Jatrophane and ingenane-type diterpenoids from Euphorbia kansui inhibit the LPS-induced NO production in RAW 264.7 cells

Jin Woo Lee; Qinghao Jin; Hari Jang; Dongho Lee; Sang Bae Han; Youngsoo Kim; Jin Tae Hong; Mi Kyeong Lee; Bang Yeon Hwang

doi:10.1016/j.bmcl.2016.05.035

Jatrophane and ingenane-type diterpenoids from Euphorbia kansui inhibit the LPS-induced NO production in RAW 264.7 cells

Jin Woo Lee, Qinghao Jin, Hari Jang, Dongho Lee, Sang Bae Han, Youngsoo Kim, Jin Tae Hong, Mi Kyeong Lee, Bang Yeon Hwang

Division of Biotechnology

Research output: Contribution to journal › Article

13 Citations (Scopus)

Abstract

Bioactivity-guided fractionation of the MeOH extract from the roots of Euphorbia kansui resulted in the isolation of two new jatrophane-type diterpenoids, kanesulones A (1) and B (2), together with six known jatrophane-type diterpenoids (3-8) and ten known ingenane-type diterpenoids (9-18). Their chemical structures were elucidated on the basis of spectroscopic data interpretation, especially 1D and 2D NMR such as HMQC, HMBC, COSY and NOESY, and HRESIMS data as well as CD analysis. Compounds 1-8 and 11-18 exhibited the inhibitory effects on LPS-induced nitric oxide production with IC₅₀ values ranging from 0.7 to 46.5μM in RAW 264.7 macrophages.

Original language	English
Journal	Bioorganic and Medicinal Chemistry Letters
DOIs	https://doi.org/10.1016/j.bmcl.2016.05.035
Publication status	Accepted/In press - 2016 Jan 4

Keywords

Diterpenoid
Euphorbia kansui
Euphorbiaceae
Nitric oxide production inhibitor

ASJC Scopus subject areas

Biochemistry
Clinical Biochemistry
Molecular Biology
Molecular Medicine
Organic Chemistry
Drug Discovery
Pharmaceutical Science

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Lee, J. W., Jin, Q., Jang, H., Lee, D., Han, S. B., Kim, Y., Hong, J. T., Lee, M. K., & Hwang, B. Y. (Accepted/In press). Jatrophane and ingenane-type diterpenoids from Euphorbia kansui inhibit the LPS-induced NO production in RAW 264.7 cells. Bioorganic and Medicinal Chemistry Letters. https://doi.org/10.1016/j.bmcl.2016.05.035

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abstract = "Bioactivity-guided fractionation of the MeOH extract from the roots of Euphorbia kansui resulted in the isolation of two new jatrophane-type diterpenoids, kanesulones A (1) and B (2), together with six known jatrophane-type diterpenoids (3-8) and ten known ingenane-type diterpenoids (9-18). Their chemical structures were elucidated on the basis of spectroscopic data interpretation, especially 1D and 2D NMR such as HMQC, HMBC, COSY and NOESY, and HRESIMS data as well as CD analysis. Compounds 1-8 and 11-18 exhibited the inhibitory effects on LPS-induced nitric oxide production with IC50 values ranging from 0.7 to 46.5μM in RAW 264.7 macrophages.",

keywords = "Diterpenoid, Euphorbia kansui, Euphorbiaceae, Nitric oxide production inhibitor",

author = "Lee, {Jin Woo} and Qinghao Jin and Hari Jang and Dongho Lee and Han, {Sang Bae} and Youngsoo Kim and Hong, {Jin Tae} and Lee, {Mi Kyeong} and Hwang, {Bang Yeon}",

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AU - Lee, Jin Woo

AU - Jin, Qinghao

AU - Jang, Hari

AU - Lee, Dongho

AU - Han, Sang Bae

AU - Kim, Youngsoo

AU - Hong, Jin Tae

AU - Lee, Mi Kyeong

AU - Hwang, Bang Yeon

PY - 2016/1/4

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KW - Euphorbiaceae

KW - Nitric oxide production inhibitor

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