K-Map

Connecting kinases with therapeutics for drug repurposing and development

Jihye Kim, Minjae Yoo, Jaewoo Kang, Aik-Choon Tan

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Protein kinases play important roles in regulating signal transduction in eukaryotic cells. Due to evolutionary conserved binding sites in the catalytic domain of the kinases, most inhibitors that target these sites promiscuously inhibit multiple kinases. Quantitative analysis can reveal complex and unexpected interactions between protein kinases and kinase inhibitors, providing opportunities for identifying multi-targeted inhibitors of specific diverse kinases for drug repurposing and development. We have developed K-Map - a novel and user-friendly web-based program that systematically connects a set of query kinases to kinase inhibitors based on quantitative profiles of the kinase inhibitor activities. Users can use K-Map to find kinase inhibitors for a set of query kinases (obtained from high-throughput 'omics' experiments) or to reveal new interactions between kinases and kinase inhibitors for rational drug combination studies.

Original languageEnglish
Article number20
JournalHuman Genomics
Volume7
Issue number1
DOIs
Publication statusPublished - 2013 Jan 1

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Drug Repositioning
Phosphotransferases
Therapeutics
Protein Kinases
Eukaryotic Cells
Drug Combinations

ASJC Scopus subject areas

  • Drug Discovery
  • Genetics
  • Molecular Biology
  • Molecular Medicine

Cite this

K-Map : Connecting kinases with therapeutics for drug repurposing and development. / Kim, Jihye; Yoo, Minjae; Kang, Jaewoo; Tan, Aik-Choon.

In: Human Genomics, Vol. 7, No. 1, 20, 01.01.2013.

Research output: Contribution to journalArticle

Kim, Jihye ; Yoo, Minjae ; Kang, Jaewoo ; Tan, Aik-Choon. / K-Map : Connecting kinases with therapeutics for drug repurposing and development. In: Human Genomics. 2013 ; Vol. 7, No. 1.
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