Is preoperative chronic kidney disease status associated with oncologic outcomes in upper urinary tract urothelial carcinoma? A multicenter propensity score-matched analysis

Ho Song Yu, Jun Eul Hwang, Ho Seok Chung, Yang Hyun Cho, Myung Soo Kim, Eu Chang Hwang, Kyung Jin Oh, Sun Ouck Kim, Seung Il Jung, Taek Won Kang, Dong Deuk Kwon, Kwangsung Park, Soo Bang Ryu, Sung Hoon Jung, Young Hoe Hur, Joon Hwa Noh, Myung Ki Kim, Ill Young Seo, Chul Sung Kim, Sung-Gu KangSeok Ho Kang, Jun Cheon

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Purpose: The aim of this study was to determine the effect of preoperative chronic kidney disease (CKD) on the prognosis of patients with upper urinary tract urothelial carcinoma (UTUC) who had undergone radical nephroureterectomy (RNU). Results: The median follow-up period was 31.1 months (interquartile range: 16.2-55.7 months). Among the study patients, 224 patients in the non-CKD group were selected via propensity score matching. The median recurrence-free, cancerspecific, and overall survival were significantly shorter for patients with preoperative CKD than for non-CKD patients (p = 0.001, p = 0.001, and p = 0.001, respectively). According to multivariable Cox regression analysis, preoperative CKD was related to worse recurrence-free (hazard ratio [HR]: 1.81, 95% confidence interval [CI]: 1.15-2.86, p = 0.011), cancer-specific (HR: 2.44, 95% CI: 1.44-4.14, p = 0.001), and overall survival (HR: 1.66, 95% CI: 1.15-2.40, p = 0.007). Methods: A total of 566 patients who underwent RNU at 6 institutions from 2004 to 2014 were retrospectively reviewed. Of these patients, 342 had an estimated glomerular filtration rate (eGFR) ≥ 60 ml/min/1.73 m2 (non-CKD group) and 224 patients had an eGFR < 60 ml/min/1.73 m2 (CKD group). To adjust for potential baseline confounders, 224 patients in the non-CKD group were selected by propensity matching. Clinicopathological variables and survival rates were compared between the 2 groups. Conclusions: Preoperative CKD appears to be an important independent prognostic factor for oncologic outcomes in patients with UTUC.

Original languageEnglish
Pages (from-to)66540-66549
Number of pages10
JournalOncotarget
Volume8
Issue number39
DOIs
Publication statusPublished - 2017 Jan 1

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Propensity Score
Urinary Tract
Chronic Renal Insufficiency
Carcinoma
Kidney Diseases
Confidence Intervals
Glomerular Filtration Rate
Recurrence
Survival
Survival Rate
Regression Analysis

Keywords

  • Carcinoma
  • Chronic
  • Prognosis
  • Renal insufficiency
  • Transitional cell

ASJC Scopus subject areas

  • Oncology

Cite this

Is preoperative chronic kidney disease status associated with oncologic outcomes in upper urinary tract urothelial carcinoma? A multicenter propensity score-matched analysis. / Yu, Ho Song; Hwang, Jun Eul; Chung, Ho Seok; Cho, Yang Hyun; Kim, Myung Soo; Hwang, Eu Chang; Oh, Kyung Jin; Kim, Sun Ouck; Jung, Seung Il; Kang, Taek Won; Kwon, Dong Deuk; Park, Kwangsung; Ryu, Soo Bang; Jung, Sung Hoon; Hur, Young Hoe; Noh, Joon Hwa; Kim, Myung Ki; Seo, Ill Young; Kim, Chul Sung; Kang, Sung-Gu; Kang, Seok Ho; Cheon, Jun.

In: Oncotarget, Vol. 8, No. 39, 01.01.2017, p. 66540-66549.

Research output: Contribution to journalArticle

Yu, HS, Hwang, JE, Chung, HS, Cho, YH, Kim, MS, Hwang, EC, Oh, KJ, Kim, SO, Jung, SI, Kang, TW, Kwon, DD, Park, K, Ryu, SB, Jung, SH, Hur, YH, Noh, JH, Kim, MK, Seo, IY, Kim, CS, Kang, S-G, Kang, SH & Cheon, J 2017, 'Is preoperative chronic kidney disease status associated with oncologic outcomes in upper urinary tract urothelial carcinoma? A multicenter propensity score-matched analysis', Oncotarget, vol. 8, no. 39, pp. 66540-66549. https://doi.org/10.18632/oncotarget.16239
Yu, Ho Song ; Hwang, Jun Eul ; Chung, Ho Seok ; Cho, Yang Hyun ; Kim, Myung Soo ; Hwang, Eu Chang ; Oh, Kyung Jin ; Kim, Sun Ouck ; Jung, Seung Il ; Kang, Taek Won ; Kwon, Dong Deuk ; Park, Kwangsung ; Ryu, Soo Bang ; Jung, Sung Hoon ; Hur, Young Hoe ; Noh, Joon Hwa ; Kim, Myung Ki ; Seo, Ill Young ; Kim, Chul Sung ; Kang, Sung-Gu ; Kang, Seok Ho ; Cheon, Jun. / Is preoperative chronic kidney disease status associated with oncologic outcomes in upper urinary tract urothelial carcinoma? A multicenter propensity score-matched analysis. In: Oncotarget. 2017 ; Vol. 8, No. 39. pp. 66540-66549.
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abstract = "Purpose: The aim of this study was to determine the effect of preoperative chronic kidney disease (CKD) on the prognosis of patients with upper urinary tract urothelial carcinoma (UTUC) who had undergone radical nephroureterectomy (RNU). Results: The median follow-up period was 31.1 months (interquartile range: 16.2-55.7 months). Among the study patients, 224 patients in the non-CKD group were selected via propensity score matching. The median recurrence-free, cancerspecific, and overall survival were significantly shorter for patients with preoperative CKD than for non-CKD patients (p = 0.001, p = 0.001, and p = 0.001, respectively). According to multivariable Cox regression analysis, preoperative CKD was related to worse recurrence-free (hazard ratio [HR]: 1.81, 95{\%} confidence interval [CI]: 1.15-2.86, p = 0.011), cancer-specific (HR: 2.44, 95{\%} CI: 1.44-4.14, p = 0.001), and overall survival (HR: 1.66, 95{\%} CI: 1.15-2.40, p = 0.007). Methods: A total of 566 patients who underwent RNU at 6 institutions from 2004 to 2014 were retrospectively reviewed. Of these patients, 342 had an estimated glomerular filtration rate (eGFR) ≥ 60 ml/min/1.73 m2 (non-CKD group) and 224 patients had an eGFR < 60 ml/min/1.73 m2 (CKD group). To adjust for potential baseline confounders, 224 patients in the non-CKD group were selected by propensity matching. Clinicopathological variables and survival rates were compared between the 2 groups. Conclusions: Preoperative CKD appears to be an important independent prognostic factor for oncologic outcomes in patients with UTUC.",
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T1 - Is preoperative chronic kidney disease status associated with oncologic outcomes in upper urinary tract urothelial carcinoma? A multicenter propensity score-matched analysis

AU - Yu, Ho Song

AU - Hwang, Jun Eul

AU - Chung, Ho Seok

AU - Cho, Yang Hyun

AU - Kim, Myung Soo

AU - Hwang, Eu Chang

AU - Oh, Kyung Jin

AU - Kim, Sun Ouck

AU - Jung, Seung Il

AU - Kang, Taek Won

AU - Kwon, Dong Deuk

AU - Park, Kwangsung

AU - Ryu, Soo Bang

AU - Jung, Sung Hoon

AU - Hur, Young Hoe

AU - Noh, Joon Hwa

AU - Kim, Myung Ki

AU - Seo, Ill Young

AU - Kim, Chul Sung

AU - Kang, Sung-Gu

AU - Kang, Seok Ho

AU - Cheon, Jun

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Purpose: The aim of this study was to determine the effect of preoperative chronic kidney disease (CKD) on the prognosis of patients with upper urinary tract urothelial carcinoma (UTUC) who had undergone radical nephroureterectomy (RNU). Results: The median follow-up period was 31.1 months (interquartile range: 16.2-55.7 months). Among the study patients, 224 patients in the non-CKD group were selected via propensity score matching. The median recurrence-free, cancerspecific, and overall survival were significantly shorter for patients with preoperative CKD than for non-CKD patients (p = 0.001, p = 0.001, and p = 0.001, respectively). According to multivariable Cox regression analysis, preoperative CKD was related to worse recurrence-free (hazard ratio [HR]: 1.81, 95% confidence interval [CI]: 1.15-2.86, p = 0.011), cancer-specific (HR: 2.44, 95% CI: 1.44-4.14, p = 0.001), and overall survival (HR: 1.66, 95% CI: 1.15-2.40, p = 0.007). Methods: A total of 566 patients who underwent RNU at 6 institutions from 2004 to 2014 were retrospectively reviewed. Of these patients, 342 had an estimated glomerular filtration rate (eGFR) ≥ 60 ml/min/1.73 m2 (non-CKD group) and 224 patients had an eGFR < 60 ml/min/1.73 m2 (CKD group). To adjust for potential baseline confounders, 224 patients in the non-CKD group were selected by propensity matching. Clinicopathological variables and survival rates were compared between the 2 groups. Conclusions: Preoperative CKD appears to be an important independent prognostic factor for oncologic outcomes in patients with UTUC.

AB - Purpose: The aim of this study was to determine the effect of preoperative chronic kidney disease (CKD) on the prognosis of patients with upper urinary tract urothelial carcinoma (UTUC) who had undergone radical nephroureterectomy (RNU). Results: The median follow-up period was 31.1 months (interquartile range: 16.2-55.7 months). Among the study patients, 224 patients in the non-CKD group were selected via propensity score matching. The median recurrence-free, cancerspecific, and overall survival were significantly shorter for patients with preoperative CKD than for non-CKD patients (p = 0.001, p = 0.001, and p = 0.001, respectively). According to multivariable Cox regression analysis, preoperative CKD was related to worse recurrence-free (hazard ratio [HR]: 1.81, 95% confidence interval [CI]: 1.15-2.86, p = 0.011), cancer-specific (HR: 2.44, 95% CI: 1.44-4.14, p = 0.001), and overall survival (HR: 1.66, 95% CI: 1.15-2.40, p = 0.007). Methods: A total of 566 patients who underwent RNU at 6 institutions from 2004 to 2014 were retrospectively reviewed. Of these patients, 342 had an estimated glomerular filtration rate (eGFR) ≥ 60 ml/min/1.73 m2 (non-CKD group) and 224 patients had an eGFR < 60 ml/min/1.73 m2 (CKD group). To adjust for potential baseline confounders, 224 patients in the non-CKD group were selected by propensity matching. Clinicopathological variables and survival rates were compared between the 2 groups. Conclusions: Preoperative CKD appears to be an important independent prognostic factor for oncologic outcomes in patients with UTUC.

KW - Carcinoma

KW - Chronic

KW - Prognosis

KW - Renal insufficiency

KW - Transitional cell

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