Intracranial Aneurysms in Adult Moyamoya Disease

Jang Hun Kim, Taek-Hyun Kwon, Jong Hyun Kim, Kyuha Chong, Wonki Yoon

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background The prevalence of aneurysm formation in adults with moyamoya disease (MMD) is approximately 14%, and it represents a major potential hemorrhagic risk. We aimed to study the characteristics of intracranial aneurysms occurring in patients with MMD. We retrospectively reviewed our 10-year experience of patients with intracranial aneurysms and a diagnosis of MMD at our hospital. Methods Imaging studies and clinical records of 211 patients who were admitted to our hospital between January 2007 and December 2016 and were diagnosed with MMD were retrospectively reviewed. Patients were divided into 2 groups: 1) MMD without intracranial aneurysms and 2) MMD with intracranial aneurysms. The 2 groups were compared using statistical analysis. Angiographic findings and clinical features of MMD-associated aneurysms were reviewed. Results There were significant differences between the 2 groups, including age and clinical presentation. Among all enrolled patients (N = 132), 11 aneurysms were discovered in 11 patients. Prevalence of intracranial aneurysms in patients with MMD was 8.3%, and the rupture rate of these aneurysms was 63.6%. We classified the 10 MMD-associated aneurysms (excluding 1 incidentally found paraclinoid aneurysm) as follows: 4 dissecting aneurysms or pseudoaneurysms and 6 hemodynamic true aneurysms. Conclusions MMD-associated intracranial aneurysms frequently occur in patients presenting with hemorrhagic MMD and are associated with an extremely high rate of rupture. Long-standing hemodynamic stress as well as pathologic and anatomic factors might contribute to the formation of an aneurysm.

Original languageEnglish
Pages (from-to)e175-e182
JournalWorld Neurosurgery
Volume109
DOIs
Publication statusPublished - 2018 Jan 1

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Moyamoya Disease
Intracranial Aneurysm
Aneurysm
Rupture
Hemodynamics
Dissecting Aneurysm
False Aneurysm
Age Groups

Keywords

  • Intracranial aneurysm
  • Moyamoya disease
  • Moyamoya-associated aneurysm
  • Pseudoaneurysm

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

Intracranial Aneurysms in Adult Moyamoya Disease. / Kim, Jang Hun; Kwon, Taek-Hyun; Kim, Jong Hyun; Chong, Kyuha; Yoon, Wonki.

In: World Neurosurgery, Vol. 109, 01.01.2018, p. e175-e182.

Research output: Contribution to journalArticle

Kim, Jang Hun ; Kwon, Taek-Hyun ; Kim, Jong Hyun ; Chong, Kyuha ; Yoon, Wonki. / Intracranial Aneurysms in Adult Moyamoya Disease. In: World Neurosurgery. 2018 ; Vol. 109. pp. e175-e182.
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abstract = "Background The prevalence of aneurysm formation in adults with moyamoya disease (MMD) is approximately 14{\%}, and it represents a major potential hemorrhagic risk. We aimed to study the characteristics of intracranial aneurysms occurring in patients with MMD. We retrospectively reviewed our 10-year experience of patients with intracranial aneurysms and a diagnosis of MMD at our hospital. Methods Imaging studies and clinical records of 211 patients who were admitted to our hospital between January 2007 and December 2016 and were diagnosed with MMD were retrospectively reviewed. Patients were divided into 2 groups: 1) MMD without intracranial aneurysms and 2) MMD with intracranial aneurysms. The 2 groups were compared using statistical analysis. Angiographic findings and clinical features of MMD-associated aneurysms were reviewed. Results There were significant differences between the 2 groups, including age and clinical presentation. Among all enrolled patients (N = 132), 11 aneurysms were discovered in 11 patients. Prevalence of intracranial aneurysms in patients with MMD was 8.3{\%}, and the rupture rate of these aneurysms was 63.6{\%}. We classified the 10 MMD-associated aneurysms (excluding 1 incidentally found paraclinoid aneurysm) as follows: 4 dissecting aneurysms or pseudoaneurysms and 6 hemodynamic true aneurysms. Conclusions MMD-associated intracranial aneurysms frequently occur in patients presenting with hemorrhagic MMD and are associated with an extremely high rate of rupture. Long-standing hemodynamic stress as well as pathologic and anatomic factors might contribute to the formation of an aneurysm.",
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N2 - Background The prevalence of aneurysm formation in adults with moyamoya disease (MMD) is approximately 14%, and it represents a major potential hemorrhagic risk. We aimed to study the characteristics of intracranial aneurysms occurring in patients with MMD. We retrospectively reviewed our 10-year experience of patients with intracranial aneurysms and a diagnosis of MMD at our hospital. Methods Imaging studies and clinical records of 211 patients who were admitted to our hospital between January 2007 and December 2016 and were diagnosed with MMD were retrospectively reviewed. Patients were divided into 2 groups: 1) MMD without intracranial aneurysms and 2) MMD with intracranial aneurysms. The 2 groups were compared using statistical analysis. Angiographic findings and clinical features of MMD-associated aneurysms were reviewed. Results There were significant differences between the 2 groups, including age and clinical presentation. Among all enrolled patients (N = 132), 11 aneurysms were discovered in 11 patients. Prevalence of intracranial aneurysms in patients with MMD was 8.3%, and the rupture rate of these aneurysms was 63.6%. We classified the 10 MMD-associated aneurysms (excluding 1 incidentally found paraclinoid aneurysm) as follows: 4 dissecting aneurysms or pseudoaneurysms and 6 hemodynamic true aneurysms. Conclusions MMD-associated intracranial aneurysms frequently occur in patients presenting with hemorrhagic MMD and are associated with an extremely high rate of rupture. Long-standing hemodynamic stress as well as pathologic and anatomic factors might contribute to the formation of an aneurysm.

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KW - Intracranial aneurysm

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