Abstract
Bioactivity-guided fractionation of the MeOH extract from the roots of Euphorbia kansui resulted in the isolation of two new jatrophane-type diterpenoids, kanesulones A (1) and B (2), together with six known jatrophane-type diterpenoids (3–8) and ten known ingenane-type diterpenoids (9–18). Their chemical structures were elucidated on the basis of spectroscopic data interpretation, especially 1D and 2D NMR such as HMQC, HMBC, COSY and NOESY, and HRESIMS data as well as CD analysis. Compounds 1–8 and 11–18 exhibited the inhibitory effects on LPS-induced nitric oxide production with IC50values ranging from 0.7 to 46.5 μM in RAW 264.7 macrophages.
Original language | English |
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Pages (from-to) | 3351-3354 |
Number of pages | 4 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 26 |
Issue number | 14 |
DOIs | |
Publication status | Published - 2016 |
Keywords
- Diterpenoid
- Euphorbia kansui
- Euphorbiaceae
- Nitric oxide production inhibitor
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry