Intracisternal and intraperitoneal administration of morphine attenuates mechanical allodynia following compression of the trigeminal ganglion in rats

Min K. Lee, Hea J. Shin, Gwi Y. Yang, Young W. Yoon, Seong K. Han, Yong C. Bae, Dong K. Ahn

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Aims: To investigate the effects of morphine on mechanical allodynia following compression of the trigeminal ganglion in the rat. Methods: Experiments were carried out on male Sprague-Dawley rats weighing between 250 and 260 g. For compression, a 4% agar solution (8 μL) was injected into the trigeminal ganglion. In the control group, rats were sham operated without agar injections. The authors evaluated the effects of intraperitoneal or intracisternal administration of morphine on mechanical allodynia evoked by airpuffstimulation of the vibrissa pad area 14 days following compression of the trigeminal ganglion. Results: Mechanical allodynia was established within 3 days and lasted beyond postoperative day 24. Intraperitoneal administration of morphine (2 or 5 mg/kg) significantly blocked mechanical allodynia ipsilateral to the compression of the trigeminal ganglion. Intraperitoneal administration of morphine also inhibited mechanical allodynia on the contralateral side. Moreover, intracisternal administration of morphine (5 μg) strongly suppressed both ipsilateral and contralateral mechanical allodynia. The antiallodynic effects of morphine were blocked by pretreatment with naloxone, an opioid receptor antagonist. Conclusion: These results suggest that the application of a high dose of morphine may be of great benefit in treating trigeminal neuralgia-like nociception.

Original languageEnglish
Pages (from-to)113-121
Number of pages9
JournalJournal of Oral and Facial Pain and Headache
Volume24
Issue number1
Publication statusPublished - 2010

Keywords

  • Allodynia
  • Animal model
  • Morphine
  • Trigeminal ganglion
  • Trigeminal neuralgia

ASJC Scopus subject areas

  • Dentistry (miscellaneous)
  • Clinical Neurology
  • Anesthesiology and Pain Medicine

Fingerprint Dive into the research topics of 'Intracisternal and intraperitoneal administration of morphine attenuates mechanical allodynia following compression of the trigeminal ganglion in rats'. Together they form a unique fingerprint.

Cite this