Isolation, Structure Elucidation, and Antifungal Activity of a Manumycin-Type Antibiotic from Streptomyces flaveus

Byung Kook Hwang, Jung Yeop Lee, Beom Seok Kim, Surk Sik Moon

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

A manumycin-type antibiotic, SW-B, has been isolated from the solid agar culture of Streptomyces flaveus strain A-11. The structure was determined by mass spectrometry and one- and two-dimensional NMR spectroscopy. SW-B was detected at Rf 0.5 on the TLC plate developed with chloroform-methanol (90:10 v/v). The UV spectrum of SW-B in methanol showed peaks at 208 and 260 nm. The antibiotic SW-B was confirmed to be a derivative of a manumycin-type antibiotic, 2,4,6-trimethyldeca-(2E,4E)-dienamide (C13H23NO, 209.1780). SW-B showed strong antifungal activity against Phytophthora capsici, Magnaporthe grisea, Cladosporium cucumerinum, and Alternaria mali. However, it lacked antimicrobial activity against yeast and bacteria.

Original languageEnglish
Pages (from-to)3653-3657
Number of pages5
JournalJournal of agricultural and food chemistry
Volume44
Issue number11
DOIs
Publication statusPublished - 1996 Nov

Keywords

  • 2,4,6-Trimethyldeca-(2E,4E)-dienamide
  • Antifungal activity
  • Manumycin
  • Streptomyces flaveus

ASJC Scopus subject areas

  • Chemistry(all)
  • Agricultural and Biological Sciences(all)

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