Abstract
An activity-guided fractionation procedure of the 70% aqueous EtOH extract from the roots of Patrinia scabra led to the isolation and characterization of five new iridoids, patriscabrins A-E (1-5), along with 13 known compounds. The structures of 1-5 were determined by interpretation of spectroscopic data, particularly by 1D and 2D NMR, ECD, and VCD studies. Thereafter, isolates were evaluated for their inhibitory effects on lipopolysaccharide-induced nitric oxide production in RAW 264.7 cells. Of these, the new iridoids 2 and 5 and the known lignan patrineolignan B (6) exhibited IC50 values of 14.7 to 17.8 μM.
| Original language | English |
|---|---|
| Pages (from-to) | 1468-1473 |
| Number of pages | 6 |
| Journal | Journal of Natural Products |
| Volume | 81 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2018 Jun 22 |
ASJC Scopus subject areas
- Analytical Chemistry
- Molecular Medicine
- Pharmacology
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry
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Lee, D. H., Shin, J. S., Kang, S. Y., Lee, S. B., Lee, J. S., Ryu, S. M., Lee, K. T., Lee, D., & Jang, D. S. (2018). Iridoids from the Roots of Patrinia scabra and Their Inhibitory Potential on LPS-Induced Nitric Oxide Production. Journal of Natural Products, 81(6), 1468-1473. https://doi.org/10.1021/acs.jnatprod.8b00229