Iridoids from the Roots of Patrinia scabra and Their Inhibitory Potential on LPS-Induced Nitric Oxide Production

Da Hye Lee, Ji Sun Shin, Shin Young Kang, Seung Bin Lee, Jin Su Lee, Seung Mok Ryu, Kyung Tae Lee, Dongho Lee, Dae Sik Jang

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

An activity-guided fractionation procedure of the 70% aqueous EtOH extract from the roots of Patrinia scabra led to the isolation and characterization of five new iridoids, patriscabrins A-E (1-5), along with 13 known compounds. The structures of 1-5 were determined by interpretation of spectroscopic data, particularly by 1D and 2D NMR, ECD, and VCD studies. Thereafter, isolates were evaluated for their inhibitory effects on lipopolysaccharide-induced nitric oxide production in RAW 264.7 cells. Of these, the new iridoids 2 and 5 and the known lignan patrineolignan B (6) exhibited IC50 values of 14.7 to 17.8 μM.

Original languageEnglish
Pages (from-to)1468-1473
Number of pages6
JournalJournal of Natural Products
Volume81
Issue number6
DOIs
Publication statusPublished - 2018 Jun 22

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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  • Cite this

    Lee, D. H., Shin, J. S., Kang, S. Y., Lee, S. B., Lee, J. S., Ryu, S. M., Lee, K. T., Lee, D., & Jang, D. S. (2018). Iridoids from the Roots of Patrinia scabra and Their Inhibitory Potential on LPS-Induced Nitric Oxide Production. Journal of Natural Products, 81(6), 1468-1473. https://doi.org/10.1021/acs.jnatprod.8b00229