Abstract
Background: To investigate whether ischemic lesion burden including lesion pattern, number, and volume would vary depending on risk stratification of aortic atheroma (AA). Methods: Acute stroke patients were enrolled if they had (1) acute ischemic lesions on diffusion-weighted imaging within 5 days of symptom onset, (2) cardioembolic stroke established through extensive workup, and (3) only ascending or arch AA detected by transesophageal echocardiography as an embolic source. AA was classified as complex (protruding ≥4 mm into the aortic lumen or any mobile or ulcerative component) or simple (<4 mm). Results: Eighty-one patients (male: 65.4% and age: 66.7 ± 11.0 years) were included in the study. Thirty-four patients (41.9%) had complex atheroma. These patients had a greater number of ischemic lesions (median: 2 lesions [range: 1-42] versus one lesion [range: 1-27], P =.017) and a larger infarct size (9.01 cc [range: 3.58-49.14] versus 4.6 cc [range: 2.3-13.28), P =.056) than the simple atheroma group. Multivariable logistic regression analysis showed that ischemic lesion volume was independently associated with complex atheroma (odds ratio: 1.03, 95% confidence interval: 1.002-2.148, P =.035), while multiple lesions were related (odds ratio: 3.03, 95% confidence interval:.88-10.42, P =.079). Conclusions: Ischemic lesion burden in patients with AA differed according to AA characteristics, suggesting that the morphological features of AA could reflect an embolic potential of AA.
| Original language | English |
|---|---|
| Pages (from-to) | 278-282 |
| Number of pages | 5 |
| Journal | Journal of Stroke and Cerebrovascular Diseases |
| Volume | 23 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2014 Feb 1 |
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Keywords
- aortic arch atherosclerosis
- Ischemic stroke
ASJC Scopus subject areas
- Surgery
- Rehabilitation
- Clinical Neurology
- Cardiology and Cardiovascular Medicine
Cite this
Ischemic lesion burden and characteristics of aortic atheroma. / Jung, Jin-Man; Kwon, Joo Y.; Kim, Hye Jin; Kwon, Sun U.; Song, Jae Kwan; Kim, Jong S.; Kang, Dong Wha.
In: Journal of Stroke and Cerebrovascular Diseases, Vol. 23, No. 2, 01.02.2014, p. 278-282.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Ischemic lesion burden and characteristics of aortic atheroma
AU - Jung, Jin-Man
AU - Kwon, Joo Y.
AU - Kim, Hye Jin
AU - Kwon, Sun U.
AU - Song, Jae Kwan
AU - Kim, Jong S.
AU - Kang, Dong Wha
PY - 2014/2/1
Y1 - 2014/2/1
N2 - Background: To investigate whether ischemic lesion burden including lesion pattern, number, and volume would vary depending on risk stratification of aortic atheroma (AA). Methods: Acute stroke patients were enrolled if they had (1) acute ischemic lesions on diffusion-weighted imaging within 5 days of symptom onset, (2) cardioembolic stroke established through extensive workup, and (3) only ascending or arch AA detected by transesophageal echocardiography as an embolic source. AA was classified as complex (protruding ≥4 mm into the aortic lumen or any mobile or ulcerative component) or simple (<4 mm). Results: Eighty-one patients (male: 65.4% and age: 66.7 ± 11.0 years) were included in the study. Thirty-four patients (41.9%) had complex atheroma. These patients had a greater number of ischemic lesions (median: 2 lesions [range: 1-42] versus one lesion [range: 1-27], P =.017) and a larger infarct size (9.01 cc [range: 3.58-49.14] versus 4.6 cc [range: 2.3-13.28), P =.056) than the simple atheroma group. Multivariable logistic regression analysis showed that ischemic lesion volume was independently associated with complex atheroma (odds ratio: 1.03, 95% confidence interval: 1.002-2.148, P =.035), while multiple lesions were related (odds ratio: 3.03, 95% confidence interval:.88-10.42, P =.079). Conclusions: Ischemic lesion burden in patients with AA differed according to AA characteristics, suggesting that the morphological features of AA could reflect an embolic potential of AA.
AB - Background: To investigate whether ischemic lesion burden including lesion pattern, number, and volume would vary depending on risk stratification of aortic atheroma (AA). Methods: Acute stroke patients were enrolled if they had (1) acute ischemic lesions on diffusion-weighted imaging within 5 days of symptom onset, (2) cardioembolic stroke established through extensive workup, and (3) only ascending or arch AA detected by transesophageal echocardiography as an embolic source. AA was classified as complex (protruding ≥4 mm into the aortic lumen or any mobile or ulcerative component) or simple (<4 mm). Results: Eighty-one patients (male: 65.4% and age: 66.7 ± 11.0 years) were included in the study. Thirty-four patients (41.9%) had complex atheroma. These patients had a greater number of ischemic lesions (median: 2 lesions [range: 1-42] versus one lesion [range: 1-27], P =.017) and a larger infarct size (9.01 cc [range: 3.58-49.14] versus 4.6 cc [range: 2.3-13.28), P =.056) than the simple atheroma group. Multivariable logistic regression analysis showed that ischemic lesion volume was independently associated with complex atheroma (odds ratio: 1.03, 95% confidence interval: 1.002-2.148, P =.035), while multiple lesions were related (odds ratio: 3.03, 95% confidence interval:.88-10.42, P =.079). Conclusions: Ischemic lesion burden in patients with AA differed according to AA characteristics, suggesting that the morphological features of AA could reflect an embolic potential of AA.
KW - aortic arch atherosclerosis
KW - Ischemic stroke
UR - http://www.scopus.com/inward/record.url?scp=84893346455&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84893346455&partnerID=8YFLogxK
U2 - 10.1016/j.jstrokecerebrovasdis.2013.02.013
DO - 10.1016/j.jstrokecerebrovasdis.2013.02.013
M3 - Article
VL - 23
SP - 278
EP - 282
JO - Journal of Stroke and Cerebrovascular Diseases
JF - Journal of Stroke and Cerebrovascular Diseases
SN - 1052-3057
IS - 2
ER -