Involvement of extracellular signal-regulated kinase in nobiletin-induced melanogenesis in murine B16/F10 melanoma cells

Hoon Seok Yoon; Sun Ryung Lee; Hee Chul Ko; Soo Youn Choi; Ji Gweon Park; Jeong Kook Kim; Se Jae Kim

doi:10.1271/bbb.70088

Involvement of extracellular signal-regulated kinase in nobiletin-induced melanogenesis in murine B16/F10 melanoma cells

Hoon Seok Yoon, Sun Ryung Lee, Hee Chul Ko, Soo Youn Choi, Ji Gweon Park, Jeong Kook Kim, Se Jae Kim

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

Nobiletin contributes to pharmacological activities such as anti-cancer and anti-inflammatory effects, but little is known about its effect on melanogenesis. In this study, we found that nobiletin increased melanin content and tyrosinase activity in murine B16/F10 melanoma cells. Furthermore, inhibition of the extracellular signal-regulated kinase (ERK) pathway with U0216 resulted in inhibition of nobiletin-induced melanin synthesis and tyrosinase expression.

Original language	English
Pages (from-to)	1781-1784
Number of pages	4
Journal	Bioscience, Biotechnology and Biochemistry
Volume	71
Issue number	7
DOIs	https://doi.org/10.1271/bbb.70088
Publication status	Published - 2007

Keywords

Extracellular signal-regulated kinase (ERK)
Melanogenesis
Nobiletin
Tyrosinase

ASJC Scopus subject areas

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1271/bbb.70088

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title = "Involvement of extracellular signal-regulated kinase in nobiletin-induced melanogenesis in murine B16/F10 melanoma cells",

abstract = "Nobiletin contributes to pharmacological activities such as anti-cancer and anti-inflammatory effects, but little is known about its effect on melanogenesis. In this study, we found that nobiletin increased melanin content and tyrosinase activity in murine B16/F10 melanoma cells. Furthermore, inhibition of the extracellular signal-regulated kinase (ERK) pathway with U0216 resulted in inhibition of nobiletin-induced melanin synthesis and tyrosinase expression.",

keywords = "Extracellular signal-regulated kinase (ERK), Melanogenesis, Nobiletin, Tyrosinase",

author = "Yoon, {Hoon Seok} and Lee, {Sun Ryung} and Ko, {Hee Chul} and Choi, {Soo Youn} and Park, {Ji Gweon} and Kim, {Jeong Kook} and Kim, {Se Jae}",

note = "Funding Information: This study was supported by a Research Grant (2005) for Regional Industrial Technology Development from the Ministry of Commerce, Industry, and Energy of the Republic of Korea.",

year = "2007",

doi = "10.1271/bbb.70088",

language = "English",

volume = "71",

pages = "1781--1784",

journal = "Bioscience, Biotechnology and Biochemistry",

issn = "0916-8451",

publisher = "Japan Society for Bioscience Biotechnology and Agrochemistry",

number = "7",

}

TY - JOUR

T1 - Involvement of extracellular signal-regulated kinase in nobiletin-induced melanogenesis in murine B16/F10 melanoma cells

AU - Yoon, Hoon Seok

AU - Lee, Sun Ryung

AU - Ko, Hee Chul

AU - Choi, Soo Youn

AU - Park, Ji Gweon

AU - Kim, Jeong Kook

AU - Kim, Se Jae

N1 - Funding Information: This study was supported by a Research Grant (2005) for Regional Industrial Technology Development from the Ministry of Commerce, Industry, and Energy of the Republic of Korea.

PY - 2007

Y1 - 2007

N2 - Nobiletin contributes to pharmacological activities such as anti-cancer and anti-inflammatory effects, but little is known about its effect on melanogenesis. In this study, we found that nobiletin increased melanin content and tyrosinase activity in murine B16/F10 melanoma cells. Furthermore, inhibition of the extracellular signal-regulated kinase (ERK) pathway with U0216 resulted in inhibition of nobiletin-induced melanin synthesis and tyrosinase expression.

AB - Nobiletin contributes to pharmacological activities such as anti-cancer and anti-inflammatory effects, but little is known about its effect on melanogenesis. In this study, we found that nobiletin increased melanin content and tyrosinase activity in murine B16/F10 melanoma cells. Furthermore, inhibition of the extracellular signal-regulated kinase (ERK) pathway with U0216 resulted in inhibition of nobiletin-induced melanin synthesis and tyrosinase expression.

KW - Extracellular signal-regulated kinase (ERK)

KW - Melanogenesis

KW - Nobiletin

KW - Tyrosinase

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U2 - 10.1271/bbb.70088

DO - 10.1271/bbb.70088

M3 - Article

C2 - 17617702

AN - SCOPUS:34548449361

VL - 71

SP - 1781

EP - 1784

JO - Bioscience, Biotechnology and Biochemistry

JF - Bioscience, Biotechnology and Biochemistry

SN - 0916-8451

IS - 7

ER -

Involvement of extracellular signal-regulated kinase in nobiletin-induced melanogenesis in murine B16/F10 melanoma cells

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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