Investigating the in vitro osteogenic properties of the inclusion nanocarrier of icariin with beta-cyclodextrin-alginate

Somang Choi, Yeong Seok Lee, Han Saem Jo, Woong Kyo Jeong, Hak Jun Kim, Mi Hyun Song, Kyeongsoon Park, Sung Eun Kim

    Research output: Contribution to journalArticlepeer-review

    1 Citation (Scopus)

    Abstract

    In this study, we created an inclusion nanocarrier of icariin (ICA) and β-cyclodextrin-alginate conjugate (ICA/β-CD-ALG) and determined its in vitro osteogenic ability on MC3T3-E1 cells. The morphological shape of the prepared β-CD-ALG with or without ICA was nano-sized and round. The use of β-CD-ALG achieved a sustained ICA release for up to 7 days. In vitro studies found that ICA/β-CD-ALG had a greater potential in osteogenesis on MC3T3-E1 cells compared to β-CD-ALG by exhibiting both higher alkaline phosphatase levels and the amount of calcium deposits. Moreover, ICA/β-CD-ALG greatly increased the levels of osteogenesis markers including osteocalcin (OCN) and osteopontin (OPN). Our results suggest that ICA/β-CD-ALG plays a significant role in cellular osteogenic activity.

    Original languageEnglish
    Article number4137
    JournalApplied Sciences (Switzerland)
    Volume10
    Issue number12
    DOIs
    Publication statusPublished - 2020 Jun 1

    Keywords

    • Drug delivery
    • Icariin
    • MC3T3
    • Osteogenic activity
    • β-cyclodextrin-alginate

    ASJC Scopus subject areas

    • Materials Science(all)
    • Instrumentation
    • Engineering(all)
    • Process Chemistry and Technology
    • Computer Science Applications
    • Fluid Flow and Transfer Processes

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