Joint optimization of spatial registration and histogram compensation for microscopic images

Sik Kim Dong, Lee Kiryung, Eun Lee Kyung, Sik Han Sung

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

An iterative registration algorithm, the Lucas-Kanade algorithm, is combined with the histogram transformation to jointly optimize the spatial registration and the histogram compensation. Based on a simple regression model, a nonparametric estimator, the empirical conditional mean, is used for the histogram transformation function. The proposed algorithm provides a good performance in registering microscopic images that have different exposure or histogram properties, and can easily adopt other histogram compensation schemes and variations of the Lucas-Kanade algorithms due to its implicit flexibility. Joint registration with a third-order polynomial warp and compensation is conducted for microscopic images that have different magnifications.

Original languageEnglish
Title of host publication28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06
Pages3779-3782
Number of pages4
DOIs
Publication statusPublished - 2006 Dec 1
Event28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06 - New York, NY, United States
Duration: 2006 Aug 302006 Sep 3

Publication series

NameAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
ISSN (Print)0589-1019

Other

Other28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06
CountryUnited States
CityNew York, NY
Period06/8/3006/9/3

Keywords

  • Histogram compensation
  • Lucas-Kanade algorithm
  • Registration

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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  • Cite this

    Dong, S. K., Kiryung, L., Kyung, E. L., & Sung, S. H. (2006). Joint optimization of spatial registration and histogram compensation for microscopic images. In 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06 (pp. 3779-3782). [4030282] (Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings). https://doi.org/10.1109/IEMBS.2006.259863