Investigation of molecular factors associated with malignant transformation of oligodendroglioma by proteomic study of a single case of rapid tumor progression

Chul Kee Park, Jin Hyun Kim, Min Jeong Moon, Ji Hye Jung, Su Young Lim, Sung Hye Park, Jong Hoon Kim, Dong Gyu Kim, Hee Won Jung, Byung Kyu Cho, Sun Ha Paek

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Purpose: Frozen tumor tissues from a patient who showed rapid progression to anaplastic oligodendroglioma after near total resection of oligodendroglioma were used to examine differential expression of proteins to gain better understanding of the pathogenesis of malignant transformation. Methods: We have determined their protein profiles using a 2D gel electrophoresis and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry approach. Results: Among 23 differentially expressed spots, overexpression of peroxiredoxin 6 and underexpression of rho GDP dissociation inhibitor alpha were confirmed to be valid after western blot and immunocytochemical analysis of oligodendroglioma tissue. Conclusions: Abnormal expression of peroxiredoxin 6 and rho GDP dissociation inhibitor alpha may be associated with malignant transformation in oligodendroglioma and these proteins might be candidates of molecular predictive factors.

Original languageEnglish
Pages (from-to)255-262
Number of pages8
JournalJournal of Cancer Research and Clinical Oncology
Volume134
Issue number2
DOIs
Publication statusPublished - 2008 Feb

Keywords

  • Malignant transformation
  • Mass spectrometry
  • Oligodendroglioma
  • Peroxiredoxin
  • Rho GDP dissociation inhibitor

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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