Abstract
Bioactivity-guided fractionation of the MeOH extract from the roots of Euphorbia kansui resulted in the isolation of two new jatrophane-type diterpenoids, kanesulones A (1) and B (2), together with six known jatrophane-type diterpenoids (3-8) and ten known ingenane-type diterpenoids (9-18). Their chemical structures were elucidated on the basis of spectroscopic data interpretation, especially 1D and 2D NMR such as HMQC, HMBC, COSY and NOESY, and HRESIMS data as well as CD analysis. Compounds 1-8 and 11-18 exhibited the inhibitory effects on LPS-induced nitric oxide production with IC50 values ranging from 0.7 to 46.5μM in RAW 264.7 macrophages.
| Original language | English |
|---|---|
| Journal | Bioorganic and Medicinal Chemistry Letters |
| DOIs | |
| Publication status | Accepted/In press - 2016 Jan 4 |
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Keywords
- Diterpenoid
- Euphorbia kansui
- Euphorbiaceae
- Nitric oxide production inhibitor
ASJC Scopus subject areas
- Biochemistry
- Clinical Biochemistry
- Molecular Biology
- Molecular Medicine
- Organic Chemistry
- Drug Discovery
- Pharmaceutical Science
Cite this
Jatrophane and ingenane-type diterpenoids from Euphorbia kansui inhibit the LPS-induced NO production in RAW 264.7 cells. / Lee, Jin Woo; Jin, Qinghao; Jang, Hari; Lee, Dongho; Han, Sang Bae; Kim, Youngsoo; Hong, Jin Tae; Lee, Mi Kyeong; Hwang, Bang Yeon.
In: Bioorganic and Medicinal Chemistry Letters, 04.01.2016.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Jatrophane and ingenane-type diterpenoids from Euphorbia kansui inhibit the LPS-induced NO production in RAW 264.7 cells
AU - Lee, Jin Woo
AU - Jin, Qinghao
AU - Jang, Hari
AU - Lee, Dongho
AU - Han, Sang Bae
AU - Kim, Youngsoo
AU - Hong, Jin Tae
AU - Lee, Mi Kyeong
AU - Hwang, Bang Yeon
PY - 2016/1/4
Y1 - 2016/1/4
N2 - Bioactivity-guided fractionation of the MeOH extract from the roots of Euphorbia kansui resulted in the isolation of two new jatrophane-type diterpenoids, kanesulones A (1) and B (2), together with six known jatrophane-type diterpenoids (3-8) and ten known ingenane-type diterpenoids (9-18). Their chemical structures were elucidated on the basis of spectroscopic data interpretation, especially 1D and 2D NMR such as HMQC, HMBC, COSY and NOESY, and HRESIMS data as well as CD analysis. Compounds 1-8 and 11-18 exhibited the inhibitory effects on LPS-induced nitric oxide production with IC50 values ranging from 0.7 to 46.5μM in RAW 264.7 macrophages.
AB - Bioactivity-guided fractionation of the MeOH extract from the roots of Euphorbia kansui resulted in the isolation of two new jatrophane-type diterpenoids, kanesulones A (1) and B (2), together with six known jatrophane-type diterpenoids (3-8) and ten known ingenane-type diterpenoids (9-18). Their chemical structures were elucidated on the basis of spectroscopic data interpretation, especially 1D and 2D NMR such as HMQC, HMBC, COSY and NOESY, and HRESIMS data as well as CD analysis. Compounds 1-8 and 11-18 exhibited the inhibitory effects on LPS-induced nitric oxide production with IC50 values ranging from 0.7 to 46.5μM in RAW 264.7 macrophages.
KW - Diterpenoid
KW - Euphorbia kansui
KW - Euphorbiaceae
KW - Nitric oxide production inhibitor
UR - http://www.scopus.com/inward/record.url?scp=84969961918&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84969961918&partnerID=8YFLogxK
U2 - 10.1016/j.bmcl.2016.05.035
DO - 10.1016/j.bmcl.2016.05.035
M3 - Article
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
SN - 0960-894X
ER -