Iridoids from the Roots of Patrinia scabra and Their Inhibitory Potential on LPS-Induced Nitric Oxide Production

Da Hye Lee; Ji Sun Shin; Shin Young Kang; Seung Bin Lee; Jin Su Lee; Seung Mok Ryu; Kyung Tae Lee; Dongho Lee; Dae Sik Jang

doi:10.1021/acs.jnatprod.8b00229

Iridoids from the Roots of Patrinia scabra and Their Inhibitory Potential on LPS-Induced Nitric Oxide Production

Da Hye Lee, Ji Sun Shin, Shin Young Kang, Seung Bin Lee, Jin Su Lee, Seung Mok Ryu, Kyung Tae Lee, Dongho Lee, Dae Sik Jang

Department of Biosystems and Biotechnology

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

An activity-guided fractionation procedure of the 70% aqueous EtOH extract from the roots of Patrinia scabra led to the isolation and characterization of five new iridoids, patriscabrins A-E (1-5), along with 13 known compounds. The structures of 1-5 were determined by interpretation of spectroscopic data, particularly by 1D and 2D NMR, ECD, and VCD studies. Thereafter, isolates were evaluated for their inhibitory effects on lipopolysaccharide-induced nitric oxide production in RAW 264.7 cells. Of these, the new iridoids 2 and 5 and the known lignan patrineolignan B (6) exhibited IC ₅₀ values of 14.7 to 17.8 μM.

Original language	English
Pages (from-to)	1468-1473
Number of pages	6
Journal	Journal of Natural Products
Volume	81
Issue number	6
DOIs	https://doi.org/10.1021/acs.jnatprod.8b00229
Publication status	Published - 2018 Jun 22

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/acs.jnatprod.8b00229

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title = "Iridoids from the Roots of Patrinia scabra and Their Inhibitory Potential on LPS-Induced Nitric Oxide Production",

abstract = " An activity-guided fractionation procedure of the 70% aqueous EtOH extract from the roots of Patrinia scabra led to the isolation and characterization of five new iridoids, patriscabrins A-E (1-5), along with 13 known compounds. The structures of 1-5 were determined by interpretation of spectroscopic data, particularly by 1D and 2D NMR, ECD, and VCD studies. Thereafter, isolates were evaluated for their inhibitory effects on lipopolysaccharide-induced nitric oxide production in RAW 264.7 cells. Of these, the new iridoids 2 and 5 and the known lignan patrineolignan B (6) exhibited IC 50 values of 14.7 to 17.8 μM. ",

author = "Lee, {Da Hye} and Shin, {Ji Sun} and Kang, {Shin Young} and Lee, {Seung Bin} and Lee, {Jin Su} and Ryu, {Seung Mok} and Lee, {Kyung Tae} and Dongho Lee and Jang, {Dae Sik}",

note = "Funding Information: This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2016R1D1A1B03930222). Publisher Copyright: {\textcopyright} 2018 American Chemical Society and American Society of Pharmacognosy.",

year = "2018",

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doi = "10.1021/acs.jnatprod.8b00229",

language = "English",

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T1 - Iridoids from the Roots of Patrinia scabra and Their Inhibitory Potential on LPS-Induced Nitric Oxide Production

AU - Lee, Da Hye

AU - Shin, Ji Sun

AU - Kang, Shin Young

AU - Lee, Seung Bin

AU - Lee, Jin Su

AU - Ryu, Seung Mok

AU - Lee, Kyung Tae

AU - Lee, Dongho

AU - Jang, Dae Sik

N1 - Funding Information: This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2016R1D1A1B03930222). Publisher Copyright: © 2018 American Chemical Society and American Society of Pharmacognosy.

PY - 2018/6/22

Y1 - 2018/6/22

N2 - An activity-guided fractionation procedure of the 70% aqueous EtOH extract from the roots of Patrinia scabra led to the isolation and characterization of five new iridoids, patriscabrins A-E (1-5), along with 13 known compounds. The structures of 1-5 were determined by interpretation of spectroscopic data, particularly by 1D and 2D NMR, ECD, and VCD studies. Thereafter, isolates were evaluated for their inhibitory effects on lipopolysaccharide-induced nitric oxide production in RAW 264.7 cells. Of these, the new iridoids 2 and 5 and the known lignan patrineolignan B (6) exhibited IC 50 values of 14.7 to 17.8 μM.

AB - An activity-guided fractionation procedure of the 70% aqueous EtOH extract from the roots of Patrinia scabra led to the isolation and characterization of five new iridoids, patriscabrins A-E (1-5), along with 13 known compounds. The structures of 1-5 were determined by interpretation of spectroscopic data, particularly by 1D and 2D NMR, ECD, and VCD studies. Thereafter, isolates were evaluated for their inhibitory effects on lipopolysaccharide-induced nitric oxide production in RAW 264.7 cells. Of these, the new iridoids 2 and 5 and the known lignan patrineolignan B (6) exhibited IC 50 values of 14.7 to 17.8 μM.

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VL - 81

SP - 1468

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JO - Journal of Natural Products

JF - Journal of Natural Products

SN - 0163-3864

IS - 6

ER -

Iridoids from the Roots of Patrinia scabra and Their Inhibitory Potential on LPS-Induced Nitric Oxide Production

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ASJC Scopus subject areas

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