Kidney transplantation after desensitization in sensitized patients: A Korean National Audit

Kyu Ha Huh, Beom Seok Kim, Jaeseok Yang, Jeongmyung Ahn, Myung Gyu Kim, Jae Berm Park, Jong Man Kim, Byung Ha Chung, Joong Kyung Kim, Jin Min Kong

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10 Citations (Scopus)

Abstract

Introduction The number of end-stage renal disease (ESRD) patients with preformed antibodies waiting for a kidney transplant has been increasing lately. We conducted a nationwide study on the outcomes of kidney transplantation after desensitization in Korea. Methods: Six transplant centers have run desensitization programs. The patients who underwent living donor kidney transplantation after desensitization from 2002 to 2010 were retrospectively analyzed. Results: A total of 86 cases were enrolled. Thirty-five of these were cases of re-transplantation (40.7 %). Indications of desensitization were positive complement-dependent cytotoxicity (CDC) cross-match responses (CDC +, 36.0 %), positive flow-cytometric cross-match responses (FCX?, 54.7 %), and positive donor-specific antibodies (DSA?, 8.1 %). The desensitization protocols used pre-transplant plasmapheresis (95.3 %), intravenous immunoglobulin (62.8 %), and rituximab (67.4 %). Acute rejection occurred in 18 patients (20.9 %), graft failure occurred in 4 patients, and the 3-year graft survival rate was 93.8 %. The presence of DSA increased the acute rejection rate (P = 0.015) and decreased the 1-year post-transplant estimated glomerular filtration rate (P = 0.006). Although rejection-free survival rates did not differ significantly between the CDC+ and FCX? groups, the 1-year estimated glomerular filtration rate was lower in the CDC+ group (P = 0.010). Infectious and significant bleeding complications occurred in 15.5 % and 4.7 % of cases, respectively. Conclusion: Kidney transplantation after desensitization had good graft outcomes and tolerable complications in Korea, and therefore, this therapy can be recommended for sensitized ESRD patients.

Original languageEnglish
Pages (from-to)1549-1557
Number of pages9
JournalInternational Urology and Nephrology
Volume44
Issue number5
DOIs
Publication statusPublished - 2012 Oct
Externally publishedYes

Keywords

  • Immunologic desensitization
  • Kidney transplantation
  • Rejection

ASJC Scopus subject areas

  • Nephrology
  • Urology

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