Jatrophane and ingenane-type diterpenoids from Euphorbia kansui inhibit the LPS-induced NO production in RAW 264.7 cells

Jin Woo Lee; Qinghao Jin; Hari Jang; Dongho Lee; Sang Bae Han; Youngsoo Kim; Jin Tae Hong; Mi Kyeong Lee; Bang Yeon Hwang

doi:10.1016/j.bmcl.2016.05.035

Jatrophane and ingenane-type diterpenoids from Euphorbia kansui inhibit the LPS-induced NO production in RAW 264.7 cells

Jin Woo Lee, Qinghao Jin, Hari Jang, Dongho Lee, Sang Bae Han, Youngsoo Kim, Jin Tae Hong, Mi Kyeong Lee, Bang Yeon Hwang

Department of Biosystems and Biotechnology

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

Bioactivity-guided fractionation of the MeOH extract from the roots of Euphorbia kansui resulted in the isolation of two new jatrophane-type diterpenoids, kanesulones A (1) and B (2), together with six known jatrophane-type diterpenoids (3–8) and ten known ingenane-type diterpenoids (9–18). Their chemical structures were elucidated on the basis of spectroscopic data interpretation, especially 1D and 2D NMR such as HMQC, HMBC, COSY and NOESY, and HRESIMS data as well as CD analysis. Compounds 1–8 and 11–18 exhibited the inhibitory effects on LPS-induced nitric oxide production with IC₅₀values ranging from 0.7 to 46.5 μM in RAW 264.7 macrophages.

Original language	English
Pages (from-to)	3351-3354
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	26
Issue number	14
DOIs	https://doi.org/10.1016/j.bmcl.2016.05.035
Publication status	Published - 2016

Keywords

Diterpenoid
Euphorbia kansui
Euphorbiaceae
Nitric oxide production inhibitor

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2016.05.035

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title = "Jatrophane and ingenane-type diterpenoids from Euphorbia kansui inhibit the LPS-induced NO production in RAW 264.7 cells",

abstract = "Bioactivity-guided fractionation of the MeOH extract from the roots of Euphorbia kansui resulted in the isolation of two new jatrophane-type diterpenoids, kanesulones A (1) and B (2), together with six known jatrophane-type diterpenoids (3–8) and ten known ingenane-type diterpenoids (9–18). Their chemical structures were elucidated on the basis of spectroscopic data interpretation, especially 1D and 2D NMR such as HMQC, HMBC, COSY and NOESY, and HRESIMS data as well as CD analysis. Compounds 1–8 and 11–18 exhibited the inhibitory effects on LPS-induced nitric oxide production with IC50values ranging from 0.7 to 46.5 μM in RAW 264.7 macrophages.",

keywords = "Diterpenoid, Euphorbia kansui, Euphorbiaceae, Nitric oxide production inhibitor",

author = "Lee, {Jin Woo} and Qinghao Jin and Hari Jang and Dongho Lee and Han, {Sang Bae} and Youngsoo Kim and Hong, {Jin Tae} and Lee, {Mi Kyeong} and Hwang, {Bang Yeon}",

note = "Funding Information: This research was supported financially by the Medical Research Center Program (MRC, 2008-0062275) through the National Research Foundation of Korea. The authors acknowledge the Korea Basic Science Institute for the NMR spectroscopic measurements. Funding Information: This research was supported financially by the Medical Research Center Program (MRC, 2008-0062275 ) through the National Research Foundation of Korea . The authors acknowledge the Korea Basic Science Institute for the NMR spectroscopic measurements. Publisher Copyright: {\textcopyright} 2016 Elsevier Ltd",

year = "2016",

doi = "10.1016/j.bmcl.2016.05.035",

language = "English",

volume = "26",

pages = "3351--3354",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Limited",

number = "14",

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TY - JOUR

T1 - Jatrophane and ingenane-type diterpenoids from Euphorbia kansui inhibit the LPS-induced NO production in RAW 264.7 cells

AU - Lee, Jin Woo

AU - Jin, Qinghao

AU - Jang, Hari

AU - Lee, Dongho

AU - Han, Sang Bae

AU - Kim, Youngsoo

AU - Hong, Jin Tae

AU - Lee, Mi Kyeong

AU - Hwang, Bang Yeon

N1 - Funding Information: This research was supported financially by the Medical Research Center Program (MRC, 2008-0062275) through the National Research Foundation of Korea. The authors acknowledge the Korea Basic Science Institute for the NMR spectroscopic measurements. Funding Information: This research was supported financially by the Medical Research Center Program (MRC, 2008-0062275 ) through the National Research Foundation of Korea . The authors acknowledge the Korea Basic Science Institute for the NMR spectroscopic measurements. Publisher Copyright: © 2016 Elsevier Ltd

PY - 2016

Y1 - 2016

N2 - Bioactivity-guided fractionation of the MeOH extract from the roots of Euphorbia kansui resulted in the isolation of two new jatrophane-type diterpenoids, kanesulones A (1) and B (2), together with six known jatrophane-type diterpenoids (3–8) and ten known ingenane-type diterpenoids (9–18). Their chemical structures were elucidated on the basis of spectroscopic data interpretation, especially 1D and 2D NMR such as HMQC, HMBC, COSY and NOESY, and HRESIMS data as well as CD analysis. Compounds 1–8 and 11–18 exhibited the inhibitory effects on LPS-induced nitric oxide production with IC50values ranging from 0.7 to 46.5 μM in RAW 264.7 macrophages.

AB - Bioactivity-guided fractionation of the MeOH extract from the roots of Euphorbia kansui resulted in the isolation of two new jatrophane-type diterpenoids, kanesulones A (1) and B (2), together with six known jatrophane-type diterpenoids (3–8) and ten known ingenane-type diterpenoids (9–18). Their chemical structures were elucidated on the basis of spectroscopic data interpretation, especially 1D and 2D NMR such as HMQC, HMBC, COSY and NOESY, and HRESIMS data as well as CD analysis. Compounds 1–8 and 11–18 exhibited the inhibitory effects on LPS-induced nitric oxide production with IC50values ranging from 0.7 to 46.5 μM in RAW 264.7 macrophages.

KW - Diterpenoid

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KW - Nitric oxide production inhibitor

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JO - Bioorganic and Medicinal Chemistry Letters

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ER -

Jatrophane and ingenane-type diterpenoids from Euphorbia kansui inhibit the LPS-induced NO production in RAW 264.7 cells

Abstract

Keywords

ASJC Scopus subject areas

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