Isoflurane induces transient anterograde amnesia through suppression of brain-derived neurotrophic factor in hippocampus

Han Jin Cho, Yun Hee Sung, Seung Hwan Lee, Jun Young Chung, Jong Man Kang, Jae Woo Yi

    Research output: Contribution to journalArticlepeer-review

    8 Citations (Scopus)

    Abstract

    Objective: Transient anterograde amnesia is occasionally observed in a number of conditions, including migraine, focal ischemia, venous flow abnormalities, and after general anesthesia. The inhalation anesthetic, isoflurane, is known to induce transient anterograde amnesia. We examined the involvement of brain-derived neurotrophic factor (BDNF) and its receptor tyrosine kinase B (TrkB) in the underlying mechanisms of the isoflurane-induced transient anterograde amnesia. Methods: Adult male Sprague-Dawley rats were divided into three groups: the control group, the 10 minutes after recovery from isoflurane anesthesia group, and the 2 hours after recovery from isoflurane anesthesia group (n=8 in each group). The rats in the isoflurane-exposed groups were anesthetized with 1.2% isoflurane in 75% nitrous oxide and 25% oxygen for 2 hours in a Plexiglas anesthetizing chamber. Short-term memory was determined using the step-down avoidance task. BDNF and TrkB expressions in the hippocampus were evaluated by immunofluorescence staining and western blot analysis. Results: Latency in the step-down avoidance task was decreased 10 minutes after recovery from isoflurane anesthesia, whereas it recovered to the control level 2 hours after isoflurane anesthesia. The expressions of BDNF and TrkB in the hippocampus were decreased immediately after isoflurane anesthesia but were increased 2 hours after isoflurane anesthesia. Conclusion: In this study, isoflurane anesthesia induced transient anterograde amnesia, and the expressions of BDNF and TrkB in the hippocampus might be involved in the underlying mechanisms of this transient anterograde amnesia.

    Original languageEnglish
    Pages (from-to)139-144
    Number of pages6
    JournalJournal of Korean Neurosurgical Society
    Volume53
    Issue number3
    DOIs
    Publication statusPublished - 2013

    Keywords

    • Anterograde amnesia
    • Brain-derived neurotrophic factor
    • Hippocampus
    • Isoflurane
    • Tyrosine kinase b receptor

    ASJC Scopus subject areas

    • Surgery
    • Neuroscience(all)
    • Clinical Neurology

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