Investigation of possible epistatic interactions between GRIA2 and GRIA4 variants on clinical outcomes in patients with major depressive disorder

Alberto Chiesa, Loredana Lia, Claudia Lia, Soo Jung Lee, Changsu Han, Ashwin A. Patkar, Chi Un Pae, Alessandro Serretti

Research output: Contribution to journalArticle

6 Citations (Scopus)


Objectives: To investigate the effects of glutamate receptor, ionotropic, alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) 2 (GRIA2) rs4260586 and glutamate receptor, ionotropic, AMPA 4 (GRIA4) rs10736648 single nucleotide polymorphisms (SNPs) on response to antidepressants in Korean patients with major depressive disorder (MDD), and to ascertain whether epistatic interactions might exist between these SNPs. Methods: In this retrospective analysis, patients were assessed at hospital admission and discharge using the Montgomery-Åsberg depression rating scale (MADRS). A multiple regression model was employed to investigate the effects of the two SNP variants on clinical/sociodemographic outcomes relating to MDD. Results: Out of 145 Korean patients, the presence of both GRIA2 rs4260586 and GRIA4 rs10736648 polymorphisms had no significant association with MADRS improvement scores or other clinical/sociodemographic variables. Conclusions: These data potentially suggest a lack of epistatic interaction between GRIA2 and GRIA4 variants, regarding clinical outcomes in patients with MDD. The study was limited by small sample size, use of different antidepressants and incomplete coverage of genes under investigation.

Original languageEnglish
Pages (from-to)809-815
Number of pages7
JournalJournal of International Medical Research
Issue number3
Publication statusPublished - 2013 Jan 1



  • AMPA 2 (GRIA2)
  • AMPA 4 (GRIA4)
  • Glutamate receptor
  • epistasis
  • glutamate receptor
  • glutamatergic
  • ionotropic
  • major depression
  • single nucleotide polymorphism

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Biochemistry, medical

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