Isolation of a sleep-promoting compound from Polygonatum sibiricum rhizome

Kyungae Jo, Hoon Kim, Hyeon Son Choi, Seung Su Lee, Myun Ho Bang, Hyung Joo Suh

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The aim of this study was to identify sleep-promoting substance from Polygonatum sibiricum rhizome extract (PSE) with the regulation of sleep architecture. PSE showed a decrease in sleep latency time and an increase in the sleeping time. In the electroencephalography analysis of rats, PSE (150 mg/kg) showed an increase of non-rapid eye movement by 38% and a decrease of rapid eye movement by 31% compared to the control. This sleep-promoting activity was found to be involved in the GABAA-BDZ receptor. The chemical structure of the pure compound was determined by the 1H and 13C nuclear magnetic resonance spectroscopy and gas chromatography mass spectrometry analysis; active compound was glyceryl-1-monolinoleate. The commercial standard glyceryl-1-monolinoleate showed a similar inhibitory concentration on [3H]-flumazenil binding to GABAA-BDZ receptors with final active fraction of PSE. The results indicate that glyceryl-1-monolinoleate is a major active compound responsible for the PSE-derived sleep promotion.

Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalFood Science and Biotechnology
DOIs
Publication statusAccepted/In press - 2018 Jul 13

Fingerprint

Polygonatum sibiricum
Polygonatum
Rhizome
sleep
rhizomes
Sleep
extracts
GABA-A Receptors
eyes
Flumazenil
receptors
electroencephalography
REM Sleep
Eye Movements
chemical structure
Gas Chromatography-Mass Spectrometry
nuclear magnetic resonance spectroscopy
Electroencephalography
Magnetic Resonance Spectroscopy
rats

Keywords

  • GABA type A-benzodiazepine receptor
  • Glyceryl monolinoleate
  • Insomnia
  • Polygonatum sibiricum
  • Sleep

ASJC Scopus subject areas

  • Biotechnology
  • Food Science
  • Applied Microbiology and Biotechnology

Cite this

Isolation of a sleep-promoting compound from Polygonatum sibiricum rhizome. / Jo, Kyungae; Kim, Hoon; Choi, Hyeon Son; Lee, Seung Su; Bang, Myun Ho; Suh, Hyung Joo.

In: Food Science and Biotechnology, 13.07.2018, p. 1-10.

Research output: Contribution to journalArticle

Jo, Kyungae ; Kim, Hoon ; Choi, Hyeon Son ; Lee, Seung Su ; Bang, Myun Ho ; Suh, Hyung Joo. / Isolation of a sleep-promoting compound from Polygonatum sibiricum rhizome. In: Food Science and Biotechnology. 2018 ; pp. 1-10.
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