Isolation and in Vivo and in Vitro Antifungal Activity of Phenylacetic Acid and Sodium Phenylacetate from Streptomyces humidus

Byung Kook Hwang, Song Won Lim, Beom Seok Kim, Jung Yeop Lee, Surk Sik Moon

Research output: Contribution to journalArticle

93 Citations (Scopus)

Abstract

The antifungal substances SH-1 and SH-2 were isolated from Streptomyces humidus strain S5-55 cultures by various purification procedures and identified as phenylacetic acid and sodium phenylacetate, respectively, based on the nuclear magnetic resonance, electron ionization mass spectral, and inductively coupled plasma mass spectral data. SH-1 and SH-2 completely inhibited the growth of Pythium ultimum, Phytophthora capsici, Rhizoctonia solani, Saccharomyces cerevisiae, and Pseudomonas syringae pv. syringae at concentrations from 10 to 50 μg/ml. The two compounds were as effective as the commercial fungicide metalaxyl in inhibiting spore germination and hyphal growth of P. capsici. However, the in vivo control efficacies of the two antifungal compounds against P. capsici infection on pepper plants were similar to those of H3PO3 and fosetyl-Al but less than that of metalaxyl.

Original languageEnglish
Pages (from-to)3739-3745
Number of pages7
JournalApplied and Environmental Microbiology
Volume67
Issue number8
DOIs
Publication statusPublished - 2001 Aug 1

Fingerprint

Streptomyces humidus
phenylacetic acid
Phytophthora capsici
Streptomyces
metalaxyl
sodium
Pythium
Rhizoctonia
Phytophthora
Pseudomonas syringae
acid
fungicide
Growth
Germination
Spores
fosetyl
Pseudomonas syringae pv. syringae
purification
Saccharomyces cerevisiae
nuclear magnetic resonance

ASJC Scopus subject areas

  • Biotechnology
  • Environmental Science(all)
  • Microbiology

Cite this

Isolation and in Vivo and in Vitro Antifungal Activity of Phenylacetic Acid and Sodium Phenylacetate from Streptomyces humidus. / Hwang, Byung Kook; Lim, Song Won; Kim, Beom Seok; Lee, Jung Yeop; Moon, Surk Sik.

In: Applied and Environmental Microbiology, Vol. 67, No. 8, 01.08.2001, p. 3739-3745.

Research output: Contribution to journalArticle

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