Is there protective haplotype of dysbindin gene (DTNBP1) 3 polymorphisms for major depressive disorder

Jung Jin Kim, Laura Mandelli, Chi Un Pae, Diana De Ronchi, Tae Youn Jun, Chul Lee, In Ho Paik, Ashwin A. Patkar, David Steffens, Alessandro Serretti, Changsu Han

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14 Citations (Scopus)

Abstract

Dysbindin gene has been repeatedly associated with psychiatric disorders and schizophrenia in particular. This study aimed to investigate the variants of dysbindin gene in major depressive disorder (MDD). One hundred and eighty eight patients with MDD and 350 controls were investigated for 4 variants within the dysbindin gene (rs3213207 A/G, rs1011313 C/T, rs760761 C/T, and rs2619522 A/C). Haplotype analyses revealed a significant association with MDD (p = 0.0007, protective A-C-T-A and A-C-C-C haplotypes), in particular the effect was due to the rs760761 (C/T) and rs2619522 (A/C) haplotype (p = 0.000026). These results suggest a protective effect of some dysbindin gene haplotypes on the development of MDD. Coupled with previous findings on schizophrenia, our finding suggests that dysbindin gene variants may have a role in the susceptibility to MDD. Adequately powered further studies in different ethnic groups are warranted.

Original languageEnglish
Pages (from-to)375-379
Number of pages5
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume32
Issue number2
DOIs
Publication statusPublished - 2008 Feb 15

Keywords

  • Dysbindin gene
  • Haplotype
  • Major depression

ASJC Scopus subject areas

  • Pharmacology
  • Biological Psychiatry

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    Kim, J. J., Mandelli, L., Pae, C. U., De Ronchi, D., Jun, T. Y., Lee, C., Paik, I. H., Patkar, A. A., Steffens, D., Serretti, A., & Han, C. (2008). Is there protective haplotype of dysbindin gene (DTNBP1) 3 polymorphisms for major depressive disorder. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 32(2), 375-379. https://doi.org/10.1016/j.pnpbp.2007.09.002