Abstract
Purpose: There is increasing epidemiological evidence of an association between childhood obesity and atopic dermatitis, but little is known about the underlying mechanism(s). In the present study, we used a rat model of atopic dermatitis to assess whether juvenile obesity, induced by reduction of litter size, aggravated the signs of atopic dermatitis and, if so, whether this aggravation was associated with changes in plasma concentration of adipokines, such as leptin and adiponectin. Methods: Dermatitis was induced by neonatal capsaicin treatment. Body weight, dermatitis score, serum IgE, skin nerve growth factor (NGF), serum leptin and adiponectin, and cytokine mRNA expression in the skin lesion were compared between small (SL, 5 pups) and large litters (LL, 15 pups). Results: The body weight of juvenile rats up to 6 weeks of age was significantly heavier in the SL group, compared with those in the LL group. The SL group showed more robust development of dermatitis, and higher levels of serum IgE and skin NGF than the LL group. Additionally, the SL group demonstrated higher levels of leptin and pro-inflammatory cytokine mRNA but lower levels of adiponectin than the LL group. Conclusions: These results suggest a causal link between a decrease in immunological tolerance, induced by juvenile obesity, and aggravation of atopic dermatitis.
| Original language | English |
|---|---|
| Pages (from-to) | 69-75 |
| Number of pages | 7 |
| Journal | Allergy, Asthma and Immunology Research |
| Volume | 7 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2014 Jan 1 |
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ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Pulmonary and Respiratory Medicine
Cite this
Juvenile obesity aggravates disease severity in a rat model of atopic dermatitis. / Jeong, Keun Yeong; Lee, Jaehee; Li, Chengjin; Han, Taeho; Lee, Sat Byol; Lee, Hyunkyoung; Back, Seung Keun; Na, Heung Sik.
In: Allergy, Asthma and Immunology Research, Vol. 7, No. 1, 01.01.2014, p. 69-75.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Juvenile obesity aggravates disease severity in a rat model of atopic dermatitis
AU - Jeong, Keun Yeong
AU - Lee, Jaehee
AU - Li, Chengjin
AU - Han, Taeho
AU - Lee, Sat Byol
AU - Lee, Hyunkyoung
AU - Back, Seung Keun
AU - Na, Heung Sik
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Purpose: There is increasing epidemiological evidence of an association between childhood obesity and atopic dermatitis, but little is known about the underlying mechanism(s). In the present study, we used a rat model of atopic dermatitis to assess whether juvenile obesity, induced by reduction of litter size, aggravated the signs of atopic dermatitis and, if so, whether this aggravation was associated with changes in plasma concentration of adipokines, such as leptin and adiponectin. Methods: Dermatitis was induced by neonatal capsaicin treatment. Body weight, dermatitis score, serum IgE, skin nerve growth factor (NGF), serum leptin and adiponectin, and cytokine mRNA expression in the skin lesion were compared between small (SL, 5 pups) and large litters (LL, 15 pups). Results: The body weight of juvenile rats up to 6 weeks of age was significantly heavier in the SL group, compared with those in the LL group. The SL group showed more robust development of dermatitis, and higher levels of serum IgE and skin NGF than the LL group. Additionally, the SL group demonstrated higher levels of leptin and pro-inflammatory cytokine mRNA but lower levels of adiponectin than the LL group. Conclusions: These results suggest a causal link between a decrease in immunological tolerance, induced by juvenile obesity, and aggravation of atopic dermatitis.
AB - Purpose: There is increasing epidemiological evidence of an association between childhood obesity and atopic dermatitis, but little is known about the underlying mechanism(s). In the present study, we used a rat model of atopic dermatitis to assess whether juvenile obesity, induced by reduction of litter size, aggravated the signs of atopic dermatitis and, if so, whether this aggravation was associated with changes in plasma concentration of adipokines, such as leptin and adiponectin. Methods: Dermatitis was induced by neonatal capsaicin treatment. Body weight, dermatitis score, serum IgE, skin nerve growth factor (NGF), serum leptin and adiponectin, and cytokine mRNA expression in the skin lesion were compared between small (SL, 5 pups) and large litters (LL, 15 pups). Results: The body weight of juvenile rats up to 6 weeks of age was significantly heavier in the SL group, compared with those in the LL group. The SL group showed more robust development of dermatitis, and higher levels of serum IgE and skin NGF than the LL group. Additionally, the SL group demonstrated higher levels of leptin and pro-inflammatory cytokine mRNA but lower levels of adiponectin than the LL group. Conclusions: These results suggest a causal link between a decrease in immunological tolerance, induced by juvenile obesity, and aggravation of atopic dermatitis.
KW - Adipokine
KW - Adiponectin
KW - Atopic dermatitis
KW - Breast-feeding
KW - Juvenile obesity
KW - Leptin
UR - http://www.scopus.com/inward/record.url?scp=84919399890&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84919399890&partnerID=8YFLogxK
U2 - 10.4168/aair.2015.7.1.69
DO - 10.4168/aair.2015.7.1.69
M3 - Article
AN - SCOPUS:84919399890
VL - 7
SP - 69
EP - 75
JO - Allergy, Asthma and Immunology Research
JF - Allergy, Asthma and Immunology Research
SN - 2092-7355
IS - 1
ER -