Iron metabolism-related genes and mitochondrial genes are induced during involution of mouse mammary gland

Mijoung Lee, Hyungha Kim, Deahyun Jeon, Intaek Hwang, Bonghwan Choi, Kyuho Myung, Hyunggee Kim, Yunjaie Choi, Sanggi Paik, Myunggi Baik

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

To understand molecular mechanisms of mammary gland involution, several clones were isolated after the primary differential screening of a total 40,000 pfu of involution-specific cDNA library, and further characterized. The partial sequences and Northern analysis revealed that iron metalbolism-related genes and mitochondrial genes were induced during mammary gland involution. The expression of the lactoferrin gene was induced at involution days 1, 2, and 3. The expression of ferritin heavy chain gene was induced at involution days 1, 2, 3 and 4. Cytochrome oxidase subunit I and cytochrome oxidase subunit 2, genes were induced at involution days 4 and 7. The expression of cytochrome b gene was induced at involution day 7. These results imply that iron metabolism and mitochondrial function may be altered during mammary gland involution.

Original languageEnglish
Pages (from-to)164-168
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume224
Issue number1
DOIs
Publication statusPublished - 1996 Jul 5
Externally publishedYes

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Mitochondrial Genes
Human Mammary Glands
Metabolism
Iron
Genes
Electron Transport Complex IV
Apoferritins
Lactoferrin
Cytochromes b
Gene Library
Sequence Analysis
Clone Cells
Gene Expression
Screening

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Iron metabolism-related genes and mitochondrial genes are induced during involution of mouse mammary gland. / Lee, Mijoung; Kim, Hyungha; Jeon, Deahyun; Hwang, Intaek; Choi, Bonghwan; Myung, Kyuho; Kim, Hyunggee; Choi, Yunjaie; Paik, Sanggi; Baik, Myunggi.

In: Biochemical and Biophysical Research Communications, Vol. 224, No. 1, 05.07.1996, p. 164-168.

Research output: Contribution to journalArticle

Lee, Mijoung ; Kim, Hyungha ; Jeon, Deahyun ; Hwang, Intaek ; Choi, Bonghwan ; Myung, Kyuho ; Kim, Hyunggee ; Choi, Yunjaie ; Paik, Sanggi ; Baik, Myunggi. / Iron metabolism-related genes and mitochondrial genes are induced during involution of mouse mammary gland. In: Biochemical and Biophysical Research Communications. 1996 ; Vol. 224, No. 1. pp. 164-168.
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