Investigation of the corticotropin-releasing hormone-proopiomelanocortin axis in various skin tumours

M. H. Kim, Dae Ho Cho, H. J. Kim, S. J. Chong, K. H. Lee, D. S. Yu, C. J. Park, J. Y. Lee, B. K. Cho, H. J. Park

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Abstract

Background: Various types of external stress cause the skin and central neuroendocrine system to express corticotropin-releasing hormone (CRH)-proopiomelanocortin (POMC) axis-related hormones. However, the precise role of the CRH-POMC axis-related hormones in various skin tumours is unclear. Objectives: This study examined expression patterns of the CRH-POMC axis-related hormones in skin tumours. Methods: The production of CRH, adrenocorticotropic hormone (ACTH) and α-melanocyte-stimulating hormone (α-MSH) in various tumour cell lines including HaCaT and primary keratinocytes was examined using an enzyme-linked immunosorbent assay. Immunohistochemical analysis of the skin tumours was also performed. Results: CRH, ACTH and α-MSH were strongly expressed in malignant skin tumour cell lines such as G-361 and DX-3 (both malignant melanoma, MM). However, normal and haematological malignancy cell lines did not express the CRH-POMC axis-related hormones. Immunohistochemical analysis of the skin tumours showed that MM (80%), squamous cell carcinoma (SCC, 70%) and basal cell carcinoma (BCC, 10%) had strong immunoreactivity (++/+++) for CRH. Strong ACTH and α-MSH expression was observed in MM (70% and 50%, respectively), SCC (80% and 60%, respectively) and BCC (70% and 50%, respectively). Conclusions: We report that an increase in the level of the CRH-POMC axis-related hormones is associated with malignant skin tumours such as MM. These results highlight the importance of the CRH-POMC axis-related hormones in the malignant tendency of skin tumours.

Original languageEnglish
Pages (from-to)910-915
Number of pages6
JournalBritish Journal of Dermatology
Volume155
Issue number5
DOIs
Publication statusPublished - 2006 Nov 1
Externally publishedYes

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Keywords

  • α-melanocyte- stimulating hormone
  • Adrenocorticotropic hormone
  • Corticotropin-releasing hormone
  • Corticotropin-releasing hormone-proopiomelanocortin axis
  • Skin tumour

ASJC Scopus subject areas

  • Dermatology

Cite this

Kim, M. H., Cho, D. H., Kim, H. J., Chong, S. J., Lee, K. H., Yu, D. S., Park, C. J., Lee, J. Y., Cho, B. K., & Park, H. J. (2006). Investigation of the corticotropin-releasing hormone-proopiomelanocortin axis in various skin tumours. British Journal of Dermatology, 155(5), 910-915. https://doi.org/10.1111/j.1365-2133.2006.07442.x