Abstract
A novel iodinated chitosan-backboned conjugate (GC-I-Ce6) was designed and prepared to fabricate self-assembled biopolymeric nanoparticles with heavy atom-effected enhanced singlet oxygen generation as well as biological merits. The heavy atom-rich nature of the hydrophobic particle interior was characterized with X-ray absorption and the modified photophysical properties of a chemically embedded photosensitizer, chlorin e6 (Ce6). From the comparative spectroscopic studies as well as cellular and animal experiments, it has been shown that the self-assembled GC-I-Ce6 nanoparticles have enhanced capability of singlet oxygen generation by the intraparticle heavy-atom effect, along with high tumor targetability in vitro and in vivo thanks to the glycol chitosan-surfaced exterior with biocompatible, positively charged and tumor-homing characteristics. Actual efficacy improvement in the photodynamic therapy of a human breast cancer cell line (MDA-MB-231) demonstrates potential of our photophysically and pharmaceutically motivated hybrid bioconjugate approach for nanomedicine applications.
| Original language | English |
|---|---|
| Pages (from-to) | 1022-1028 |
| Number of pages | 7 |
| Journal | Bioconjugate Chemistry |
| Volume | 23 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2012 May 16 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biotechnology
- Bioengineering
- Organic Chemistry
- Pharmaceutical Science
- Biomedical Engineering
- Pharmacology
Cite this
Iodinated photosensitizing chitosan : Self-assembly into tumor-homing nanoparticles with enhanced singlet oxygen generation. / Lim, Chang Keun; Shin, Jiyoung; Kwon, Ick Chan; Jeong, Seo Young; Kim, Sehoon.
In: Bioconjugate Chemistry, Vol. 23, No. 5, 16.05.2012, p. 1022-1028.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Iodinated photosensitizing chitosan
T2 - Self-assembly into tumor-homing nanoparticles with enhanced singlet oxygen generation
AU - Lim, Chang Keun
AU - Shin, Jiyoung
AU - Kwon, Ick Chan
AU - Jeong, Seo Young
AU - Kim, Sehoon
PY - 2012/5/16
Y1 - 2012/5/16
N2 - A novel iodinated chitosan-backboned conjugate (GC-I-Ce6) was designed and prepared to fabricate self-assembled biopolymeric nanoparticles with heavy atom-effected enhanced singlet oxygen generation as well as biological merits. The heavy atom-rich nature of the hydrophobic particle interior was characterized with X-ray absorption and the modified photophysical properties of a chemically embedded photosensitizer, chlorin e6 (Ce6). From the comparative spectroscopic studies as well as cellular and animal experiments, it has been shown that the self-assembled GC-I-Ce6 nanoparticles have enhanced capability of singlet oxygen generation by the intraparticle heavy-atom effect, along with high tumor targetability in vitro and in vivo thanks to the glycol chitosan-surfaced exterior with biocompatible, positively charged and tumor-homing characteristics. Actual efficacy improvement in the photodynamic therapy of a human breast cancer cell line (MDA-MB-231) demonstrates potential of our photophysically and pharmaceutically motivated hybrid bioconjugate approach for nanomedicine applications.
AB - A novel iodinated chitosan-backboned conjugate (GC-I-Ce6) was designed and prepared to fabricate self-assembled biopolymeric nanoparticles with heavy atom-effected enhanced singlet oxygen generation as well as biological merits. The heavy atom-rich nature of the hydrophobic particle interior was characterized with X-ray absorption and the modified photophysical properties of a chemically embedded photosensitizer, chlorin e6 (Ce6). From the comparative spectroscopic studies as well as cellular and animal experiments, it has been shown that the self-assembled GC-I-Ce6 nanoparticles have enhanced capability of singlet oxygen generation by the intraparticle heavy-atom effect, along with high tumor targetability in vitro and in vivo thanks to the glycol chitosan-surfaced exterior with biocompatible, positively charged and tumor-homing characteristics. Actual efficacy improvement in the photodynamic therapy of a human breast cancer cell line (MDA-MB-231) demonstrates potential of our photophysically and pharmaceutically motivated hybrid bioconjugate approach for nanomedicine applications.
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UR - http://www.scopus.com/inward/citedby.url?scp=84861149172&partnerID=8YFLogxK
U2 - 10.1021/bc300012g
DO - 10.1021/bc300012g
M3 - Article
C2 - 22515499
AN - SCOPUS:84861149172
VL - 23
SP - 1022
EP - 1028
JO - Bioconjugate Chemistry
JF - Bioconjugate Chemistry
SN - 1043-1802
IS - 5
ER -