Investigation of precursor lesions of polypoidal choroidal vasculopathy using contralateral eye findings

the Korean Age-related Maculopathy Study (KARMS) Group

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Purpose: The purpose was to investigate precursor lesions of polypoidal choroidal vasculopathy (PCV). Methods: This cross-sectional study involved 276 unaffected contralateral eyes from unilateral PCV patients (Group 1), unilateral typical exudative age-related macular degeneration (AMD) patients (Group 2), and unilateral epiretinal membrane patients (Group 3) as age-matched controls. Grayish-yellow sub-retinal or sub-retinal-pigment-epithelial deposits larger than 63 μm in size with irregular but discrete margins were defined as drusen-like deposits (DLDs). The frequencies of DLDs, drusen, and pigmentary changes in each group were compared. Results: DLDs larger than 125 μm in size were found more frequently in Group 1 (19.5 %) than in Groups 2 (3.4 %) and 3 (3.2 %) (p < 0.001). Soft drusen were discovered more frequently in Group 2 eyes than in Groups 1 and 3 (p < 0.001). Pigmentary changes were found more frequently in Groups 1 and 2 compared to Group 3. Compared with the other groups, Group 1 manifested a higher frequency of choroidal vascular hyperpermeability (p < 0.005) and thicker choroid (p < 0.001). Conclusions: The precursor lesions of PCV are different from those of exudative AMD. DLDs larger than 125 μm and pigmentary changes may be early preclinical markers of PCV. Long-term longitudinal studies are warranted for validation.

Original languageEnglish
Pages (from-to)281-291
Number of pages11
JournalGraefe's Archive for Clinical and Experimental Ophthalmology
Volume255
Issue number2
DOIs
Publication statusPublished - 2017 Feb 1
Externally publishedYes

Fingerprint

Macular Degeneration
Epiretinal Membrane
Retinal Pigments
Choroid
Blood Vessels
Longitudinal Studies
Cross-Sectional Studies

Keywords

  • Age-related macular degeneration
  • Drusen-like deposit
  • Pigmentary change
  • Polypoidal choroidal vasculopathy

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Investigation of precursor lesions of polypoidal choroidal vasculopathy using contralateral eye findings. / the Korean Age-related Maculopathy Study (KARMS) Group.

In: Graefe's Archive for Clinical and Experimental Ophthalmology, Vol. 255, No. 2, 01.02.2017, p. 281-291.

Research output: Contribution to journalArticle

@article{cfb7c0f9e91e4026a29896c1878b359d,
title = "Investigation of precursor lesions of polypoidal choroidal vasculopathy using contralateral eye findings",
abstract = "Purpose: The purpose was to investigate precursor lesions of polypoidal choroidal vasculopathy (PCV). Methods: This cross-sectional study involved 276 unaffected contralateral eyes from unilateral PCV patients (Group 1), unilateral typical exudative age-related macular degeneration (AMD) patients (Group 2), and unilateral epiretinal membrane patients (Group 3) as age-matched controls. Grayish-yellow sub-retinal or sub-retinal-pigment-epithelial deposits larger than 63 μm in size with irregular but discrete margins were defined as drusen-like deposits (DLDs). The frequencies of DLDs, drusen, and pigmentary changes in each group were compared. Results: DLDs larger than 125 μm in size were found more frequently in Group 1 (19.5 {\%}) than in Groups 2 (3.4 {\%}) and 3 (3.2 {\%}) (p < 0.001). Soft drusen were discovered more frequently in Group 2 eyes than in Groups 1 and 3 (p < 0.001). Pigmentary changes were found more frequently in Groups 1 and 2 compared to Group 3. Compared with the other groups, Group 1 manifested a higher frequency of choroidal vascular hyperpermeability (p < 0.005) and thicker choroid (p < 0.001). Conclusions: The precursor lesions of PCV are different from those of exudative AMD. DLDs larger than 125 μm and pigmentary changes may be early preclinical markers of PCV. Long-term longitudinal studies are warranted for validation.",
keywords = "Age-related macular degeneration, Drusen-like deposit, Pigmentary change, Polypoidal choroidal vasculopathy",
author = "{the Korean Age-related Maculopathy Study (KARMS) Group} and Kang, {Se Woong} and Hoyoung Lee and Kunho Bae and Shin, {Joo Young} and Kim, {Sang Jin} and Kim, {Jong Min} and Kang, {Se Woong} and Kim, {Sang Jin} and Byeon, {Suk Ho} and Park, {Kyu Hyung} and Shin, {Jae Pil} and Yu, {Seung Young} and Jaeryung Oh and Oh, {Jae Ryung} and Kim, {Hyun Woong}",
year = "2017",
month = "2",
day = "1",
doi = "10.1007/s00417-016-3452-5",
language = "English",
volume = "255",
pages = "281--291",
journal = "Albrecht von Graefes Archiv für Klinische und Experimentelle Ophthalmologie",
issn = "0065-6100",
publisher = "Springer Verlag",
number = "2",

}

TY - JOUR

T1 - Investigation of precursor lesions of polypoidal choroidal vasculopathy using contralateral eye findings

AU - the Korean Age-related Maculopathy Study (KARMS) Group

AU - Kang, Se Woong

AU - Lee, Hoyoung

AU - Bae, Kunho

AU - Shin, Joo Young

AU - Kim, Sang Jin

AU - Kim, Jong Min

AU - Kang, Se Woong

AU - Kim, Sang Jin

AU - Byeon, Suk Ho

AU - Park, Kyu Hyung

AU - Shin, Jae Pil

AU - Yu, Seung Young

AU - Oh, Jaeryung

AU - Oh, Jae Ryung

AU - Kim, Hyun Woong

PY - 2017/2/1

Y1 - 2017/2/1

N2 - Purpose: The purpose was to investigate precursor lesions of polypoidal choroidal vasculopathy (PCV). Methods: This cross-sectional study involved 276 unaffected contralateral eyes from unilateral PCV patients (Group 1), unilateral typical exudative age-related macular degeneration (AMD) patients (Group 2), and unilateral epiretinal membrane patients (Group 3) as age-matched controls. Grayish-yellow sub-retinal or sub-retinal-pigment-epithelial deposits larger than 63 μm in size with irregular but discrete margins were defined as drusen-like deposits (DLDs). The frequencies of DLDs, drusen, and pigmentary changes in each group were compared. Results: DLDs larger than 125 μm in size were found more frequently in Group 1 (19.5 %) than in Groups 2 (3.4 %) and 3 (3.2 %) (p < 0.001). Soft drusen were discovered more frequently in Group 2 eyes than in Groups 1 and 3 (p < 0.001). Pigmentary changes were found more frequently in Groups 1 and 2 compared to Group 3. Compared with the other groups, Group 1 manifested a higher frequency of choroidal vascular hyperpermeability (p < 0.005) and thicker choroid (p < 0.001). Conclusions: The precursor lesions of PCV are different from those of exudative AMD. DLDs larger than 125 μm and pigmentary changes may be early preclinical markers of PCV. Long-term longitudinal studies are warranted for validation.

AB - Purpose: The purpose was to investigate precursor lesions of polypoidal choroidal vasculopathy (PCV). Methods: This cross-sectional study involved 276 unaffected contralateral eyes from unilateral PCV patients (Group 1), unilateral typical exudative age-related macular degeneration (AMD) patients (Group 2), and unilateral epiretinal membrane patients (Group 3) as age-matched controls. Grayish-yellow sub-retinal or sub-retinal-pigment-epithelial deposits larger than 63 μm in size with irregular but discrete margins were defined as drusen-like deposits (DLDs). The frequencies of DLDs, drusen, and pigmentary changes in each group were compared. Results: DLDs larger than 125 μm in size were found more frequently in Group 1 (19.5 %) than in Groups 2 (3.4 %) and 3 (3.2 %) (p < 0.001). Soft drusen were discovered more frequently in Group 2 eyes than in Groups 1 and 3 (p < 0.001). Pigmentary changes were found more frequently in Groups 1 and 2 compared to Group 3. Compared with the other groups, Group 1 manifested a higher frequency of choroidal vascular hyperpermeability (p < 0.005) and thicker choroid (p < 0.001). Conclusions: The precursor lesions of PCV are different from those of exudative AMD. DLDs larger than 125 μm and pigmentary changes may be early preclinical markers of PCV. Long-term longitudinal studies are warranted for validation.

KW - Age-related macular degeneration

KW - Drusen-like deposit

KW - Pigmentary change

KW - Polypoidal choroidal vasculopathy

UR - http://www.scopus.com/inward/record.url?scp=84991257426&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84991257426&partnerID=8YFLogxK

U2 - 10.1007/s00417-016-3452-5

DO - 10.1007/s00417-016-3452-5

M3 - Article

C2 - 27596850

AN - SCOPUS:84991257426

VL - 255

SP - 281

EP - 291

JO - Albrecht von Graefes Archiv für Klinische und Experimentelle Ophthalmologie

JF - Albrecht von Graefes Archiv für Klinische und Experimentelle Ophthalmologie

SN - 0065-6100

IS - 2

ER -