Ischemic stroke risk during long-term follow up in patients with successful catheter ablation for atrial fibrillation in Korea

Dong Hyeok Kim, Dae In Lee, Jinhee Ahn, Kwang No Lee, Seung Young Roh, Jaemin Shim, Jongil Choi, Young Hoon Kim

Research output: Contribution to journalArticle

Abstract

The interruption of oral anticoagulation therapy (OAC) after CA of atrial fibrillation (AF) is controversial. The purpose of this study was to evaluate the relationship between successful long-term outcomes of catheter resection and SR maintenance and ischemic stroke risk in Korea. We studied 1,548 consecutive patients who were followed up for more than 2 years after CA of AF. We investigated the incidence of ischemic stroke during long-term follow-up. Compared to the AF recurrence group (n = 619), the sinus rhythm (SR) maintenance group (n = 929) had more paroxysmal AF (74.6% versus 44.4%, p<0.001), smaller LA size (39.9 ±5.7mm versus 42.3±6.0mm, p<0.001), and younger age (54.2±10.9 years versus 56.4 ±10.6 years, p<0.001). However, CHA2DS2-VASc scores were not significantly different between the two groups (0.9 vs. 1.1, p = 0.053). The overall incidence of ischemic stroke during the mean follow-up period of 54 months after CA was 0.6%, and was significantly lower in the SR group than the AF recurrence group (0.3% vs. 1.1%, log-rank test p<0.001). However, in sub-analysis in the SR group, the rate of ischemic stroke was significantly increasing in patients with a CHA2DS2-VASc score 4 compared to those with a CHA2DS2-VASc score < 4 (4.3% vs. 0.2%, log-rank test p<0.001). In conclusion, this long-term followup data in patients with AF who underwent successful CA showed that SR maintenance was correlated with a lower rate of ischemic stroke in Korea. However, it was only observed in patients with CHA2DS2-VASc score 3.

Original languageEnglish
Article numbere0201061
Pages (from-to)1DUMMY
JournalPLoS One
Volume13
Issue number7
DOIs
Publication statusPublished - 2018 Jul 1

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Catheter Ablation
Catheters
Korea
Ablation
stroke
catheters
Atrial Fibrillation
Korean Peninsula
sinuses
Stroke
Maintenance
Recurrence
incidence
Incidence
resection
atrial fibrillation
mouth
testing
therapeutics

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Ischemic stroke risk during long-term follow up in patients with successful catheter ablation for atrial fibrillation in Korea. / Kim, Dong Hyeok; Lee, Dae In; Ahn, Jinhee; Lee, Kwang No; Roh, Seung Young; Shim, Jaemin; Choi, Jongil; Kim, Young Hoon.

In: PLoS One, Vol. 13, No. 7, e0201061, 01.07.2018, p. 1DUMMY.

Research output: Contribution to journalArticle

Kim, Dong Hyeok ; Lee, Dae In ; Ahn, Jinhee ; Lee, Kwang No ; Roh, Seung Young ; Shim, Jaemin ; Choi, Jongil ; Kim, Young Hoon. / Ischemic stroke risk during long-term follow up in patients with successful catheter ablation for atrial fibrillation in Korea. In: PLoS One. 2018 ; Vol. 13, No. 7. pp. 1DUMMY.
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abstract = "The interruption of oral anticoagulation therapy (OAC) after CA of atrial fibrillation (AF) is controversial. The purpose of this study was to evaluate the relationship between successful long-term outcomes of catheter resection and SR maintenance and ischemic stroke risk in Korea. We studied 1,548 consecutive patients who were followed up for more than 2 years after CA of AF. We investigated the incidence of ischemic stroke during long-term follow-up. Compared to the AF recurrence group (n = 619), the sinus rhythm (SR) maintenance group (n = 929) had more paroxysmal AF (74.6{\%} versus 44.4{\%}, p<0.001), smaller LA size (39.9 ±5.7mm versus 42.3±6.0mm, p<0.001), and younger age (54.2±10.9 years versus 56.4 ±10.6 years, p<0.001). However, CHA2DS2-VASc scores were not significantly different between the two groups (0.9 vs. 1.1, p = 0.053). The overall incidence of ischemic stroke during the mean follow-up period of 54 months after CA was 0.6{\%}, and was significantly lower in the SR group than the AF recurrence group (0.3{\%} vs. 1.1{\%}, log-rank test p<0.001). However, in sub-analysis in the SR group, the rate of ischemic stroke was significantly increasing in patients with a CHA2DS2-VASc score 4 compared to those with a CHA2DS2-VASc score < 4 (4.3{\%} vs. 0.2{\%}, log-rank test p<0.001). In conclusion, this long-term followup data in patients with AF who underwent successful CA showed that SR maintenance was correlated with a lower rate of ischemic stroke in Korea. However, it was only observed in patients with CHA2DS2-VASc score 3.",
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AU - Roh, Seung Young

AU - Shim, Jaemin

AU - Choi, Jongil

AU - Kim, Young Hoon

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AB - The interruption of oral anticoagulation therapy (OAC) after CA of atrial fibrillation (AF) is controversial. The purpose of this study was to evaluate the relationship between successful long-term outcomes of catheter resection and SR maintenance and ischemic stroke risk in Korea. We studied 1,548 consecutive patients who were followed up for more than 2 years after CA of AF. We investigated the incidence of ischemic stroke during long-term follow-up. Compared to the AF recurrence group (n = 619), the sinus rhythm (SR) maintenance group (n = 929) had more paroxysmal AF (74.6% versus 44.4%, p<0.001), smaller LA size (39.9 ±5.7mm versus 42.3±6.0mm, p<0.001), and younger age (54.2±10.9 years versus 56.4 ±10.6 years, p<0.001). However, CHA2DS2-VASc scores were not significantly different between the two groups (0.9 vs. 1.1, p = 0.053). The overall incidence of ischemic stroke during the mean follow-up period of 54 months after CA was 0.6%, and was significantly lower in the SR group than the AF recurrence group (0.3% vs. 1.1%, log-rank test p<0.001). However, in sub-analysis in the SR group, the rate of ischemic stroke was significantly increasing in patients with a CHA2DS2-VASc score 4 compared to those with a CHA2DS2-VASc score < 4 (4.3% vs. 0.2%, log-rank test p<0.001). In conclusion, this long-term followup data in patients with AF who underwent successful CA showed that SR maintenance was correlated with a lower rate of ischemic stroke in Korea. However, it was only observed in patients with CHA2DS2-VASc score 3.

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