Is there relationship between brain atrophy and higher incidence of hip fracture in old age? a preliminary study

Tae Hoon Kim, Seung-Woo Suh, Jin Ho Hwang, Tae Hwan Yoon

Research output: Contribution to journalArticle

Abstract

Purpose: The studies on the correlation between incidence of fall and brain atrophy have been going on to find out the cause of fall and its prevention. The purpose of this study was to explore the relationship between incidence of hip fracture and brain volume, measured by magnetic resonance image. Materials and Methods: A total of 14 subjects with similar conditions (age, height, weight, and past history) were selected for this study. Fracture group (FG) was consisted of 5 subjects with intertrochanteric fracture. Control group (CG) had 9 subjects without intertrochanteric fracture. MRI-based brain volumetry was done in FG and CG with imaging software. Total brain (tBV), absolute cerebellar volumes (aCV) and relative cerebellar volumes (rCV) were compared between two groups. Student t-test was used to statistically analyze the results. Results: In FG, average tBV, aCV and rCV were 1034.676±38.80, 108.648±76.80 and 10.50±0.72 cm3, respectively. In CG, average tBV, aCV and rCV were found to be 1106.459±89.15, 114.899±98.06 and 10.39± 0.53 cm3, respectively, having no statistically significant difference (p>0.05). Conclusion: There was no significant difference between the fracture and control groups. Patients with neurologic disease such as cerebellar ataxia definitely have high incidence of fall that causes fractures and have brain changes as well. However, FG without neurologic disease did not have brain volume change. We consider that high risk of fall with hip fracture might decrease brain function which is not obvious to pickup on MRI.

Original languageEnglish
Pages (from-to)1511-1515
Number of pages5
JournalYonsei Medical Journal
Volume54
Issue number6
DOIs
Publication statusPublished - 2013 Oct 31

Fingerprint

Hip Fractures
Atrophy
Incidence
Brain
Control Groups
Nervous System Diseases
Cerebellar Ataxia
Magnetic Resonance Spectroscopy
Software
Students
Weights and Measures

Keywords

  • Brain atrophy
  • Hip fracture
  • Relationship for high incidence of fall

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Is there relationship between brain atrophy and higher incidence of hip fracture in old age? a preliminary study. / Kim, Tae Hoon; Suh, Seung-Woo; Hwang, Jin Ho; Yoon, Tae Hwan.

In: Yonsei Medical Journal, Vol. 54, No. 6, 31.10.2013, p. 1511-1515.

Research output: Contribution to journalArticle

@article{db7c16d4a22e40c9970602416b2ae582,
title = "Is there relationship between brain atrophy and higher incidence of hip fracture in old age? a preliminary study",
abstract = "Purpose: The studies on the correlation between incidence of fall and brain atrophy have been going on to find out the cause of fall and its prevention. The purpose of this study was to explore the relationship between incidence of hip fracture and brain volume, measured by magnetic resonance image. Materials and Methods: A total of 14 subjects with similar conditions (age, height, weight, and past history) were selected for this study. Fracture group (FG) was consisted of 5 subjects with intertrochanteric fracture. Control group (CG) had 9 subjects without intertrochanteric fracture. MRI-based brain volumetry was done in FG and CG with imaging software. Total brain (tBV), absolute cerebellar volumes (aCV) and relative cerebellar volumes (rCV) were compared between two groups. Student t-test was used to statistically analyze the results. Results: In FG, average tBV, aCV and rCV were 1034.676±38.80, 108.648±76.80 and 10.50±0.72 cm3, respectively. In CG, average tBV, aCV and rCV were found to be 1106.459±89.15, 114.899±98.06 and 10.39± 0.53 cm3, respectively, having no statistically significant difference (p>0.05). Conclusion: There was no significant difference between the fracture and control groups. Patients with neurologic disease such as cerebellar ataxia definitely have high incidence of fall that causes fractures and have brain changes as well. However, FG without neurologic disease did not have brain volume change. We consider that high risk of fall with hip fracture might decrease brain function which is not obvious to pickup on MRI.",
keywords = "Brain atrophy, Hip fracture, Relationship for high incidence of fall",
author = "Kim, {Tae Hoon} and Seung-Woo Suh and Hwang, {Jin Ho} and Yoon, {Tae Hwan}",
year = "2013",
month = "10",
day = "31",
doi = "10.3349/ymj.2013.54.6.1511",
language = "English",
volume = "54",
pages = "1511--1515",
journal = "Yonsei Medical Journal",
issn = "0513-5796",
publisher = "Yonsei University College of Medicine",
number = "6",

}

TY - JOUR

T1 - Is there relationship between brain atrophy and higher incidence of hip fracture in old age? a preliminary study

AU - Kim, Tae Hoon

AU - Suh, Seung-Woo

AU - Hwang, Jin Ho

AU - Yoon, Tae Hwan

PY - 2013/10/31

Y1 - 2013/10/31

N2 - Purpose: The studies on the correlation between incidence of fall and brain atrophy have been going on to find out the cause of fall and its prevention. The purpose of this study was to explore the relationship between incidence of hip fracture and brain volume, measured by magnetic resonance image. Materials and Methods: A total of 14 subjects with similar conditions (age, height, weight, and past history) were selected for this study. Fracture group (FG) was consisted of 5 subjects with intertrochanteric fracture. Control group (CG) had 9 subjects without intertrochanteric fracture. MRI-based brain volumetry was done in FG and CG with imaging software. Total brain (tBV), absolute cerebellar volumes (aCV) and relative cerebellar volumes (rCV) were compared between two groups. Student t-test was used to statistically analyze the results. Results: In FG, average tBV, aCV and rCV were 1034.676±38.80, 108.648±76.80 and 10.50±0.72 cm3, respectively. In CG, average tBV, aCV and rCV were found to be 1106.459±89.15, 114.899±98.06 and 10.39± 0.53 cm3, respectively, having no statistically significant difference (p>0.05). Conclusion: There was no significant difference between the fracture and control groups. Patients with neurologic disease such as cerebellar ataxia definitely have high incidence of fall that causes fractures and have brain changes as well. However, FG without neurologic disease did not have brain volume change. We consider that high risk of fall with hip fracture might decrease brain function which is not obvious to pickup on MRI.

AB - Purpose: The studies on the correlation between incidence of fall and brain atrophy have been going on to find out the cause of fall and its prevention. The purpose of this study was to explore the relationship between incidence of hip fracture and brain volume, measured by magnetic resonance image. Materials and Methods: A total of 14 subjects with similar conditions (age, height, weight, and past history) were selected for this study. Fracture group (FG) was consisted of 5 subjects with intertrochanteric fracture. Control group (CG) had 9 subjects without intertrochanteric fracture. MRI-based brain volumetry was done in FG and CG with imaging software. Total brain (tBV), absolute cerebellar volumes (aCV) and relative cerebellar volumes (rCV) were compared between two groups. Student t-test was used to statistically analyze the results. Results: In FG, average tBV, aCV and rCV were 1034.676±38.80, 108.648±76.80 and 10.50±0.72 cm3, respectively. In CG, average tBV, aCV and rCV were found to be 1106.459±89.15, 114.899±98.06 and 10.39± 0.53 cm3, respectively, having no statistically significant difference (p>0.05). Conclusion: There was no significant difference between the fracture and control groups. Patients with neurologic disease such as cerebellar ataxia definitely have high incidence of fall that causes fractures and have brain changes as well. However, FG without neurologic disease did not have brain volume change. We consider that high risk of fall with hip fracture might decrease brain function which is not obvious to pickup on MRI.

KW - Brain atrophy

KW - Hip fracture

KW - Relationship for high incidence of fall

UR - http://www.scopus.com/inward/record.url?scp=84886528975&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84886528975&partnerID=8YFLogxK

U2 - 10.3349/ymj.2013.54.6.1511

DO - 10.3349/ymj.2013.54.6.1511

M3 - Article

C2 - 24142659

AN - SCOPUS:84886528975

VL - 54

SP - 1511

EP - 1515

JO - Yonsei Medical Journal

JF - Yonsei Medical Journal

SN - 0513-5796

IS - 6

ER -