Invasive pulmonary aspergillosis after living donor liver transplantation should be eradicated or not? A case report

J. W. Park, J. H. Kim, W. B. Kim, H. J. Han, S. B. Choi, J. E. Yeon, K. S. Byun, S. Y. Choi

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3 Citations (Scopus)

Abstract

Background: Invasive pulmonary aspergillosis (IPA) is a rare complication with a high mortality rate after organ transplantation. Early antifungal therapy improves survival. In some cases, surgical resection is necessary for a complete remission. We have reported herein a case of sustained (but stationary) IPA cured by the modulation of immunosuppression with discontinuation of antifungal therapy. Case: A 34-year-old man underwent liver transplantation experiencing are early bile leak and an acute rejection episode. Steroid pulse therapy was accompanied by intensified immunosuppression. After a week he developed intermittent hemoptysis, which was treated with antibiotics due to a diagnosis of pneumonia by chest X ray. Meanwhile the bile leak progressed to a huge biloma at reoperation 3 weeks after the initial operation he was converted from a choledochocholedochostomy to a hepaticojejunostomy. After 1 week, follow-up chest X ray showed the lesion had progressed to form an abscess. Subsequent chest computed tomography (CT) detected a pulmonary mass with internal necrosis and CT-guided lung biopsy revealed Aspergillus fumigatus on isolation. Antifungal therapy with voriconazole and/or amphotericin B for 3 months stopped disease progression but the lesion was sustained. We stopped antifungal therapy due to side effects and reduced the intensity of immunosuppression. Follow-up chest CT 5 months later showed improvement with a persistent cavitary lesion containing a fungal ball. However, after 9 months, there was no focal lesion in either lung. This unusual case of IPA was cured by reducing immunosuppression without antifungal therapy. Conclusion: IPA should be eradicated with prompt antifugal therapy, but stationary IPA can be observed cautiously while reducing immunosuppression.

Original languageEnglish
Pages (from-to)2428-2430
Number of pages3
JournalTransplantation Proceedings
Volume43
Issue number6
DOIs
Publication statusPublished - 2011 Jul

ASJC Scopus subject areas

  • Surgery
  • Transplantation

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    Park, J. W., Kim, J. H., Kim, W. B., Han, H. J., Choi, S. B., Yeon, J. E., Byun, K. S., & Choi, S. Y. (2011). Invasive pulmonary aspergillosis after living donor liver transplantation should be eradicated or not? A case report. Transplantation Proceedings, 43(6), 2428-2430. https://doi.org/10.1016/j.transproceed.2011.05.034