Investigation of d -Amino Acid-Based Surfactants and Nanocomposites with Gold and Silica Nanoparticles as against Multidrug-Resistant Bacteria Agents

Jae Ho Shim, Sungduk Gwak, Byung Kook Ahn, Hogyu Han, Yeonsun Hong, Ok Sarah Shin

Research output: Contribution to journalArticlepeer-review

Abstract

d-amino acid-based surfactants (d-AASs) were synthesized and their antimicrobial activity was evaluated. N-α-lauroyl-d-arginine ethyl ester hydrochloride (d-LAE), d-proline dodecyl ester (d-PD), and d-alanine dodecyl ester (d-AD) were found to have antibacterial activity against both Gram-positive and -negative bacteria, but less efficacy against Gram-negative bacteria. For these reasons, combining antimicrobial agents with nanoparticles is a promising technique for improving their antibacterial properties to eliminate drug-resistant pathogens. d-LAE coated on gold (AuNP) and silica (SiNP) nanoparticles has more efficient antibacterial activity than that of d-LAE alone. However, unlike d-LAE, d-PD has enhanced antibacterial activity upon being coated on AuNP. The antibacterial d-AASs and their nanocomposites with nanoparticles were synthesized in an environmentally friendly manner and are expected to be valuable new antimicrobial agents against multidrug-resistant (MDR) pathogens.

Original languageEnglish
Pages (from-to)46146-46155
Number of pages10
JournalACS Omega
Volume7
Issue number50
DOIs
Publication statusPublished - 2022 Dec 20

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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