TY - JOUR
T1 - Investigation of entrapped pore in the pastilles by a mercury porosimetery technique
AU - Kim, Jung Woo
AU - Cheon, Yang Ho
AU - Donchev, Danail
AU - Kim, Sung Hyun
AU - Ulrich, Joachim
PY - 2005/1/20
Y1 - 2005/1/20
N2 - The pore in pastilles was investigated which are produced by a pastillation technology. Mercury intrusion porosimeter and scanning electron microscopy (SEM) techniques were used for the investigation. The formation of micro-pores and cracks were in dependence of the manufacturing conditions of the pastilles (final impacting velocity, degree of subcooling and surface roughness of cooled substrate). The total pore is decreased with decreasing degree of subcooling, final impacting velocity and surface roughness of the cooled substrate. In order to design a drug delivery system and to select an optimum manufacturing parameter the relationship between overall growth rate of the pastilles and total pore was experimentally investigated. The total pore increased with increasing the overall growth rate of pastilles.
AB - The pore in pastilles was investigated which are produced by a pastillation technology. Mercury intrusion porosimeter and scanning electron microscopy (SEM) techniques were used for the investigation. The formation of micro-pores and cracks were in dependence of the manufacturing conditions of the pastilles (final impacting velocity, degree of subcooling and surface roughness of cooled substrate). The total pore is decreased with decreasing degree of subcooling, final impacting velocity and surface roughness of the cooled substrate. In order to design a drug delivery system and to select an optimum manufacturing parameter the relationship between overall growth rate of the pastilles and total pore was experimentally investigated. The total pore increased with increasing the overall growth rate of pastilles.
KW - Mercury intrusion porosimetry
KW - Pastillation technology
KW - Pastille
KW - Pore
UR - http://www.scopus.com/inward/record.url?scp=11144302570&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=11144302570&partnerID=8YFLogxK
U2 - 10.1016/j.ijpharm.2004.10.018
DO - 10.1016/j.ijpharm.2004.10.018
M3 - Article
C2 - 15620871
AN - SCOPUS:11144302570
SN - 0378-5173
VL - 288
SP - 305
EP - 314
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
IS - 2
ER -