. After icv infusion of saline, subjects strongly preferred to approach stimulus ferrets of the opposite sex. Male and female subjects approached these preferred stimulus animals on significantly fewer trials after icy infusion of the 2 highest doses of M40, whereas this drug failed to affect males' coital behavior in separate tests with an estrous female. Endogenous galanin may facilitate neural reward mechanisms that control heterosexual partner preference in both sexes.

    Original languageEnglish
    Pages (from-to)391-400
    Number of pages10
    JournalBehavioral Neuroscience
    Volume113
    Issue number2
    DOIs
    Publication statusPublished - 1999

    ASJC Scopus subject areas

    • Behavioral Neuroscience

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