Isolation, Structure Elucidation, and Antifungal Activity of a Manumycin-Type Antibiotic from Streptomyces flaveus

Byung Kook Hwang, Jung Yeop Lee, Beom Seok Kim, Surk Sik Moon

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

A manumycin-type antibiotic, SW-B, has been isolated from the solid agar culture of Streptomyces flaveus strain A-11. The structure was determined by mass spectrometry and one- and two-dimensional NMR spectroscopy. SW-B was detected at Rf 0.5 on the TLC plate developed with chloroform-methanol (90:10 v/v). The UV spectrum of SW-B in methanol showed peaks at 208 and 260 nm. The antibiotic SW-B was confirmed to be a derivative of a manumycin-type antibiotic, 2,4,6-trimethyldeca-(2E,4E)-dienamide (C13H23NO, 209.1780). SW-B showed strong antifungal activity against Phytophthora capsici, Magnaporthe grisea, Cladosporium cucumerinum, and Alternaria mali. However, it lacked antimicrobial activity against yeast and bacteria.

Original languageEnglish
Pages (from-to)3653-3657
Number of pages5
JournalJournal of Agricultural and Food Chemistry
Volume44
Issue number11
Publication statusPublished - 1996 Nov 1

Fingerprint

Streptomyces flaveus
Streptomyces
antibiotics
Anti-Bacterial Agents
Methanol
Alternaria mali
methanol
Cladosporium cucumerinum
Magnaporthe
Phytophthora
Mali
Cladosporium
Phytophthora capsici
Alternaria
Magnaporthe grisea
Chloroform
chloroform
Yeast
Nuclear magnetic resonance spectroscopy
Agar

Keywords

  • 2,4,6-Trimethyldeca-(2E,4E)-dienamide
  • Antifungal activity
  • Manumycin
  • Streptomyces flaveus

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Food Science
  • Chemistry (miscellaneous)

Cite this

Isolation, Structure Elucidation, and Antifungal Activity of a Manumycin-Type Antibiotic from Streptomyces flaveus. / Hwang, Byung Kook; Lee, Jung Yeop; Kim, Beom Seok; Moon, Surk Sik.

In: Journal of Agricultural and Food Chemistry, Vol. 44, No. 11, 01.11.1996, p. 3653-3657.

Research output: Contribution to journalArticle

@article{e23f4975a768427580142e3b76ea9df8,
title = "Isolation, Structure Elucidation, and Antifungal Activity of a Manumycin-Type Antibiotic from Streptomyces flaveus",
abstract = "A manumycin-type antibiotic, SW-B, has been isolated from the solid agar culture of Streptomyces flaveus strain A-11. The structure was determined by mass spectrometry and one- and two-dimensional NMR spectroscopy. SW-B was detected at Rf 0.5 on the TLC plate developed with chloroform-methanol (90:10 v/v). The UV spectrum of SW-B in methanol showed peaks at 208 and 260 nm. The antibiotic SW-B was confirmed to be a derivative of a manumycin-type antibiotic, 2,4,6-trimethyldeca-(2E,4E)-dienamide (C13H23NO, 209.1780). SW-B showed strong antifungal activity against Phytophthora capsici, Magnaporthe grisea, Cladosporium cucumerinum, and Alternaria mali. However, it lacked antimicrobial activity against yeast and bacteria.",
keywords = "2,4,6-Trimethyldeca-(2E,4E)-dienamide, Antifungal activity, Manumycin, Streptomyces flaveus",
author = "Hwang, {Byung Kook} and Lee, {Jung Yeop} and Kim, {Beom Seok} and Moon, {Surk Sik}",
year = "1996",
month = "11",
day = "1",
language = "English",
volume = "44",
pages = "3653--3657",
journal = "Journal of Agricultural and Food Chemistry",
issn = "0021-8561",
publisher = "American Chemical Society",
number = "11",

}

TY - JOUR

T1 - Isolation, Structure Elucidation, and Antifungal Activity of a Manumycin-Type Antibiotic from Streptomyces flaveus

AU - Hwang, Byung Kook

AU - Lee, Jung Yeop

AU - Kim, Beom Seok

AU - Moon, Surk Sik

PY - 1996/11/1

Y1 - 1996/11/1

N2 - A manumycin-type antibiotic, SW-B, has been isolated from the solid agar culture of Streptomyces flaveus strain A-11. The structure was determined by mass spectrometry and one- and two-dimensional NMR spectroscopy. SW-B was detected at Rf 0.5 on the TLC plate developed with chloroform-methanol (90:10 v/v). The UV spectrum of SW-B in methanol showed peaks at 208 and 260 nm. The antibiotic SW-B was confirmed to be a derivative of a manumycin-type antibiotic, 2,4,6-trimethyldeca-(2E,4E)-dienamide (C13H23NO, 209.1780). SW-B showed strong antifungal activity against Phytophthora capsici, Magnaporthe grisea, Cladosporium cucumerinum, and Alternaria mali. However, it lacked antimicrobial activity against yeast and bacteria.

AB - A manumycin-type antibiotic, SW-B, has been isolated from the solid agar culture of Streptomyces flaveus strain A-11. The structure was determined by mass spectrometry and one- and two-dimensional NMR spectroscopy. SW-B was detected at Rf 0.5 on the TLC plate developed with chloroform-methanol (90:10 v/v). The UV spectrum of SW-B in methanol showed peaks at 208 and 260 nm. The antibiotic SW-B was confirmed to be a derivative of a manumycin-type antibiotic, 2,4,6-trimethyldeca-(2E,4E)-dienamide (C13H23NO, 209.1780). SW-B showed strong antifungal activity against Phytophthora capsici, Magnaporthe grisea, Cladosporium cucumerinum, and Alternaria mali. However, it lacked antimicrobial activity against yeast and bacteria.

KW - 2,4,6-Trimethyldeca-(2E,4E)-dienamide

KW - Antifungal activity

KW - Manumycin

KW - Streptomyces flaveus

UR - http://www.scopus.com/inward/record.url?scp=0001051240&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0001051240&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0001051240

VL - 44

SP - 3653

EP - 3657

JO - Journal of Agricultural and Food Chemistry

JF - Journal of Agricultural and Food Chemistry

SN - 0021-8561

IS - 11

ER -