Iristectorigenin B isolated from Belamcanda chinensis is a liver X receptor modulator that increases ABCA1 and ABCG1 expression in macrophage RAW 264.7 cells

Hee jin Jun, Minh Hien Hoang, Jin Woo Lee, Jia Yaoyao, Ji Hae Lee, Dongho Lee, Hak Ju Lee, Woo Duck Seo, Bang Yeon Hwang, Sung-Joon Lee

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

A novel liver X receptor (LXR) modulator, iristectorigenin B isolated from Belamcanda chinensis, stimulated the transcriptional activity of both LXR-α and LXR-β. In macrophages, iristectorigenin B suppressed cholesterol accumulation in a dose-dependent manner and induced the transcriptional activation of LXR-α/-β-responsive genes, ATP-binding cassette transporters A1 and G1. It did not induce hepatic lipid accumulation nor the expression of the lipogenesis genes sterol regulatory element-binding protein-1c, fatty acid synthase, and stearoyl-CoA desaturase-1. Iristectorigenin B thus is a dual-LXR agonist that regulates the expression of key genes in cholesterol homeostasis in macrophage cells without inducing hepatic lipid accumulation.

Original languageEnglish
Pages (from-to)2213-2221
Number of pages9
JournalBiotechnology Letters
Volume34
Issue number12
DOIs
Publication statusPublished - 2012 Nov 1

Fingerprint

Macrophages
Cholesterol
Stearoyl-CoA Desaturase
Sterol Regulatory Element Binding Protein 1
Lipids
Gene Expression
Fatty Acid Synthases
Lipogenesis
ATP-Binding Cassette Transporters
Liver
Transcriptional Activation
Homeostasis
Liver X Receptors
RAW 264.7 Cells
Genes

Keywords

  • Belamcanda chinensis
  • Cholesterol
  • Iristectorigenin B
  • LXR modulator

ASJC Scopus subject areas

  • Biotechnology

Cite this

Iristectorigenin B isolated from Belamcanda chinensis is a liver X receptor modulator that increases ABCA1 and ABCG1 expression in macrophage RAW 264.7 cells. / Jun, Hee jin; Hoang, Minh Hien; Lee, Jin Woo; Yaoyao, Jia; Lee, Ji Hae; Lee, Dongho; Lee, Hak Ju; Seo, Woo Duck; Hwang, Bang Yeon; Lee, Sung-Joon.

In: Biotechnology Letters, Vol. 34, No. 12, 01.11.2012, p. 2213-2221.

Research output: Contribution to journalArticle

Jun, Hee jin ; Hoang, Minh Hien ; Lee, Jin Woo ; Yaoyao, Jia ; Lee, Ji Hae ; Lee, Dongho ; Lee, Hak Ju ; Seo, Woo Duck ; Hwang, Bang Yeon ; Lee, Sung-Joon. / Iristectorigenin B isolated from Belamcanda chinensis is a liver X receptor modulator that increases ABCA1 and ABCG1 expression in macrophage RAW 264.7 cells. In: Biotechnology Letters. 2012 ; Vol. 34, No. 12. pp. 2213-2221.
@article{f4a19e408b7e4ec5983eb8c8436c09c6,
title = "Iristectorigenin B isolated from Belamcanda chinensis is a liver X receptor modulator that increases ABCA1 and ABCG1 expression in macrophage RAW 264.7 cells",
abstract = "A novel liver X receptor (LXR) modulator, iristectorigenin B isolated from Belamcanda chinensis, stimulated the transcriptional activity of both LXR-α and LXR-β. In macrophages, iristectorigenin B suppressed cholesterol accumulation in a dose-dependent manner and induced the transcriptional activation of LXR-α/-β-responsive genes, ATP-binding cassette transporters A1 and G1. It did not induce hepatic lipid accumulation nor the expression of the lipogenesis genes sterol regulatory element-binding protein-1c, fatty acid synthase, and stearoyl-CoA desaturase-1. Iristectorigenin B thus is a dual-LXR agonist that regulates the expression of key genes in cholesterol homeostasis in macrophage cells without inducing hepatic lipid accumulation.",
keywords = "Belamcanda chinensis, Cholesterol, Iristectorigenin B, LXR modulator",
author = "Jun, {Hee jin} and Hoang, {Minh Hien} and Lee, {Jin Woo} and Jia Yaoyao and Lee, {Ji Hae} and Dongho Lee and Lee, {Hak Ju} and Seo, {Woo Duck} and Hwang, {Bang Yeon} and Sung-Joon Lee",
year = "2012",
month = "11",
day = "1",
doi = "10.1007/s10529-012-1036-y",
language = "English",
volume = "34",
pages = "2213--2221",
journal = "Biotechnology Letters",
issn = "0141-5492",
publisher = "Springer Netherlands",
number = "12",

}

TY - JOUR

T1 - Iristectorigenin B isolated from Belamcanda chinensis is a liver X receptor modulator that increases ABCA1 and ABCG1 expression in macrophage RAW 264.7 cells

AU - Jun, Hee jin

AU - Hoang, Minh Hien

AU - Lee, Jin Woo

AU - Yaoyao, Jia

AU - Lee, Ji Hae

AU - Lee, Dongho

AU - Lee, Hak Ju

AU - Seo, Woo Duck

AU - Hwang, Bang Yeon

AU - Lee, Sung-Joon

PY - 2012/11/1

Y1 - 2012/11/1

N2 - A novel liver X receptor (LXR) modulator, iristectorigenin B isolated from Belamcanda chinensis, stimulated the transcriptional activity of both LXR-α and LXR-β. In macrophages, iristectorigenin B suppressed cholesterol accumulation in a dose-dependent manner and induced the transcriptional activation of LXR-α/-β-responsive genes, ATP-binding cassette transporters A1 and G1. It did not induce hepatic lipid accumulation nor the expression of the lipogenesis genes sterol regulatory element-binding protein-1c, fatty acid synthase, and stearoyl-CoA desaturase-1. Iristectorigenin B thus is a dual-LXR agonist that regulates the expression of key genes in cholesterol homeostasis in macrophage cells without inducing hepatic lipid accumulation.

AB - A novel liver X receptor (LXR) modulator, iristectorigenin B isolated from Belamcanda chinensis, stimulated the transcriptional activity of both LXR-α and LXR-β. In macrophages, iristectorigenin B suppressed cholesterol accumulation in a dose-dependent manner and induced the transcriptional activation of LXR-α/-β-responsive genes, ATP-binding cassette transporters A1 and G1. It did not induce hepatic lipid accumulation nor the expression of the lipogenesis genes sterol regulatory element-binding protein-1c, fatty acid synthase, and stearoyl-CoA desaturase-1. Iristectorigenin B thus is a dual-LXR agonist that regulates the expression of key genes in cholesterol homeostasis in macrophage cells without inducing hepatic lipid accumulation.

KW - Belamcanda chinensis

KW - Cholesterol

KW - Iristectorigenin B

KW - LXR modulator

UR - http://www.scopus.com/inward/record.url?scp=84868448474&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84868448474&partnerID=8YFLogxK

U2 - 10.1007/s10529-012-1036-y

DO - 10.1007/s10529-012-1036-y

M3 - Article

VL - 34

SP - 2213

EP - 2221

JO - Biotechnology Letters

JF - Biotechnology Letters

SN - 0141-5492

IS - 12

ER -