Abstract
Nobiletin contributes to pharmacological activities such as anti-cancer and anti-inflammatory effects, but little is known about its effect on melanogenesis. In this study, we found that nobiletin increased melanin content and tyrosinase activity in murine B16/F10 melanoma cells. Furthermore, inhibition of the extracellular signal-regulated kinase (ERK) pathway with U0216 resulted in inhibition of nobiletin-induced melanin synthesis and tyrosinase expression.
| Original language | English |
|---|---|
| Pages (from-to) | 1781-1784 |
| Number of pages | 4 |
| Journal | Bioscience, Biotechnology and Biochemistry |
| Volume | 71 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 2007 Sep 10 |
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Keywords
- Extracellular signal-regulated kinase (ERK)
- Melanogenesis
- Nobiletin
- Tyrosinase
ASJC Scopus subject areas
- Food Science
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Biotechnology
- Bioengineering
- Chemistry (miscellaneous)
- Applied Microbiology and Biotechnology
Cite this
Involvement of extracellular signal-regulated kinase in nobiletin-induced melanogenesis in murine B16/F10 melanoma cells. / Yoon, Hoon Seok; Lee, Sun Ryung; Ko, Hee Chul; Choi, Soo Youn; Park, Ji Gweon; Kim, Jeong Kook; Kim, Se J.
In: Bioscience, Biotechnology and Biochemistry, Vol. 71, No. 7, 10.09.2007, p. 1781-1784.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Involvement of extracellular signal-regulated kinase in nobiletin-induced melanogenesis in murine B16/F10 melanoma cells
AU - Yoon, Hoon Seok
AU - Lee, Sun Ryung
AU - Ko, Hee Chul
AU - Choi, Soo Youn
AU - Park, Ji Gweon
AU - Kim, Jeong Kook
AU - Kim, Se J.
PY - 2007/9/10
Y1 - 2007/9/10
N2 - Nobiletin contributes to pharmacological activities such as anti-cancer and anti-inflammatory effects, but little is known about its effect on melanogenesis. In this study, we found that nobiletin increased melanin content and tyrosinase activity in murine B16/F10 melanoma cells. Furthermore, inhibition of the extracellular signal-regulated kinase (ERK) pathway with U0216 resulted in inhibition of nobiletin-induced melanin synthesis and tyrosinase expression.
AB - Nobiletin contributes to pharmacological activities such as anti-cancer and anti-inflammatory effects, but little is known about its effect on melanogenesis. In this study, we found that nobiletin increased melanin content and tyrosinase activity in murine B16/F10 melanoma cells. Furthermore, inhibition of the extracellular signal-regulated kinase (ERK) pathway with U0216 resulted in inhibition of nobiletin-induced melanin synthesis and tyrosinase expression.
KW - Extracellular signal-regulated kinase (ERK)
KW - Melanogenesis
KW - Nobiletin
KW - Tyrosinase
UR - http://www.scopus.com/inward/record.url?scp=34548449361&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34548449361&partnerID=8YFLogxK
U2 - 10.1271/bbb.70088
DO - 10.1271/bbb.70088
M3 - Article
VL - 71
SP - 1781
EP - 1784
JO - Bioscience, Biotechnology and Biochemistry
JF - Bioscience, Biotechnology and Biochemistry
SN - 0916-8451
IS - 7
ER -