Iodinated echogenic glycol chitosan nanoparticles for x-ray ct/us dual imaging of tumor

Daeil Choi, Sangmin Jeon, Dong Gil You, Wooram Um, Jeong Yeon Kim, Hong Yeol Yoon, Hyeyoun Chang, Dong Eog Kim, Jae Hyung Park, Hyuncheol Kim, Kwangmeyung Kim

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Development of biopolymer-based imaging agents which can access rapidly and provide detailed information about the diseases has received much attention as an alternative to conventional imaging agents. However, development of biopolymer-based nanomaterials for tumor imaging still remains challenging due to their low sensitivity and image resolution. To surmount of these limitations, multimodal imaging agents have been developed, and they were widely utilized for theranostic applications. Herein, iodine containing echogenic glycol chitosan nanoparticles are developed for x-ray computed tomography (CT) and ultrasound (US) imaging of tumor diagnosis. X-ray CT/US dual-modal imaging probe was prepared by following below two steps. First, iodine-contained diatrizoic acid (DTA) was chemically conjugated to the glycol chitosan (GC) for the CT imaging. DTA conjugated GC (GC-DTA NPs) formed stable nanoparticles with an average diameter of 315 nm. Second, perfluoropentane (PFP), a US imaging agent, was physically encapsulated into GC-DTA NPs by O/W emulsion method yielding GC-DTA-PFP nanoparticles (GC-DTA-PFP NPs). The GC-DTA-PFP NPs formed nanoparticles in physiological condition, and they presented the strong x-ray CT, and US signals in phantom test in vitro. Importantly, GC-DTA-PFP NPs were effectively accumulated on the tumor site by enhanced permeation and retention (EPR) effects. Moreover, GC-DTA-PFP NPs showed x-ray CT, and US signals in tumor tissues after intratumoral and intravenous injection, respectively. Therefore, GC-DTA-PFP NPs indicated that x-ray CT/US dual-modal imaging using iodinated echogenic nanoparticles could be provided more comprehensive and accurate diagnostic information to diagnosis of tumor.

Original languageEnglish
Pages (from-to)117-127
Number of pages11
JournalNanotheranostics
Volume2
Issue number2
DOIs
Publication statusPublished - 2018 Jan 1

Keywords

  • Computed tomography
  • Dual-modal imaging
  • Glycol chitosan nanoparticles
  • Tumor imaging
  • Ultrasound imaging

ASJC Scopus subject areas

  • Biotechnology
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

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  • Cite this

    Choi, D., Jeon, S., You, D. G., Um, W., Kim, J. Y., Yoon, H. Y., Chang, H., Kim, D. E., Park, J. H., Kim, H., & Kim, K. (2018). Iodinated echogenic glycol chitosan nanoparticles for x-ray ct/us dual imaging of tumor. Nanotheranostics, 2(2), 117-127. https://doi.org/10.7150/ntno.18643