TY - JOUR
T1 - Intracoronary thrombus formation after drug-eluting stents implantation
T2 - Optical coherence tomographic study
AU - Kim, Jung Sun
AU - Hong, Myeong Ki
AU - Fan, Chunyu
AU - Kim, Tae Hoon
AU - Shim, Jae Min
AU - Park, Sang Min
AU - Ko, Young Guk
AU - Choi, Donghoon
AU - Jang, Yangsoo
N1 - Funding Information:
This study was partly supported by a grant of the Korea Health care technology R&D Project, Ministry for Health, Welfare & Family Affairs, Republic of Korea (no. A085012 and A000385 ), a grant of the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea (no. A085136 ), and the Cardiovascular Research Center, Seoul, Korea .
PY - 2010/2
Y1 - 2010/2
N2 - Background: Intracoronary thrombus formation after drug-eluting stent (DES) implantation is not sufficiently evaluated. Methods: Optical coherence tomography (OCT) was performed in 226 patients (total DES n = 244, sirolimus-eluting stent [SES] n = 95, paclitaxel-eluting stent [PES] n = 62, zotarolimus-eluting stent [ZES] n = 87) after implantation (mean 11 months, range 3-66 months). Using OCT, we investigated the incidence and determinants of intracoronary thrombus. Results: Intracoronary thrombus was detected in 35 (14%) cases (27 SES [28%], 7 PES [11%], and 1 ZES [1%], P < .001) and was associated with longer stent, smaller stent diameter, and stents at bifurcation lesions. More uncovered stent struts (26 ± 23 vs 8 ± 17, P < .001) and malapposed stent struts (6 ± 14 vs 2 ± 6, P < .001) were also associated with intracoronary thrombus. Multiple logistic regression analysis found the following determinants of intracoronary thrombus: stent length ≥28 mm (odds ratio [OR] 7.31, 95% CI 1.79-29.86, P = .01), stent diameter <3.0 mm (OR 4.38, 95% CI 1.38-13.97, P = .01), and ≥8 uncovered struts in each stent (OR 3.29, 95% CI 1.07-10.17, P = .04). Conclusions: Length, size, and types of DES may be more important than clinical factors in intracoronary thrombus formation after DES implantations.
AB - Background: Intracoronary thrombus formation after drug-eluting stent (DES) implantation is not sufficiently evaluated. Methods: Optical coherence tomography (OCT) was performed in 226 patients (total DES n = 244, sirolimus-eluting stent [SES] n = 95, paclitaxel-eluting stent [PES] n = 62, zotarolimus-eluting stent [ZES] n = 87) after implantation (mean 11 months, range 3-66 months). Using OCT, we investigated the incidence and determinants of intracoronary thrombus. Results: Intracoronary thrombus was detected in 35 (14%) cases (27 SES [28%], 7 PES [11%], and 1 ZES [1%], P < .001) and was associated with longer stent, smaller stent diameter, and stents at bifurcation lesions. More uncovered stent struts (26 ± 23 vs 8 ± 17, P < .001) and malapposed stent struts (6 ± 14 vs 2 ± 6, P < .001) were also associated with intracoronary thrombus. Multiple logistic regression analysis found the following determinants of intracoronary thrombus: stent length ≥28 mm (odds ratio [OR] 7.31, 95% CI 1.79-29.86, P = .01), stent diameter <3.0 mm (OR 4.38, 95% CI 1.38-13.97, P = .01), and ≥8 uncovered struts in each stent (OR 3.29, 95% CI 1.07-10.17, P = .04). Conclusions: Length, size, and types of DES may be more important than clinical factors in intracoronary thrombus formation after DES implantations.
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U2 - 10.1016/j.ahj.2009.11.029
DO - 10.1016/j.ahj.2009.11.029
M3 - Article
C2 - 20152227
AN - SCOPUS:75249103029
VL - 159
SP - 278
EP - 283
JO - American Heart Journal
JF - American Heart Journal
SN - 0002-8703
IS - 2
ER -