Joint discriminative and representative feature selection for alzheimer’s disease diagnosis

Xiaofeng Zhu, Heung Il Suk, Kim Han Thung, Yingying Zhu, Guorong Wu, Dinggang Shen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)

Abstract

Neuroimaging data have been widely used to derive possible biomarkers for Alzheimer’s Disease (AD) diagnosis. As only certain brain regions are related to AD progression, many feature selection methods have been proposed to identify informative features (i.e., brain regions) to build an accurate prediction model. These methods mostly only focus on the feature-target relationship to select features which are discriminative to the targets (e.g., diagnosis labels). However, since the brain regions are anatomically and functionally connected, there could be useful intrinsic relationships among features. In this paper, by utilizing both the feature-target and feature-feature relationships, we propose a novel sparse regression model to select informative features which are discriminative to the targets and also representative to the features. We argue that the features which are representative (i.e., can be used to represent many other features) are important, as they signify strong “connection” with other ROIs, and could be related to the disease progression. We use our model to select features for both binary and multi-class classification tasks, and the experimental results on the Alzheimer’s Disease Neuroimaging Initiative (ADNI) dataset show that the proposed method outperforms other comparison methods considered in this work.

Original languageEnglish
Title of host publicationMachine Learning in Medical Imaging - 7th International Workshop, MLMI 2016 held in conjunction with MICCAI 2016, Proceedings
EditorsLi Wang, Heung-Il Suk, Yinghuan Shi, Ehsan Adeli, Qian Wang
PublisherSpringer Verlag
Pages77-85
Number of pages9
ISBN (Print)9783319471563
DOIs
Publication statusPublished - 2016
Event7th International Workshop on Machine Learning in Medical Imaging, MLMI 2016 held in conjunction with 19th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2016 - Athens, Greece
Duration: 2016 Oct 172016 Oct 17

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume10019 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Other

Other7th International Workshop on Machine Learning in Medical Imaging, MLMI 2016 held in conjunction with 19th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2016
CountryGreece
CityAthens
Period16/10/1716/10/17

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

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  • Cite this

    Zhu, X., Suk, H. I., Thung, K. H., Zhu, Y., Wu, G., & Shen, D. (2016). Joint discriminative and representative feature selection for alzheimer’s disease diagnosis. In L. Wang, H-I. Suk, Y. Shi, E. Adeli, & Q. Wang (Eds.), Machine Learning in Medical Imaging - 7th International Workshop, MLMI 2016 held in conjunction with MICCAI 2016, Proceedings (pp. 77-85). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 10019 LNCS). Springer Verlag. https://doi.org/10.1007/978-3-319-47157-0_10