Is asymptomatic hemorrhagic transformation really innocuous?

J. H. Park, Y. Ko, W. J. Kim, M. S. Jang, M. H. Yang, M. K. Han, C. W. Oh, S. H. Park, Jisung Lee, Juneyoung Lee, H. J. Bae, P. B. Gorelick

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Abstract

Objectives: Asymptomatic hemorrhagic transformation (HT) is not associated with immediate deterioration of patients with acute ischemic stroke. However, it is unclear whether it is clinically innocuous with respect to long-term outcome. The aim of this study was to determine the impact of asymptomatic HT on 3-month outcome. Methods: A consecutive series of 1,618 patients, hospitalized between January 2004 and August 2007 for ischemic stroke within 7 days from symptom onset were identified in a prospective stroke registry database. Those who had no evidence of acute cerebral ischemia on diffusionweighted MRI, who did not undergo T2-weighted gradient echo MRI, whose modified Rankin Scale (mRS) score at 3 months after stroke onset was not available, or who had symptomatic HT were excluded. The odds ratio (OR) of asymptomatic HT was calculated for the full distribution of mRS score and adjusted for variables with p < 0.25 with respect to their associations with asymptomatic HT or functional outcome. Results: Of 1,412 patients eligible for the study, 100 (7.1%) had asymptomatic HT. Patients who experienced asymptomatic HT were more likely to have cardioembolic stroke, to receive thrombolytic therapy, to receive anticoagulation with heparin, and to have a higher initial NIH Stroke Scale score. The crude and adjusted ORs of asymptomatic HT for an increment of mRS score at 3 months were 2.94 (95% confidence interval 2.05-4.24) and 1.90 (1.27-2.82), respectively. Conclusions: Our study shows that the odds of a worse outcome are increased by a factor of 2 in patients with asymptomatic HT compared with those without HT after acute ischemic stroke.

Original languageEnglish
Pages (from-to)421-426
Number of pages6
JournalNeurology
Volume78
Issue number6
DOIs
Publication statusPublished - 2012 Feb 7

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Stroke
Thrombolytic Therapy
Brain Ischemia
Registries
Heparin
Odds Ratio
Databases
Confidence Intervals

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Park, J. H., Ko, Y., Kim, W. J., Jang, M. S., Yang, M. H., Han, M. K., ... Gorelick, P. B. (2012). Is asymptomatic hemorrhagic transformation really innocuous? Neurology, 78(6), 421-426. https://doi.org/10.1212/WNL.0b013e318245d22c

Is asymptomatic hemorrhagic transformation really innocuous? / Park, J. H.; Ko, Y.; Kim, W. J.; Jang, M. S.; Yang, M. H.; Han, M. K.; Oh, C. W.; Park, S. H.; Lee, Jisung; Lee, Juneyoung; Bae, H. J.; Gorelick, P. B.

In: Neurology, Vol. 78, No. 6, 07.02.2012, p. 421-426.

Research output: Contribution to journalArticle

Park, JH, Ko, Y, Kim, WJ, Jang, MS, Yang, MH, Han, MK, Oh, CW, Park, SH, Lee, J, Lee, J, Bae, HJ & Gorelick, PB 2012, 'Is asymptomatic hemorrhagic transformation really innocuous?', Neurology, vol. 78, no. 6, pp. 421-426. https://doi.org/10.1212/WNL.0b013e318245d22c
Park JH, Ko Y, Kim WJ, Jang MS, Yang MH, Han MK et al. Is asymptomatic hemorrhagic transformation really innocuous? Neurology. 2012 Feb 7;78(6):421-426. https://doi.org/10.1212/WNL.0b013e318245d22c
Park, J. H. ; Ko, Y. ; Kim, W. J. ; Jang, M. S. ; Yang, M. H. ; Han, M. K. ; Oh, C. W. ; Park, S. H. ; Lee, Jisung ; Lee, Juneyoung ; Bae, H. J. ; Gorelick, P. B. / Is asymptomatic hemorrhagic transformation really innocuous?. In: Neurology. 2012 ; Vol. 78, No. 6. pp. 421-426.
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AU - Oh, C. W.

AU - Park, S. H.

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AU - Gorelick, P. B.

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