TY - JOUR
T1 - Kilovoltage radiotherapy for companion animals
T2 - Dosimetric comparison of 300 kV, 450 kV, and 6 MV X-ray beams
AU - Seo, Jaehyeon
AU - Son, Jaeman
AU - Cho, Yeona
AU - Park, Nohwon
AU - Kim, Dong Wook
AU - Kim, Jinsung
AU - Yoon, Myonggeun
N1 - Funding Information:
This work was supported by the National Nuclear R&D Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Education, Science and Technology (NRF-2015M2A2A7A02045273 and NRF-2017M2A2A7081416); and the Ministry of Science and ICT (NRF-2017M2A2A6A01071189), Republic of Korea.
Publisher Copyright:
© 2018 The Korean Society of Veterinary Science.
PY - 2018
Y1 - 2018
N2 - Radiotherapy for the treatment of cancer in companion animals is currently administered by using megavoltage X-ray machines. Because these machines are expensive, most animal hospitals do not perform radiotherapy. This study evaluated the ability of relatively inexpensive kilovoltage X-ray machines to treat companion animals. A simulation study based on a commercial treatment-planning system was performed for tumors of the brain (non-infectious meningoencephalitis), nasal cavity (malignant nasal tumors), forefoot (malignant muscular tumors), and abdomen (malignant intestinal tumors). The results of kilovoltage (300 kV and 450 kV) and megavoltage (6 MV) X-ray beams were compared. Whereas the 300 kV and 6 MV X-ray beams provided optimal radiation dose homogeneity and conformity, respectively, for brain tumors, the 6 MV X-rays provided optimal homogeneity and radiation conformity for nasal cavity, forefoot, and abdominal tumors. Although megavoltage X-ray beams provided better radiation dose distribution in most treated animals, the differences between megavoltage and kilovoltage X-ray beams were relatively small. The similar therapeutic effects of the kilovoltage and 6 MV X-ray beams suggest that kilovoltage X-ray beams may be effective alternatives to megavoltage X-ray beams in treating cancers in companion animals.
AB - Radiotherapy for the treatment of cancer in companion animals is currently administered by using megavoltage X-ray machines. Because these machines are expensive, most animal hospitals do not perform radiotherapy. This study evaluated the ability of relatively inexpensive kilovoltage X-ray machines to treat companion animals. A simulation study based on a commercial treatment-planning system was performed for tumors of the brain (non-infectious meningoencephalitis), nasal cavity (malignant nasal tumors), forefoot (malignant muscular tumors), and abdomen (malignant intestinal tumors). The results of kilovoltage (300 kV and 450 kV) and megavoltage (6 MV) X-ray beams were compared. Whereas the 300 kV and 6 MV X-ray beams provided optimal radiation dose homogeneity and conformity, respectively, for brain tumors, the 6 MV X-rays provided optimal homogeneity and radiation conformity for nasal cavity, forefoot, and abdominal tumors. Although megavoltage X-ray beams provided better radiation dose distribution in most treated animals, the differences between megavoltage and kilovoltage X-ray beams were relatively small. The similar therapeutic effects of the kilovoltage and 6 MV X-ray beams suggest that kilovoltage X-ray beams may be effective alternatives to megavoltage X-ray beams in treating cancers in companion animals.
KW - Companion animals
KW - Radiation therapy
KW - X-ray
UR - http://www.scopus.com/inward/record.url?scp=85050797954&partnerID=8YFLogxK
U2 - 10.4142/jvs.2018.19.4.550
DO - 10.4142/jvs.2018.19.4.550
M3 - Article
C2 - 29649856
AN - SCOPUS:85050797954
SN - 1229-845X
VL - 19
SP - 550
EP - 556
JO - Journal of Veterinary Science
JF - Journal of Veterinary Science
IS - 4
ER -
