Isoflavones with neuroprotective activities from fruits of Cudrania tricuspidata

Nguyen Tuan Hiep; Jaeyoung Kwon; Dong Woo Kim; Bang Yeon Hwang; Hak Ju Lee; Woongchon Mar; Dongho Lee

doi:10.1016/j.phytochem.2014.10.021

Isoflavones with neuroprotective activities from fruits of Cudrania tricuspidata

Nguyen Tuan Hiep, Jaeyoung Kwon, Dong Woo Kim, Bang Yeon Hwang, Hak Ju Lee, Woongchon Mar, Dongho Lee

Department of Biosystems and Biotechnology

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

Ten isoflavones, cudraisoflavones B-K (1-10), together with 27 known isoflavones, were isolated from the EtOAc soluble extract of fruits of Cudrania tricuspidata. The structures of compounds 1-10 were elucidated on the basis of MS and NMR spectroscopic data, including 2D NMR experiments. Compounds 7-9 and three known (11-13) compounds showed neuroprotective activity against 6-hydroxydopamine induced cell death in human neuroblastoma SH-SY5Y cells, with ^EC50 values of 0.5-9.2 μM.

Original language	English
Pages (from-to)	141-148
Number of pages	8
Journal	Phytochemistry
Volume	111
DOIs	https://doi.org/10.1016/j.phytochem.2014.10.021
Publication status	Published - 2015 Mar

Keywords

6-OHDA
Cudrania tricuspidata
Human neuroblastoma SH-SY5Y
Isoflavones
Moraceae
Neuroprotection
Parkinson's disease

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Plant Science
Horticulture

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.phytochem.2014.10.021

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title = "Isoflavones with neuroprotective activities from fruits of Cudrania tricuspidata",

abstract = "Ten isoflavones, cudraisoflavones B-K (1-10), together with 27 known isoflavones, were isolated from the EtOAc soluble extract of fruits of Cudrania tricuspidata. The structures of compounds 1-10 were elucidated on the basis of MS and NMR spectroscopic data, including 2D NMR experiments. Compounds 7-9 and three known (11-13) compounds showed neuroprotective activity against 6-hydroxydopamine induced cell death in human neuroblastoma SH-SY5Y cells, with EC50 values of 0.5-9.2 μM.",

keywords = "6-OHDA, Cudrania tricuspidata, Human neuroblastoma SH-SY5Y, Isoflavones, Moraceae, Neuroprotection, Parkinson's disease",

author = "Hiep, {Nguyen Tuan} and Jaeyoung Kwon and Kim, {Dong Woo} and Hwang, {Bang Yeon} and Lee, {Hak Ju} and Woongchon Mar and Dongho Lee",

note = "Funding Information: This work was supported by a grant from the Korea University , the Korea Forest Research Institute , and the National Research Foundation of Korea (NRF) grant funded by the Korea government (MEST) (NRF-2013R1A1A2008111). Publisher Copyright: {\textcopyright} 2014 Elsevier Ltd. All rights reserved.",

year = "2015",

month = mar,

doi = "10.1016/j.phytochem.2014.10.021",

language = "English",

volume = "111",

pages = "141--148",

journal = "Phytochemistry",

issn = "0031-9422",

publisher = "Elsevier Limited",

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TY - JOUR

T1 - Isoflavones with neuroprotective activities from fruits of Cudrania tricuspidata

AU - Hiep, Nguyen Tuan

AU - Kwon, Jaeyoung

AU - Kim, Dong Woo

AU - Hwang, Bang Yeon

AU - Lee, Hak Ju

AU - Mar, Woongchon

AU - Lee, Dongho

N1 - Funding Information: This work was supported by a grant from the Korea University , the Korea Forest Research Institute , and the National Research Foundation of Korea (NRF) grant funded by the Korea government (MEST) (NRF-2013R1A1A2008111). Publisher Copyright: © 2014 Elsevier Ltd. All rights reserved.

PY - 2015/3

Y1 - 2015/3

N2 - Ten isoflavones, cudraisoflavones B-K (1-10), together with 27 known isoflavones, were isolated from the EtOAc soluble extract of fruits of Cudrania tricuspidata. The structures of compounds 1-10 were elucidated on the basis of MS and NMR spectroscopic data, including 2D NMR experiments. Compounds 7-9 and three known (11-13) compounds showed neuroprotective activity against 6-hydroxydopamine induced cell death in human neuroblastoma SH-SY5Y cells, with EC50 values of 0.5-9.2 μM.

AB - Ten isoflavones, cudraisoflavones B-K (1-10), together with 27 known isoflavones, were isolated from the EtOAc soluble extract of fruits of Cudrania tricuspidata. The structures of compounds 1-10 were elucidated on the basis of MS and NMR spectroscopic data, including 2D NMR experiments. Compounds 7-9 and three known (11-13) compounds showed neuroprotective activity against 6-hydroxydopamine induced cell death in human neuroblastoma SH-SY5Y cells, with EC50 values of 0.5-9.2 μM.

KW - 6-OHDA

KW - Cudrania tricuspidata

KW - Human neuroblastoma SH-SY5Y

KW - Isoflavones

KW - Moraceae

KW - Neuroprotection

KW - Parkinson's disease

UR - http://www.scopus.com/inward/record.url?scp=84922756688&partnerID=8YFLogxK

U2 - 10.1016/j.phytochem.2014.10.021

DO - 10.1016/j.phytochem.2014.10.021

M3 - Article

C2 - 25487308

AN - SCOPUS:84922756688

SN - 0031-9422

VL - 111

SP - 141

EP - 148

JO - Phytochemistry

JF - Phytochemistry

ER -

Isoflavones with neuroprotective activities from fruits of Cudrania tricuspidata

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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