Iristectorigenin B isolated from Belamcanda chinensis is a liver X receptor modulator that increases ABCA1 and ABCG1 expression in macrophage RAW 264.7 cells

Hee jin Jun, Minh Hien Hoang, Jin Woo Lee, Jia Yaoyao, Ji Hae Lee, Dongho Lee, Hak Ju Lee, Woo Duck Seo, Bang Yeon Hwang, Sung-Joon Lee

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17 Citations (Scopus)

Abstract

A novel liver X receptor (LXR) modulator, iristectorigenin B isolated from Belamcanda chinensis, stimulated the transcriptional activity of both LXR-α and LXR-β. In macrophages, iristectorigenin B suppressed cholesterol accumulation in a dose-dependent manner and induced the transcriptional activation of LXR-α/-β-responsive genes, ATP-binding cassette transporters A1 and G1. It did not induce hepatic lipid accumulation nor the expression of the lipogenesis genes sterol regulatory element-binding protein-1c, fatty acid synthase, and stearoyl-CoA desaturase-1. Iristectorigenin B thus is a dual-LXR agonist that regulates the expression of key genes in cholesterol homeostasis in macrophage cells without inducing hepatic lipid accumulation.

Original languageEnglish
Pages (from-to)2213-2221
Number of pages9
JournalBiotechnology Letters
Volume34
Issue number12
DOIs
Publication statusPublished - 2012 Nov 1

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Keywords

  • Belamcanda chinensis
  • Cholesterol
  • Iristectorigenin B
  • LXR modulator

ASJC Scopus subject areas

  • Biotechnology

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