TY - JOUR
T1 - Iron metabolism-related genes and mitochondrial genes are induced during involution of mouse mammary gland
AU - Lee, Mijoung
AU - Kim, Hyungha
AU - Jeon, Deahyun
AU - Hwang, Intaek
AU - Choi, Bonghwan
AU - Myung, Kyuho
AU - Kim, Hyunggee
AU - Choi, Yunjaie
AU - Paik, Sanggi
AU - Baik, Myunggi
N1 - Funding Information:
This study was supported in part by the Genetic Engineering Research Program (1995), Ministry of Education, Korea, a grant (# 1-2-60) of the ’95 Good Health R&D Project, Ministry of Health & Welfare, R.O.K., and by a grant from KOSEF through the Hormone Research Center (HRC-96-0402).
PY - 1996/7/5
Y1 - 1996/7/5
N2 - To understand molecular mechanisms of mammary gland involution, several clones were isolated after the primary differential screening of a total 40,000 pfu of involution-specific cDNA library, and further characterized. The partial sequences and Northern analysis revealed that iron metalbolism-related genes and mitochondrial genes were induced during mammary gland involution. The expression of the lactoferrin gene was induced at involution days 1, 2, and 3. The expression of ferritin heavy chain gene was induced at involution days 1, 2, 3 and 4. Cytochrome oxidase subunit I and cytochrome oxidase subunit 2, genes were induced at involution days 4 and 7. The expression of cytochrome b gene was induced at involution day 7. These results imply that iron metabolism and mitochondrial function may be altered during mammary gland involution.
AB - To understand molecular mechanisms of mammary gland involution, several clones were isolated after the primary differential screening of a total 40,000 pfu of involution-specific cDNA library, and further characterized. The partial sequences and Northern analysis revealed that iron metalbolism-related genes and mitochondrial genes were induced during mammary gland involution. The expression of the lactoferrin gene was induced at involution days 1, 2, and 3. The expression of ferritin heavy chain gene was induced at involution days 1, 2, 3 and 4. Cytochrome oxidase subunit I and cytochrome oxidase subunit 2, genes were induced at involution days 4 and 7. The expression of cytochrome b gene was induced at involution day 7. These results imply that iron metabolism and mitochondrial function may be altered during mammary gland involution.
UR - http://www.scopus.com/inward/record.url?scp=0030570510&partnerID=8YFLogxK
U2 - 10.1006/bbrc.1996.1001
DO - 10.1006/bbrc.1996.1001
M3 - Article
C2 - 8694805
AN - SCOPUS:0030570510
SN - 0006-291X
VL - 224
SP - 164
EP - 168
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 1
ER -