Intraocular application of gold nanodisks optically tuned for optical coherence tomography: inhibitory effect on retinal neovascularization without unbearable toxicity

Hyun Beom Song, Jung Sub Wi, Dong Hyun Jo, Jin Hyoung Kim, Sang Won Lee, Tae Geol Lee, Jeong Hun Kim

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Bare gold nanospheres have been shown to have anti-angiogenic effects but are optically unfavorable because their resonant wavelength lies in the visible spectrum. Here, we design gold nanodisks with a higher scattering capability than gold nanorods and with a resonant wavelength at near-infrared region – the area where the source of light utilized by optical coherence tomography (OCT) lies. With a physical synthesis system, we then fabricate 160-nm-sized gold nanodisks exhibiting resonant wavelength at 830 nm. The synthesized nanoparticles were successfully visualized in in vivo OCT at concentrations as low as 1 pM. After demonstrating their binding ability to vascular endothelial growth factor (VEGF), we show that they suppress VEGF-induced migration of endothelial cells. Finally, we demonstrate that intravitreally injected gold nanodisks attenuate neovascularization of oxygen-induced retinopathy in mice, in a dose dependent manner, such that they are cleared from the vitreous within 2 weeks without histologic or electrophysiologic toxicity.

Original languageEnglish
Pages (from-to)1901-1911
Number of pages11
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Volume13
Issue number6
DOIs
Publication statusPublished - 2017 Aug
Externally publishedYes

Keywords

  • Angiogenesis inhibitor
  • Gold nanodisk
  • Intraocular application
  • Near-infrared
  • Optical coherence tomography
  • Retinal neovascularization

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Molecular Medicine
  • Biomedical Engineering
  • Materials Science(all)
  • Pharmaceutical Science

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