Abstract
Objective: Transient anterograde amnesia is occasionally observed in a number of conditions, including migraine, focal ischemia, venous flow abnormalities, and after general anesthesia. The inhalation anesthetic, isoflurane, is known to induce transient anterograde amnesia. We examined the involvement of brain-derived neurotrophic factor (BDNF) and its receptor tyrosine kinase B (TrkB) in the underlying mechanisms of the isoflurane-induced transient anterograde amnesia. Methods: Adult male Sprague-Dawley rats were divided into three groups: the control group, the 10 minutes after recovery from isoflurane anesthesia group, and the 2 hours after recovery from isoflurane anesthesia group (n=8 in each group). The rats in the isoflurane-exposed groups were anesthetized with 1.2% isoflurane in 75% nitrous oxide and 25% oxygen for 2 hours in a Plexiglas anesthetizing chamber. Short-term memory was determined using the step-down avoidance task. BDNF and TrkB expressions in the hippocampus were evaluated by immunofluorescence staining and western blot analysis. Results: Latency in the step-down avoidance task was decreased 10 minutes after recovery from isoflurane anesthesia, whereas it recovered to the control level 2 hours after isoflurane anesthesia. The expressions of BDNF and TrkB in the hippocampus were decreased immediately after isoflurane anesthesia but were increased 2 hours after isoflurane anesthesia. Conclusion: In this study, isoflurane anesthesia induced transient anterograde amnesia, and the expressions of BDNF and TrkB in the hippocampus might be involved in the underlying mechanisms of this transient anterograde amnesia.
| Original language | English |
|---|---|
| Pages (from-to) | 139-144 |
| Number of pages | 6 |
| Journal | Journal of Korean Neurosurgical Society |
| Volume | 53 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2013 May 1 |
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Keywords
- Anterograde amnesia
- Brain-derived neurotrophic factor
- Hippocampus
- Isoflurane
- Tyrosine kinase b receptor
ASJC Scopus subject areas
- Neuroscience(all)
- Surgery
- Clinical Neurology
Cite this
Isoflurane induces transient anterograde amnesia through suppression of brain-derived neurotrophic factor in hippocampus. / Cho, Han Jin; Sung, Yun Hee; Lee, Seung Hwan; Chung, Jun Young; Kang, Jong Man; Yi, Jae Woo.
In: Journal of Korean Neurosurgical Society, Vol. 53, No. 3, 01.05.2013, p. 139-144.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Isoflurane induces transient anterograde amnesia through suppression of brain-derived neurotrophic factor in hippocampus
AU - Cho, Han Jin
AU - Sung, Yun Hee
AU - Lee, Seung Hwan
AU - Chung, Jun Young
AU - Kang, Jong Man
AU - Yi, Jae Woo
PY - 2013/5/1
Y1 - 2013/5/1
N2 - Objective: Transient anterograde amnesia is occasionally observed in a number of conditions, including migraine, focal ischemia, venous flow abnormalities, and after general anesthesia. The inhalation anesthetic, isoflurane, is known to induce transient anterograde amnesia. We examined the involvement of brain-derived neurotrophic factor (BDNF) and its receptor tyrosine kinase B (TrkB) in the underlying mechanisms of the isoflurane-induced transient anterograde amnesia. Methods: Adult male Sprague-Dawley rats were divided into three groups: the control group, the 10 minutes after recovery from isoflurane anesthesia group, and the 2 hours after recovery from isoflurane anesthesia group (n=8 in each group). The rats in the isoflurane-exposed groups were anesthetized with 1.2% isoflurane in 75% nitrous oxide and 25% oxygen for 2 hours in a Plexiglas anesthetizing chamber. Short-term memory was determined using the step-down avoidance task. BDNF and TrkB expressions in the hippocampus were evaluated by immunofluorescence staining and western blot analysis. Results: Latency in the step-down avoidance task was decreased 10 minutes after recovery from isoflurane anesthesia, whereas it recovered to the control level 2 hours after isoflurane anesthesia. The expressions of BDNF and TrkB in the hippocampus were decreased immediately after isoflurane anesthesia but were increased 2 hours after isoflurane anesthesia. Conclusion: In this study, isoflurane anesthesia induced transient anterograde amnesia, and the expressions of BDNF and TrkB in the hippocampus might be involved in the underlying mechanisms of this transient anterograde amnesia.
AB - Objective: Transient anterograde amnesia is occasionally observed in a number of conditions, including migraine, focal ischemia, venous flow abnormalities, and after general anesthesia. The inhalation anesthetic, isoflurane, is known to induce transient anterograde amnesia. We examined the involvement of brain-derived neurotrophic factor (BDNF) and its receptor tyrosine kinase B (TrkB) in the underlying mechanisms of the isoflurane-induced transient anterograde amnesia. Methods: Adult male Sprague-Dawley rats were divided into three groups: the control group, the 10 minutes after recovery from isoflurane anesthesia group, and the 2 hours after recovery from isoflurane anesthesia group (n=8 in each group). The rats in the isoflurane-exposed groups were anesthetized with 1.2% isoflurane in 75% nitrous oxide and 25% oxygen for 2 hours in a Plexiglas anesthetizing chamber. Short-term memory was determined using the step-down avoidance task. BDNF and TrkB expressions in the hippocampus were evaluated by immunofluorescence staining and western blot analysis. Results: Latency in the step-down avoidance task was decreased 10 minutes after recovery from isoflurane anesthesia, whereas it recovered to the control level 2 hours after isoflurane anesthesia. The expressions of BDNF and TrkB in the hippocampus were decreased immediately after isoflurane anesthesia but were increased 2 hours after isoflurane anesthesia. Conclusion: In this study, isoflurane anesthesia induced transient anterograde amnesia, and the expressions of BDNF and TrkB in the hippocampus might be involved in the underlying mechanisms of this transient anterograde amnesia.
KW - Anterograde amnesia
KW - Brain-derived neurotrophic factor
KW - Hippocampus
KW - Isoflurane
KW - Tyrosine kinase b receptor
UR - http://www.scopus.com/inward/record.url?scp=84876752168&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84876752168&partnerID=8YFLogxK
U2 - 10.3340/jkns.2013.53.3.139
DO - 10.3340/jkns.2013.53.3.139
M3 - Article
C2 - 23634262
AN - SCOPUS:84876752168
VL - 53
SP - 139
EP - 144
JO - Journal of Korean Neurosurgical Society
JF - Journal of Korean Neurosurgical Society
SN - 2005-3711
IS - 3
ER -