Involvement of extracellular signal-regulated kinase in nobiletin-induced melanogenesis in murine B16/F10 melanoma cells

Hoon Seok Yoon, Sun Ryung Lee, Hee Chul Ko, Soo Youn Choi, Ji Gweon Park, Jeong Kook Kim, Se J. Kim

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Nobiletin contributes to pharmacological activities such as anti-cancer and anti-inflammatory effects, but little is known about its effect on melanogenesis. In this study, we found that nobiletin increased melanin content and tyrosinase activity in murine B16/F10 melanoma cells. Furthermore, inhibition of the extracellular signal-regulated kinase (ERK) pathway with U0216 resulted in inhibition of nobiletin-induced melanin synthesis and tyrosinase expression.

Original languageEnglish
Pages (from-to)1781-1784
Number of pages4
JournalBioscience, Biotechnology and Biochemistry
Volume71
Issue number7
DOIs
Publication statusPublished - 2007 Sep 10

Fingerprint

Melanin
melanogenesis
Experimental Melanomas
Extracellular Signal-Regulated MAP Kinases
melanin
melanoma
mitogen-activated protein kinase
Monophenol Monooxygenase
Melanins
mice
anti-inflammatory activity
cells
neoplasms
synthesis
Anti-Inflammatory Agents
Pharmacology
nobiletin
Neoplasms

Keywords

  • Extracellular signal-regulated kinase (ERK)
  • Melanogenesis
  • Nobiletin
  • Tyrosinase

ASJC Scopus subject areas

  • Food Science
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Biotechnology
  • Bioengineering
  • Chemistry (miscellaneous)
  • Applied Microbiology and Biotechnology

Cite this

Involvement of extracellular signal-regulated kinase in nobiletin-induced melanogenesis in murine B16/F10 melanoma cells. / Yoon, Hoon Seok; Lee, Sun Ryung; Ko, Hee Chul; Choi, Soo Youn; Park, Ji Gweon; Kim, Jeong Kook; Kim, Se J.

In: Bioscience, Biotechnology and Biochemistry, Vol. 71, No. 7, 10.09.2007, p. 1781-1784.

Research output: Contribution to journalArticle

Yoon, Hoon Seok ; Lee, Sun Ryung ; Ko, Hee Chul ; Choi, Soo Youn ; Park, Ji Gweon ; Kim, Jeong Kook ; Kim, Se J. / Involvement of extracellular signal-regulated kinase in nobiletin-induced melanogenesis in murine B16/F10 melanoma cells. In: Bioscience, Biotechnology and Biochemistry. 2007 ; Vol. 71, No. 7. pp. 1781-1784.
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