Kaurane diterpenoids from Isodon excisus inhibit LPS-induced NF-κB activation and NO production in macrophage RAW264.7 cells

Su Hong Seong, Seon A. Lee, Hua Han Xiang, Zi Jin Hui, Hyung Lee Jeong, Dongho Lee, Joon Lee Jung, Tae Hong Jin, Youngsoo Kim, Seup Ro Jai, Yeon Hwang Bang

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

As part of an ongoing search for plant-derived compounds that inhibit the activation of NF-κB, the methanol extract of the aerial parts of Isodon excisus was found to have significant inhibitory effects on the activation of NF-κB in murine macrophage RAW264.7 cells. Bioactivity-guided isolation of the extract yielded five new diterpenoids, excisusin A-E (1-5), along with seven known compounds, inflexarabdonin I (6), inflexarabdonin G (7), inflexin (8), inflexanin A (9), inflexanin B (10), inflexinol (11), and inflexarabdonin A (12). The structures were determined by analysis of the spectroscopic data including 2D NMR. All of the isolates were evaluated for their inhibitory effects on LPS-induced NF-κB activation and nitric oxide production in RAW264.7 cells.

Original languageEnglish
Pages (from-to)632-636
Number of pages5
JournalJournal of Natural Products
Volume70
Issue number4
DOIs
Publication statusPublished - 2007 Apr 1

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Isodon
Kaurane Diterpenes
Diterpenes
Macrophages
diterpenoids
macrophages
Chemical activation
extracts
Phytochemicals
aerial parts
nitric oxide
Methanol
data analysis
Nitric Oxide
methanol
cells
Bioactivity
mice
Nuclear magnetic resonance
Antennas

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Kaurane diterpenoids from Isodon excisus inhibit LPS-induced NF-κB activation and NO production in macrophage RAW264.7 cells. / Seong, Su Hong; Lee, Seon A.; Xiang, Hua Han; Hui, Zi Jin; Jeong, Hyung Lee; Lee, Dongho; Jung, Joon Lee; Jin, Tae Hong; Kim, Youngsoo; Jai, Seup Ro; Bang, Yeon Hwang.

In: Journal of Natural Products, Vol. 70, No. 4, 01.04.2007, p. 632-636.

Research output: Contribution to journalArticle

Seong, SH, Lee, SA, Xiang, HH, Hui, ZJ, Jeong, HL, Lee, D, Jung, JL, Jin, TH, Kim, Y, Jai, SR & Bang, YH 2007, 'Kaurane diterpenoids from Isodon excisus inhibit LPS-induced NF-κB activation and NO production in macrophage RAW264.7 cells', Journal of Natural Products, vol. 70, no. 4, pp. 632-636. https://doi.org/10.1021/np060638+
Seong, Su Hong ; Lee, Seon A. ; Xiang, Hua Han ; Hui, Zi Jin ; Jeong, Hyung Lee ; Lee, Dongho ; Jung, Joon Lee ; Jin, Tae Hong ; Kim, Youngsoo ; Jai, Seup Ro ; Bang, Yeon Hwang. / Kaurane diterpenoids from Isodon excisus inhibit LPS-induced NF-κB activation and NO production in macrophage RAW264.7 cells. In: Journal of Natural Products. 2007 ; Vol. 70, No. 4. pp. 632-636.
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