Investigation of entrapped pore in the pastilles by a mercury porosimetery technique

Jung Woo Kim, Yang Ho Cheon, Danail Donchev, Sung Hyun Kim, Joachim Ulrich

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The pore in pastilles was investigated which are produced by a pastillation technology. Mercury intrusion porosimeter and scanning electron microscopy (SEM) techniques were used for the investigation. The formation of micro-pores and cracks were in dependence of the manufacturing conditions of the pastilles (final impacting velocity, degree of subcooling and surface roughness of cooled substrate). The total pore is decreased with decreasing degree of subcooling, final impacting velocity and surface roughness of the cooled substrate. In order to design a drug delivery system and to select an optimum manufacturing parameter the relationship between overall growth rate of the pastilles and total pore was experimentally investigated. The total pore increased with increasing the overall growth rate of pastilles.

Original languageEnglish
Pages (from-to)305-314
Number of pages10
JournalInternational Journal of Pharmaceutics
Volume288
Issue number2
DOIs
Publication statusPublished - 2005 Jan 20

Keywords

  • Mercury intrusion porosimetry
  • Pastillation technology
  • Pastille
  • Pore

ASJC Scopus subject areas

  • Pharmaceutical Science

Fingerprint Dive into the research topics of 'Investigation of entrapped pore in the pastilles by a mercury porosimetery technique'. Together they form a unique fingerprint.

  • Cite this