Is preeclampsia itself a risk factor for the development of metabolic syndrome after delivery?

Geum-Joon Cho, Un Suk Jung, Jae Young Sim, Yoo Jin Lee, Na Young Bae, Hye Jin Choi, Jong Heon Park, Hai Joong Kim, Min Jeong Oh

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Objective This study aimed to determine the association between preeclampsia and the postpartum development of metabolic syndrome based on the pre-pregnancy status. Methods Korean women who delivered their first child between January 1, 2011, and December 31, 2012, were enrolled. All subjects underwent a national health screening examination conducted by the National Health Insurance Corporation 1 or 2 years prior to their first delivery and within 2 years after their first delivery. Results Among the 49,065 participants, preeclampsia developed in 3,391 participants (6.9%). The prevalence of metabolic syndrome was higher postpartum in women with preeclampsia than in those without preeclampsia (4.9% vs. 2.7%, respectively, P < 0.001). Through the pre-pregnancy to postpartum period, women with preeclampsia had a greater increase in gestational weight retention, body mass index, waist circumference, systolic blood pressure, and triglyceride levels and a greater decrease in high-density lipoprotein cholesterol levels than women without preeclampsia. Preeclampsia was associated with an increased risk of the postpartum development of metabolic syndrome in women without pre-pregnancy metabolic syndrome (odds ratio, 1.28; 95% confidence interval, 1.05-1.56). However, preeclampsia was not associated with postpartum metabolic syndrome in women with pre-pregnancy metabolic syndrome or 2 components of metabolic syndrome. Conclusion In this study, preeclampsia was associated with the postpartum development of metabolic syndrome in women without pre-pregnancy metabolic syndrome. However, the effects were attenuated by predisposing risk factors in the pre-pregnancy period.

Original languageEnglish
Pages (from-to)233-241
Number of pages9
JournalObstetrics and Gynecology Science
Issue number4
Publication statusPublished - 2019 Jul 1



  • Cardiovascular disease
  • Diabetes mellitus
  • Hypertension
  • Metabolic syndrome
  • Preeclampsia

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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