Intracisternal or intrathecal glycine, taurine, or muscimol inhibit bicuculline-induced allodynia and thermal hyperalgesia in mice

Il Ok Lee, Eui Sung Lim

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Aim: To investigate the effects of GABA and glycine on analgesia in the central nervous system.Methods:Glycine, taurine, or muscimol was injected with bicuculline into the cistern magna or the lumbar subarachnoidal space in ICR mice. The effects on bicuculline-induced allodynia in a touch-evoked agitation test and on pain threshold index in a hot-plate test were assessed. Results: The dosages of the amino acids administered with bicuculline had no effect on motor behavior in conscious mice. Glycine or muscimol reduced bicuculline-induced allodynia regardless of the administration site, whereas intrathecal taurine reduced bicuculline-induced allodynia. Glycine, taurine, and muscimol all antagonized the effects induced by bicuculline in the hot-plate test, regardless of the administration site. Conclusion: Glycine, taurine, and muscimol were found to have anti-allodynic and anti-thermal hyperalgesic properties in vivo. These observations suggest an interaction between glycine and GABA receptors during the regulation of antinociception.

Original languageEnglish
Pages (from-to)907-914
Number of pages8
JournalActa Pharmacologica Sinica
Volume31
Issue number8
DOIs
Publication statusPublished - 2010 Aug 1

Fingerprint

Muscimol
Bicuculline
Taurine
Hyperalgesia
Glycine
Glycine Receptors
Inbred ICR Mouse
Pain Threshold
GABA Receptors
Touch
Analgesia
gamma-Aminobutyric Acid
Central Nervous System
Hot Temperature
Amino Acids

Keywords

  • allodynia
  • bicuculline
  • glycine
  • hyperalgesia
  • intracisternal
  • intrathecal drug delivery

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Cite this

Intracisternal or intrathecal glycine, taurine, or muscimol inhibit bicuculline-induced allodynia and thermal hyperalgesia in mice. / Lee, Il Ok; Lim, Eui Sung.

In: Acta Pharmacologica Sinica, Vol. 31, No. 8, 01.08.2010, p. 907-914.

Research output: Contribution to journalArticle

@article{d205bf8bf92b4bd4ad4082cb9b82fa47,
title = "Intracisternal or intrathecal glycine, taurine, or muscimol inhibit bicuculline-induced allodynia and thermal hyperalgesia in mice",
abstract = "Aim: To investigate the effects of GABA and glycine on analgesia in the central nervous system.Methods:Glycine, taurine, or muscimol was injected with bicuculline into the cistern magna or the lumbar subarachnoidal space in ICR mice. The effects on bicuculline-induced allodynia in a touch-evoked agitation test and on pain threshold index in a hot-plate test were assessed. Results: The dosages of the amino acids administered with bicuculline had no effect on motor behavior in conscious mice. Glycine or muscimol reduced bicuculline-induced allodynia regardless of the administration site, whereas intrathecal taurine reduced bicuculline-induced allodynia. Glycine, taurine, and muscimol all antagonized the effects induced by bicuculline in the hot-plate test, regardless of the administration site. Conclusion: Glycine, taurine, and muscimol were found to have anti-allodynic and anti-thermal hyperalgesic properties in vivo. These observations suggest an interaction between glycine and GABA receptors during the regulation of antinociception.",
keywords = "allodynia, bicuculline, glycine, hyperalgesia, intracisternal, intrathecal drug delivery",
author = "Lee, {Il Ok} and Lim, {Eui Sung}",
year = "2010",
month = "8",
day = "1",
doi = "10.1038/aps.2010.82",
language = "English",
volume = "31",
pages = "907--914",
journal = "Acta Pharmacologica Sinica",
issn = "1671-4083",
publisher = "Nature Publishing Group",
number = "8",

}

TY - JOUR

T1 - Intracisternal or intrathecal glycine, taurine, or muscimol inhibit bicuculline-induced allodynia and thermal hyperalgesia in mice

AU - Lee, Il Ok

AU - Lim, Eui Sung

PY - 2010/8/1

Y1 - 2010/8/1

N2 - Aim: To investigate the effects of GABA and glycine on analgesia in the central nervous system.Methods:Glycine, taurine, or muscimol was injected with bicuculline into the cistern magna or the lumbar subarachnoidal space in ICR mice. The effects on bicuculline-induced allodynia in a touch-evoked agitation test and on pain threshold index in a hot-plate test were assessed. Results: The dosages of the amino acids administered with bicuculline had no effect on motor behavior in conscious mice. Glycine or muscimol reduced bicuculline-induced allodynia regardless of the administration site, whereas intrathecal taurine reduced bicuculline-induced allodynia. Glycine, taurine, and muscimol all antagonized the effects induced by bicuculline in the hot-plate test, regardless of the administration site. Conclusion: Glycine, taurine, and muscimol were found to have anti-allodynic and anti-thermal hyperalgesic properties in vivo. These observations suggest an interaction between glycine and GABA receptors during the regulation of antinociception.

AB - Aim: To investigate the effects of GABA and glycine on analgesia in the central nervous system.Methods:Glycine, taurine, or muscimol was injected with bicuculline into the cistern magna or the lumbar subarachnoidal space in ICR mice. The effects on bicuculline-induced allodynia in a touch-evoked agitation test and on pain threshold index in a hot-plate test were assessed. Results: The dosages of the amino acids administered with bicuculline had no effect on motor behavior in conscious mice. Glycine or muscimol reduced bicuculline-induced allodynia regardless of the administration site, whereas intrathecal taurine reduced bicuculline-induced allodynia. Glycine, taurine, and muscimol all antagonized the effects induced by bicuculline in the hot-plate test, regardless of the administration site. Conclusion: Glycine, taurine, and muscimol were found to have anti-allodynic and anti-thermal hyperalgesic properties in vivo. These observations suggest an interaction between glycine and GABA receptors during the regulation of antinociception.

KW - allodynia

KW - bicuculline

KW - glycine

KW - hyperalgesia

KW - intracisternal

KW - intrathecal drug delivery

UR - http://www.scopus.com/inward/record.url?scp=77955459344&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77955459344&partnerID=8YFLogxK

U2 - 10.1038/aps.2010.82

DO - 10.1038/aps.2010.82

M3 - Article

VL - 31

SP - 907

EP - 914

JO - Acta Pharmacologica Sinica

JF - Acta Pharmacologica Sinica

SN - 1671-4083

IS - 8

ER -