Is preeclampsia itself a risk factor for the development of metabolic syndrome after delivery?

Geum Joon Cho, Un Suk Jung, Jae Young Sim, Yoo Jin Lee, Na Young Bae, Hye Jin Choi, Jong Heon Park, Hai Joong Kim, Min Jeong Oh

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Objective This study aimed to determine the association between preeclampsia and the postpartum development of metabolic syndrome based on the pre-pregnancy status. Methods Korean women who delivered their first child between January 1, 2011, and December 31, 2012, were enrolled. All subjects underwent a national health screening examination conducted by the National Health Insurance Corporation 1 or 2 years prior to their first delivery and within 2 years after their first delivery. Results Among the 49,065 participants, preeclampsia developed in 3,391 participants (6.9%). The prevalence of metabolic syndrome was higher postpartum in women with preeclampsia than in those without preeclampsia (4.9% vs. 2.7%, respectively, P < 0.001). Through the pre-pregnancy to postpartum period, women with preeclampsia had a greater increase in gestational weight retention, body mass index, waist circumference, systolic blood pressure, and triglyceride levels and a greater decrease in high-density lipoprotein cholesterol levels than women without preeclampsia. Preeclampsia was associated with an increased risk of the postpartum development of metabolic syndrome in women without pre-pregnancy metabolic syndrome (odds ratio, 1.28; 95% confidence interval, 1.05-1.56). However, preeclampsia was not associated with postpartum metabolic syndrome in women with pre-pregnancy metabolic syndrome or 2 components of metabolic syndrome. Conclusion In this study, preeclampsia was associated with the postpartum development of metabolic syndrome in women without pre-pregnancy metabolic syndrome. However, the effects were attenuated by predisposing risk factors in the pre-pregnancy period.

Original languageEnglish
Pages (from-to)233-241
Number of pages9
JournalObstetrics and Gynecology Science
Volume62
Issue number4
DOIs
Publication statusPublished - 2019 Jul 1

Keywords

  • Cardiovascular disease
  • Diabetes mellitus
  • Hypertension
  • Metabolic syndrome
  • Preeclampsia

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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