Intraocular application of gold nanodisks optically tuned for optical coherence tomography

inhibitory effect on retinal neovascularization without unbearable toxicity

Hyun Beom Song, Jung Sub Wi, Dong Hyun Jo, Jin Hyoung Kim, Sang-Won Lee, Tae Geol Lee, Jeong Hun Kim

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Bare gold nanospheres have been shown to have anti-angiogenic effects but are optically unfavorable because their resonant wavelength lies in the visible spectrum. Here, we design gold nanodisks with a higher scattering capability than gold nanorods and with a resonant wavelength at near-infrared region – the area where the source of light utilized by optical coherence tomography (OCT) lies. With a physical synthesis system, we then fabricate 160-nm-sized gold nanodisks exhibiting resonant wavelength at 830 nm. The synthesized nanoparticles were successfully visualized in in vivo OCT at concentrations as low as 1 pM. After demonstrating their binding ability to vascular endothelial growth factor (VEGF), we show that they suppress VEGF-induced migration of endothelial cells. Finally, we demonstrate that intravitreally injected gold nanodisks attenuate neovascularization of oxygen-induced retinopathy in mice, in a dose dependent manner, such that they are cleared from the vitreous within 2 weeks without histologic or electrophysiologic toxicity.

Original languageEnglish
Pages (from-to)1901-1911
Number of pages11
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Volume13
Issue number6
DOIs
Publication statusPublished - 2017 Aug 1
Externally publishedYes

Fingerprint

Retinal Neovascularization
Optical tomography
Optical Coherence Tomography
Gold
Toxicity
Wavelength
Vascular Endothelial Growth Factor A
Nanospheres
Nanotubes
Endothelial cells
Nanorods
Nanoparticles
Light sources
Endothelial Cells
Scattering
Oxygen
Infrared radiation
Light

Keywords

  • Angiogenesis inhibitor
  • Gold nanodisk
  • Intraocular application
  • Near-infrared
  • Optical coherence tomography
  • Retinal neovascularization

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Bioengineering
  • Biomedical Engineering
  • Molecular Medicine
  • Materials Science(all)
  • Pharmaceutical Science

Cite this

Intraocular application of gold nanodisks optically tuned for optical coherence tomography : inhibitory effect on retinal neovascularization without unbearable toxicity. / Song, Hyun Beom; Wi, Jung Sub; Jo, Dong Hyun; Kim, Jin Hyoung; Lee, Sang-Won; Lee, Tae Geol; Kim, Jeong Hun.

In: Nanomedicine: Nanotechnology, Biology, and Medicine, Vol. 13, No. 6, 01.08.2017, p. 1901-1911.

Research output: Contribution to journalArticle

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